Cardinals vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 4:12 a.m.

The St. Louis Cardinals will take on the Arizona Diamondbacks in MLB action on Thursday.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Diamondbacks Game Info

• St. Louis Cardinals (42-36) vs. Arizona Diamondbacks (41-39)
• Date: Thursday, June 25, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Dbacks.TV

Cardinals vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-132) | ARI: (+112)
• Spread: STL: -1.5 (+160) | ARI: +1.5 (-194)
• Total: 9 -- Over: (-105) | Under: (-115)

Cardinals vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Michael McGreevy (Cardinals) - 3-6, 3.35 ERA vs Zac Gallen (Diamondbacks) - 3-6, 6.10 ERA

This contest's pitching matchup is set, as the Cardinals will send Michael McGreevy (3-6) to the mound, while Zac Gallen (3-6) will answer the bell for the Diamondbacks. McGreevy and his team are 9-6-0 ATS this season when he starts. McGreevy's team has won 50% of his starts when they are favored on the moneyline (2-2). The Diamondbacks have an 8-8-0 record against the spread in Gallen's starts. The Diamondbacks have a 2-7 record in Gallen's nine starts this season when they were the moneyline underdog.

Cardinals vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (60.8%)

Cardinals vs Diamondbacks Moneyline

• Arizona is the underdog, +112 on the moneyline, while St. Louis is a -132 favorite at home.

Cardinals vs Diamondbacks Spread

• The Cardinals are favored by 1.5 runs at home against the Diamondbacks. The Cardinals are +160 to cover the spread, while the Diamondbacks are -194.

Cardinals vs Diamondbacks Over/Under

• The Cardinals-Diamondbacks contest on June 25 has been given an over/under of 9 runs. The over is set at -105 and the under at -115.

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Cardinals vs Diamondbacks Betting Trends

• The Cardinals have won in 14, or 60.9%, of the 23 contests they have been named as odds-on favorites in this year.
• St. Louis has not lost in four games when named as a moneyline favorite of -132 or better.
• Contests with the Cardinals have gone over the total set by bookmakers in 34 of 77 chances this season.
• The Cardinals are 46-31-0 against the spread in their 77 games with a line set by sportsbooks this season.
• The Diamondbacks have been the underdog on the moneyline 41 total times this season. They've finished 16-25 in those games.
• When playing as a moneyline underdog with odds of +112 or longer, Arizona has a 10-14 record (winning 41.7% of its games).
• The Diamondbacks have had an over/under set by oddsmakers 79 times, and have combined with opponents to go over the total in 34 of those games (34-43-2).
• The Diamondbacks have a 44-35-0 record against the spread this season (covering 55.7% of the time).

Cardinals Player Leaders

• Alec Burleson is hitting .288 with 20 doubles, a triple, 13 home runs and 29 walks. He has an on-base percentage of .353 while slugging .490.
• Among qualifying hitters in baseball, he is 21st in batting average, 46th in on-base percentage, and 30th in slugging.
• Burleson will look for his sixth straight game with a hit in this matchup. During his last five outings he is batting .389 with two doubles, a triple, two walks and three RBIs.
• Jordan Walker leads St. Louis with 88 hits and a team-best slugging percentage of .521. He's batting .290 with an on-base percentage of .342.
• Among qualifying hitters, his batting average places him 18th, his on-base percentage 60th, and his slugging percentage 15th.
• Walker has picked up at least one hit in two straight games. During his last five outings he is batting .278 with a walk and an RBI.
• Ivan Herrera has 74 hits this season and a team-best OBP of .404.
• JJ Wetherholt has been key for St. Louis with 76 hits, an OBP of .361 plus a slugging percentage of .414.

Diamondbacks Player Leaders

• Corbin Carroll has accumulated an on-base percentage of .365 and has 80 hits, both team-high numbers for the Diamondbacks. He's batting .279 and slugging .537.
• Including all the qualifying hitters in MLB, his batting average is 38th, his on-base percentage is 35th, and he is ninth in slugging.
• Ketel Marte paces his team with a .461 slugging percentage. He has a batting average of .265 with an on-base percentage of .319.
• His batting average ranks 58th among all qualified players, his on-base percentage ranks 100th, and he is 52nd in slugging.
• Ildemaro Vargas has 11 doubles, two triples, seven home runs and 14 walks while hitting .261.
• Geraldo Perdomo has 10 doubles, three triples, four home runs and 48 walks while hitting .233.

Cardinals vs Diamondbacks Head to Head

• 6/24/2026: 9-4 ARI (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2026: 4-3 ARI (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/22/2026: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/20/2025: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/19/2025: 10-1 ARI (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/18/2025: 7-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/25/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/24/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/23/2025: 4-3 STL (Favorite: Diamondbacks, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/24/2024: 5-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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