Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 7:12 p.m.

Saturday's slate in the MLB includes a matchup between the St. Louis Cardinals and the Cleveland Guardians.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (77-77) vs. Cleveland Guardians (90-65)
• Date: Saturday, September 21, 2024
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: BSGL

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | CLE: (-102)
• Spread: STL: +1.5 (-182) | CLE: -1.5 (+150)
• Total: 8 -- Over: (-118) | Under: (-104)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Miles Mikolas (Cardinals) - 8-11, 5.49 ERA vs Matthew Boyd (Guardians) - 2-1, 2.52 ERA

The Cardinals will give the nod to Miles Mikolas (8-11, 5.49 ERA), who is eyeing win No. 9 on the season, and the Guardians will turn to Matthew Boyd (2-1, 2.52 ERA). When Mikolas starts, his team is 16-14-0 against the spread this season. When Mikolas starts a game and his team is the favorite on the moneyline, they have a record of 2-6. The Guardians have a 5-2-0 ATS record in Boyd's seven starts with a set spread. The Guardians have played while the underdog on the moneyline for three of Boyd's starts this season, and they won every game.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.9%)

Cardinals vs Guardians Moneyline

• The moneyline numbers for Cardinals vs. Guardians reveal St. Louis as the favorite (-116) and Cleveland as the underdog (-102) on the road.

Cardinals vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Cardinals. The Guardians are +150 to cover, while the Cardinals are -182 to cover as a 1.5-run underdog on the runline.

Cardinals vs Guardians Over/Under

• Cardinals versus Guardians, on Sept. 21, has an over/under of 8, with the over being -118 and the under -104.

Bet on St. Louis Cardinals vs. Cleveland Guardians on FanDuel today!

Cardinals vs Guardians Betting Trends

• The Cardinals have been favorites in 68 games this season and have come away with the win 33 times (48.5%) in those contests.
• St. Louis has a record of 30-31 in contests when sportsbooks favor them by -116 or more on the moneyline.
• Contests with the Cardinals have gone over the total set by bookmakers in 68 of 149 chances this season.
• The Cardinals are 71-78-0 against the spread in their 149 games that had a posted line this season.
• The Guardians have won 26 of the 57 games they were the underdog on the moneyline this season (45.6%).
• Cleveland has an 18-27 record (winning 40% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Guardians have combined with opponents to hit the over on the total 69 times this season for a 69-76-8 record against the over/under.
• The Guardians have an 82-71-0 record against the spread this season (covering 53.6% of the time).

Cardinals Player Leaders

• Brendan Donovan leads St. Louis with an OBP of .341, plus a team-best slugging percentage of .412. He's batting .275 on the season.
• Among all qualified hitters in baseball, he ranks 31st in batting average, 39th in on-base percentage, and 79th in slugging.
• Alec Burleson leads St. Louis in total hits (141) this season while batting .269 with 41 extra-base hits. He's slugging .427 with an on-base percentage of .313.
• Among qualifying hitters, he ranks 38th in batting average, 94th in on-base percentage and 67th in slugging percentage.
• Nolan Arenado has collected 149 base hits, an OBP of .322 and a slugging percentage of .393 this season.
• Masyn Winn has been key for St. Louis with 148 hits, an OBP of .313 plus a slugging percentage of .405.

Guardians Player Leaders

• Jose Ramirez has racked up a slugging percentage of .517 and has 164 hits, both team-best figures for the Guardians. He's batting .274 and with an on-base percentage of .332.
• He ranks 33rd in batting average, 50th in on-base percentage and 12th in slugging percentage among all qualified hitters in the big leagues.
• Josh Naylor has 26 doubles, 31 home runs and 56 walks while batting .243. He's slugging .462 with an on-base percentage of .320.
• Including all qualifying hitters, his batting average puts him 97th, his on-base percentage ranks 78th, and he is 38th in slugging.
• Andres Gimenez is batting .253 with 21 doubles, a triple, nine home runs and 26 walks.
• Lane Thomas is batting .241 with 26 doubles, three triples, 14 home runs and 43 walks.

Cardinals vs Guardians Head to Head

• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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