Giants vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 3:11 p.m.

The San Francisco Giants will face the Boston Red Sox in MLB action on Sunday.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Red Sox Game Info

• San Francisco Giants (43-34) vs. Boston Red Sox (40-38)
• Date: Sunday, June 22, 2025
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and NESN

Giants vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-164) | BOS: (+138)
• Spread: SF: -1.5 (+134) | BOS: +1.5 (-162)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Giants vs Red Sox Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Giants) - 8-2, 2.68 ERA vs Lucas Giolito (Red Sox) - 3-1, 4.73 ERA

The Giants will give the ball to Robbie Ray (8-2, 2.68 ERA), who is eyeing win No. 9 on the season, and the Red Sox will counter with Lucas Giolito (3-1, 4.73 ERA). Ray and his team have a record of 10-5-0 against the spread when he starts. When Ray starts a game and his team is the favorite on the moneyline, they have a record of 8-3. The Red Sox have a 6-3-0 record against the spread in Giolito's starts. The Red Sox have a 3-1 record in Giolito's four starts this season when they were the moneyline underdog.

Giants vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (55.1%)

Giants vs Red Sox Moneyline

• San Francisco is the favorite, -164 on the moneyline, while Boston is a +138 underdog on the road.

Giants vs Red Sox Spread

• The Giants are hosting the Red Sox and are favored by 1.5 runs (+134 to cover) on the runline. Boston is -162 to cover.

Giants vs Red Sox Over/Under

• The over/under for the Giants versus Red Sox game on June 22 has been set at 7.5, with -100 odds on the over and -122 odds on the under.

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Giants vs Red Sox Betting Trends

• The Giants have come away with 29 wins in the 50 contests they have been listed as the favorites in this season.
• This season San Francisco has been victorious eight times in 12 chances when named as a favorite of at least -164 on the moneyline.
• The Giants and their opponents have hit the over in 34 of their 77 games with a total set by oddsmakers this season.
• The Giants have posted a record of 34-43-0 against the spread this season.
• The Red Sox have won 48.1% of the games this season they were the moneyline underdog (13-14).
• Boston has gone 5-3 when playing as a moneyline underdog with odds of +138 or longer (62.5%).
• The Red Sox have played in 78 games with a set over/under, and have combined with opponents to go over the total 35 times (35-41-2).
• The Red Sox have put together a 42-36-0 record against the spread this season (covering 53.8% of the time).

Giants Player Leaders

• Rafael Devers leads San Francisco with 78 hits and an OBP of .393 this season. He has a .267 batting average and a slugging percentage of .497.
• He is 56th in batting average, seventh in on-base percentage, and 24th in slugging among qualifying hitters in the majors.
• Jung Hoo Lee has 17 doubles, five triples, six home runs and 26 walks. He's batting .255 and slugging .415 with an on-base percentage of .319.
• He is 82nd in batting average, 101st in on-base percentage and 95th in slugging among qualified hitters.
• Heliot Ramos has an OPS of .830, fueled by an OBP of .360 and a team-best slugging percentage of .470 this season.
• Ramos has picked up a hit in two games in a row. During his last five outings he is batting .222 with two home runs, two walks and three RBIs.
• Wilmer Flores has been key for San Francisco with 67 hits, an OBP of .325 plus a slugging percentage of .407.
• Flores heads into this game on a two-game hitting streak. During his last five outings he is batting .154 with a double, a walk and three RBIs.

Red Sox Player Leaders

• Jarren Duran has accumulated a slugging percentage of .407, a team-high for the Red Sox. He's batting .257 with an on-base percentage of .310.
• Including all the qualified hitters in the big leagues, his batting average is 76th, his on-base percentage is 112th, and he is 101st in slugging.
• Wilyer Abreu has 55 hits with a .326 OBP to pace his team in both. He has a batting average of .255 while slugging .477.
• He is currently 82nd in batting average, 85th in on-base percentage and 36th in slugging percentage among all qualifying hitters.
• Ceddanne Rafaela has 12 doubles, two triples, seven home runs and 14 walks while batting .251.
• Carlos Narvaez has 15 doubles, six home runs and 26 walks while batting .270.

Giants vs Red Sox Head to Head

• 6/21/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/20/2025: 7-5 BOS (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/2/2024: 3-1 SF (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/1/2024: 6-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/30/2024: 4-0 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/30/2023: 4-3 SF (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/29/2023: 3-2 SF (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/28/2023: 3-2 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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