Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 4

Odds updated as of 1:11 p.m.

The Sunday slate in MLB includes a matchup between the Houston Astros and the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs White Sox Game Info

• Houston Astros (17-15) vs. Chicago White Sox (9-24)
• Date: Sunday, May 4, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SCHN

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-172) | CHW: (+144)
• Spread: HOU: -1.5 (-100) | CHW: +1.5 (-120)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 0-0, 0.00 ERA vs Bryse Wilson (White Sox) - 0-1, 5.00 ERA

The probable pitchers are Lance McCullers for the Astros and Bryse Wilson (0-1) for the White Sox. McCullers did not pitch as the moneyline favorite in any games last season. Wilson has started only one game with a set spread, which the White Sox failed to cover. The White Sox were named the moneyline underdog for one Wilson start this season -- they lost.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (61.4%)

Astros vs White Sox Moneyline

• Houston is a -172 favorite on the moneyline, while Chicago is a +144 underdog at home.

Astros vs White Sox Spread

• The White Sox are +1.5 on the run line against the Astros. The White Sox are -120 to cover, and the Astros are -100.

Astros vs White Sox Over/Under

• The Astros-White Sox game on May 4 has been given an over/under of 8.5 runs. The over is set at -102 and the under at -120.

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Astros vs White Sox Betting Trends

• The Astros have won in 12, or 52.2%, of the 23 contests they have been named as odds-on favorites in this year.
• Houston has been listed as a favorite of -172 or more on two occasions this season and split those games.
• The Astros and their opponents have gone over in 14 of their 32 games with a total set by sportsbooks this season.
• The Astros are 18-14-0 against the spread in their 32 games that had a posted line this season.
• The White Sox have won nine of the 33 games they were the moneyline underdog this season (27.3%).
• Chicago has a record of 5-16 when it has played as a moneyline underdog with odds of +144 or longer (23.8%).
• The White Sox have combined with opponents to hit the over on the total 16 times this season for a 16-15-2 record against the over/under.
• The White Sox have collected a 17-16-0 record ATS this season (covering 51.5% of the time).

Astros Player Leaders

• Jeremy Pena leads Houston with 34 hits and a team-best slugging percentage of .425. He's batting .283 with an on-base percentage of .351.
• Among qualifying hitters in MLB, his batting average ranks 34th, his on-base percentage ranks 53rd, and he is 72nd in slugging.
• Pena has recorded a base hit in seven games in a row. In his last 10 games he is batting .390 with two doubles, a home run, two walks and five RBI.
• Isaac Paredes has 30 hits this season and a team-best OBP of .353. He's batting .250 and slugging .392.
• His batting average is 82nd among qualified players, his on-base percentage 50th, and his slugging percentage 103rd.
• Paredes brings a five-game streak with at least one hit into this one. During his last five outings he is batting .278 with a triple, four walks and an RBI.
• Jose Altuve has hit four homers with a team-high .386 SLG this season.
• Altuve has recorded a hit in three games in a row. In his last five games he is hitting .238 with a double, a home run, three walks and five RBI.
• Jake Meyers has been key for Houston with 26 hits, an OBP of .337 plus a slugging percentage of .443.
• Meyers brings a four-game hitting streak into this matchup. In his last five games he is batting .444 with a double, a triple, two home runs, a walk and eight RBI.

White Sox Player Leaders

• Luis Robert is hitting .182 with three doubles, five home runs and 19 walks. He's slugging .345 with an on-base percentage of .300.
• He ranks 154th in batting average, 114th in on-base percentage and 124th in slugging percentage among all qualified hitters in the majors.
• Miguel Vargas paces his team with a .315 OBP. He has a batting average of .219 while slugging .325.
• Including all qualifying hitters, his batting average puts him 123rd, his on-base percentage ranks 88th, and he is 140th in slugging.
• Andrew Benintendi is hitting .232 with five home runs and eight walks.
• Brooks Baldwin's 22 hits lead his team.

Astros vs White Sox Head to Head

• 5/3/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/2/2025: 7-3 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/18/2024: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 8/17/2024: 6-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 8/16/2024: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/20/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 6/19/2024: 4-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/18/2024: 2-0 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/14/2023: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/13/2023: 3-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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