Angels vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 11:12 p.m.

The Sunday slate in MLB includes a matchup between the Los Angeles Angels and the Houston Astros.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Angels vs Astros Game Info

• Los Angeles Angels (36-39) vs. Houston Astros (44-32)
• Date: Sunday, June 22, 2025
• Time: 4:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Angels vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAA: (-116) | HOU: (-102)
• Spread: LAA: +1.5 (-200) | HOU: -1.5 (+164)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Angels vs Astros Probable Starting Pitchers

Probable Pitchers: Kyle Hendricks (Angels) - 5-6, 4.79 ERA vs Ryan Gusto (Astros) - 4-3, 4.31 ERA

The probable pitchers are Kyle Hendricks (5-6) for the Angels and Ryan Gusto (4-3) for the Astros. Hendricks and his team are 7-7-0 ATS this season when he starts. Hendricks' team is 1-1 this season when he starts and they're favored on the moneyline. The Astros have a 4-6-0 record against the spread in Gusto's starts. The Astros have always been the moneyline underdog when Gusto starts this season.

Angels vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (62.7%)

Angels vs Astros Moneyline

• Looking at the moneyline for Angels-Astros, Los Angeles is the favorite at -116, and Houston is -102 playing on the road.

Angels vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Angels. The Astros are +164 to cover, while the Angels are -200 to cover as a 1.5-run underdog on the runline.

Angels vs Astros Over/Under

• Angels versus Astros, on June 22, has an over/under of 8.5, with the over being -102 and the under -120.

Bet on Los Angeles Angels vs. Houston Astros on FanDuel today!

Angels vs Astros Betting Trends

• The Angels have been favorites in 14 games this season and have come away with the win eight times (57.1%) in those contests.
• This season Los Angeles has been victorious eight times in 13 chances when named as a favorite of at least -116 on the moneyline.
• The Angels and their opponents have hit the over in 37 of their 74 games with a total set by oddsmakers this season.
• The Angels are 38-36-0 against the spread in their 74 games with a line set by sportsbooks this season.
• The Astros have gone 13-9 in games they were listed as the moneyline underdog (winning 59.1% of those games).
• Houston is 8-8 (winning 50% of its games) when playing as a moneyline underdog of -102 or longer.
• The Astros have played in 75 games with a set over/under, and have combined with opponents to go over the total 29 times (29-44-2).
• The Astros have covered 53.3% of their games this season, going 40-35-0 against the spread.

Angels Player Leaders

• Nolan Schanuel leads Los Angeles with an OBP of .363, plus a team-best slugging percentage of .390. He's batting .273 on the season.
• Among all qualifying batters in baseball, his batting average ranks 44th, his on-base percentage ranks 29th, and he is 115th in slugging.
• Taylor Ward has 13 doubles, a triple, 19 home runs and 24 walks. He's batting .209 and slugging .465 with an on-base percentage of .269.
• Among qualified batters, his batting average places him 152nd, his on-base percentage 156th, and his slugging percentage 43rd.
• Ward takes a two-game streak with at least one hit into this matchup. In his last five games he is hitting .150 with a home run, two walks and three RBIs.
• Zach Neto has 61 hits this season and has a slash line of .263/.306/.457.
• Jo Adell has 47 hits, which is tops among Los Angeles hitters this season, while batting .222 with 23 extra-base hits.
• Adell has hit safely in three straight games. During his last five outings he is hitting .167 with three home runs, two walks and four RBIs.

Astros Player Leaders

• Jeremy Pena has accumulated a team-high OBP (.383) and slugging percentage (.486), and paces the Astros in hits (97, while batting .328).
• Including all the qualifying hitters in MLB, his batting average puts him fourth, his on-base percentage is 13th, and he is 28th in slugging.
• Pena brings a three-game hitting streak into this game. In his last five games he is hitting .364 with a home run, two walks and four RBIs.
• Isaac Paredes has 10 doubles, a triple, 16 home runs and 41 walks while hitting .253. He's slugging .476 with an on-base percentage of .360.
• He is currently 87th in batting average, 31st in on-base percentage and 38th in slugging percentage among all qualified hitters.
• Jose Altuve has 10 doubles, 12 home runs and 21 walks while hitting .269.
• Jake Meyers is hitting .307 with 13 doubles, a triple, three home runs and 23 walks.

Angels vs Astros Head to Head

• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/22/2024: 9-8 LAA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 9/21/2024: 10-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 9/20/2024: 9-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 9/19/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/15/2024: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/14/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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