Angels vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 3:11 p.m.

The Sunday slate in MLB includes a matchup between the Los Angeles Angels and the Houston Astros.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Angels vs Astros Game Info

• Los Angeles Angels (37-39) vs. Houston Astros (44-33)
• Date: Sunday, June 22, 2025
• Time: 4:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Angels vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAA: (-116) | HOU: (-102)
• Spread: LAA: +1.5 (-200) | HOU: -1.5 (+164)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Angels vs Astros Probable Starting Pitchers

Probable Pitchers: Kyle Hendricks (Angels) - 5-6, 4.79 ERA vs Ryan Gusto (Astros) - 4-3, 4.31 ERA

The probable starters are Kyle Hendricks (5-6) for the Angels and Ryan Gusto (4-3) for the Astros. When Hendricks starts, his team is 7-7-0 against the spread this season. Hendricks' team is 1-1 this season when he starts and they're favored on the moneyline. The Astros have a 4-6-0 ATS record in Gusto's 10 starts with a set spread. The Astros have yet to be named a moneyline underdog when Gusto starts this season.

Angels vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (62%)

Angels vs Astros Moneyline

• Houston is a -102 underdog on the moneyline, while Los Angeles is a -116 favorite at home.

Angels vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Angels. The Astros are +164 to cover, while the Angels are -200 to cover as a 1.5-run underdog on the runline.

Angels vs Astros Over/Under

• A combined run total of 8.5 has been set for Angels-Astros on June 22, with the over at -102 and the under at -120.

Bet on Los Angeles Angels vs. Houston Astros on FanDuel today!

Angels vs Astros Betting Trends

• The Angels have been favorites in 15 games this season and have come away with the win nine times (60%) in those contests.
• This season Los Angeles has come away with a win nine times in 14 chances when named as a favorite of at least -116 on the moneyline.
• The Angels and their opponents have gone over in 38 of their 75 games with a total set by sportsbooks this season.
• The Angels have an against the spread record of 39-36-0 in 75 games with a line this season.
• The Astros have gone 13-10 in games they were the underdog on the moneyline (winning 56.5% of those games).
• When playing as a moneyline underdog with odds of -102 or longer, Houston has a record of 8-8 (50%).
• The Astros have combined with opponents to hit the over on the total 30 times this season for a 30-44-2 record against the over/under.
• The Astros have put together a 40-36-0 record ATS this season (covering 52.6% of the time).

Angels Player Leaders

• Nolan Schanuel leads Los Angeles OPS (.761) this season. He has a .277 batting average, an on-base percentage of .368, and a slugging percentage of .393.
• Among qualifying batters in the majors, he ranks 42nd in batting average, 26th in on-base percentage, and 115th in slugging.
• Taylor Ward has 14 doubles, a triple, 19 home runs and 25 walks. He's batting .210 and slugging .465 with an on-base percentage of .271.
• He is 154th in batting average, 154th in on-base percentage and 45th in slugging among qualified hitters.
• Ward enters this game looking to extend his three-game hit streak. During his last five outings he is hitting .200 with a double, a home run, two walks and five RBIs.
• Zach Neto is batting .267 with a .466 slugging percentage and 26 RBI this year.
• Jo Adell leads Los Angeles with 48 hits, batting .223 this season with 23 extra-base hits.
• Adell heads into this game on a four-game hitting streak. During his last five outings he is hitting .235 with three home runs, three walks and four RBIs.

Astros Player Leaders

• Jeremy Pena has accumulated an on-base percentage of .380, a slugging percentage of .482, and has 97 hits, all club-bests for the Astros (while batting .324).
• Including all the qualified hitters in the big leagues, his batting average is sixth, his on-base percentage ranks 18th, and he is 32nd in slugging.
• Isaac Paredes is batting .254 with 10 doubles, a triple, 16 home runs and 41 walks. He's slugging .474 with an on-base percentage of .359.
• Including all qualified hitters, he ranks 88th in batting average, 33rd in on-base percentage and 40th in slugging percentage.
• Jose Altuve is batting .269 with 10 doubles, 12 home runs and 24 walks.
• Jake Meyers is hitting .307 with 13 doubles, a triple, three home runs and 23 walks.

Angels vs Astros Head to Head

• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/22/2024: 9-8 LAA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 9/21/2024: 10-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 9/20/2024: 9-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 9/19/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/15/2024: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -200, Underdog Moneyline: +168)

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