Cardinals vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for June 23

Odds updated as of 6:11 a.m.

Monday's slate in the MLB includes a matchup between the St. Louis Cardinals and the Chicago Cubs.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Cubs Game Info

• St. Louis Cardinals (42-36) vs. Chicago Cubs (46-31)
• Date: Monday, June 23, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and MARQ

Cardinals vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | CHC: (-106)
• Spread: STL: +1.5 (-176) | CHC: -1.5 (+146)
• Total: 9 -- Over: (-102) | Under: (-120)

Cardinals vs Cubs Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 4-6, 4.08 ERA vs Ben Brown (Cubs) - 4-5, 5.57 ERA

The Cardinals will give the nod to Matthew Liberatore (4-6) against the Cubs and Ben Brown (4-5). Liberatore and his team have a record of 5-9-0 against the spread when he starts. Liberatore's team is 3-7 this season when he starts and they are the moneyline favorite. The Cubs have a 6-7-0 record against the spread in Brown's starts. The Cubs have a 1-3 record in Brown's four starts this season when they were the underdog on the moneyline.

Cardinals vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (50.8%)

Cardinals vs Cubs Moneyline

• Chicago is the underdog, -106 on the moneyline, while St. Louis is a -110 favorite at home.

Cardinals vs Cubs Spread

• The Cubs are 1.5-run favorites against the spread for this matchup with the Cardinals. The Cubs are +146 to cover, while the Cardinals are -176 to cover as a 1.5-run underdog on the runline.

Cardinals vs Cubs Over/Under

• Cardinals versus Cubs, on June 23, has an over/under of 9, with the over being -102 and the under -120.

Bet on St. Louis Cardinals vs. Chicago Cubs on FanDuel today!

Cardinals vs Cubs Betting Trends

• The Cardinals have been victorious in 19, or 54.3%, of the 35 contests they have been chosen as favorites in this season.
• This season St. Louis has been victorious 19 times in 35 chances when named as a favorite of at least -110 on the moneyline.
• Contests with the Cardinals have gone over the total set by bookmakers in 41 of 78 chances this season.
• The Cardinals are 42-36-0 against the spread in their 78 games that had a posted line this season.
• The Cubs are 9-15 in games they were listed as the moneyline underdog (winning 37.5% of those games).
• Chicago has a record of 9-14 in games it has played as a moneyline underdog with odds of -106 or longer (39.1%).
• The Cubs have played in 75 games with a set over/under, and have combined with opponents to go over the total 40 times (40-31-4).
• The Cubs have gone 38-37-0 ATS this season.

Cardinals Player Leaders

• Nolan Arenado has 11 doubles, a triple, 10 home runs and 23 walks while hitting .247. He has an on-base percentage of .310 and a slugging percentage of .404.
• Among all qualifying hitters in baseball, he is 107th in batting average, 113th in on-base percentage, and 105th in slugging.
• Arenado has recorded a base hit in three straight games. In his last five games he is hitting .300 with two home runs, two walks and three RBIs.
• Brendan Donovan has a slash line of .308/.377/.429 this season and a team-best OPS of .806.
• Among qualifying batters, he ranks 10th in batting average, 21st in on-base percentage and 80th in slugging percentage.
• Lars Nootbaar is batting .229 with a .370 slugging percentage and 31 RBI this year.
• Nootbaar has picked up a hit in four games in a row. During his last five outings he is batting .278 with a double, a home run, four walks and three RBIs.
• Willson Contreras has been key for St. Louis with 66 hits, an OBP of .329 plus a slugging percentage of .409.

Cubs Player Leaders

• Kyle Tucker has a team-high OBP (.395) and slugging percentage (.528). He's batting .285.
• Including all the qualifying hitters in the big leagues, his batting average puts him 31st, his on-base percentage ranks sixth, and he is 14th in slugging.
• Tucker hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .400 with three doubles, two home runs, three walks and three RBIs.
• Pete Crow-Armstrong has 80 hits to pace his team. He has a batting average of .269 while slugging .559 with an on-base percentage of .307.
• Including all qualifying hitters, he ranks 56th in batting average, 121st in on-base percentage and seventh in slugging percentage.
• Seiya Suzuki has 19 doubles, two triples, 20 home runs and 26 walks while hitting .256.
• Nico Hoerner is batting .284 with 17 doubles, a triple and 15 walks.

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