Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 6:11 a.m.

The MLB slate on Sunday includes the Cleveland Guardians facing the Athletics.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs Athletics Game Info

• Cleveland Guardians (38-37) vs. Athletics (32-47)
• Date: Sunday, June 22, 2025
• Time: 4:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and CLEG

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | OAK: (+114)
• Spread: CLE: -1.5 (+118) | OAK: +1.5 (-142)
• Total: 9.5 -- Over: (+102) | Under: (-124)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 2-3, 4.15 ERA vs JP Sears (Athletics) - 5-6, 5.45 ERA

The Guardians will give the nod to Slade Cecconi (2-3) against the Athletics and JP Sears (5-6). When Cecconi starts, his team is 4-2-0 against the spread this season. Cecconi's team is 1-1 this season when he starts and they're favored on the moneyline. The Athletics have gone 8-7-0 ATS in Sears' 15 starts with a set spread. The Athletics have been the underdog on the moneyline in nine of Sears' starts this season, and they went 2-7 in those matchups.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (53.6%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -134 favorite, while the Athletics are a +114 underdog at home.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +118 to cover, while the Athletics are -142 to cover.

Guardians vs Athletics Over/Under

• A combined run total of 9.5 has been set for Guardians-Athletics on June 22, with the over at +102 and the under at -124.

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Guardians vs Athletics Betting Trends

• The Guardians have been victorious in 15, or 60%, of the 25 contests they have been chosen as favorites in this season.
• This season, the Guardians have come away with a win eight times in 11 chances when named as a favorite of at least -134 or better on the moneyline.
• The Guardians and their opponents have hit the over in 31 of their 73 games with a total this season.
• The Guardians have posted a record of 37-36-0 against the spread this season.
• The Athletics have been the underdog on the moneyline 59 total times this season. They've finished 21-38 in those games.
• When they have played as a moneyline underdog with odds of +114 or longer, the Athletics have a record of 11-31 (26.2%).
• The Athletics have played in 79 games with an over/under set, and have combined with their opponents to go over the total 43 times (43-33-3).
• The Athletics have a 38-41-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 89 hits and an OBP of .385, plus a team-best slugging percentage of .531. He's batting .324.
• Among the qualifying hitters in the majors, his batting average ranks sixth, his on-base percentage ranks 13th, and he is 11th in slugging.
• Ramirez hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .316 with a double, two walks and two RBIs.
• Steven Kwan has 17 doubles, six home runs and 25 walks. He's batting .305 and slugging .430 with an on-base percentage of .366.
• Among qualified hitters, his batting average places him 13th, his on-base percentage 30th, and his slugging percentage 79th.
• Kwan enters this game looking to extend his three-game hit streak. In his last five games he is batting .368 with three doubles, two walks and an RBI.
• Carlos Santana is batting .236 with a .356 slugging percentage and 36 RBI this year.
• Kyle Manzardo has 11 home runs, 31 RBI and a batting average of .217 this season.

Athletics Player Leaders

• Jacob Wilson has put up a team-high OBP (.392) and slugging percentage (.498), and paces the Athletics in hits (102, while batting .353).
• Including all the qualifying players in MLB, he is second in batting average, ninth in on-base percentage and 22nd in slugging percentage.
• Brent Rooker has 16 doubles, two triples, 15 home runs and 35 walks while batting .272. He's slugging .482 with an on-base percentage of .350.
• Including all qualified hitters, he ranks 46th in batting average, 50th in on-base percentage and 32nd in slugging percentage.
• Tyler Soderstrom is batting .249 with 11 doubles, a triple, 14 home runs and 33 walks.
• Lawrence Butler is batting .261 with 23 doubles, a triple, 11 home runs and 27 walks.

Guardians vs Athletics Head to Head

• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/20/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/19/2024: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2024: 4-3 OAK (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/30/2024: 12-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/29/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/28/2024: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/22/2023: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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