Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 3:11 p.m.

The Sunday schedule in MLB includes a matchup between the Cleveland Guardians and the Athletics.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Athletics Game Info

• Cleveland Guardians (38-37) vs. Athletics (32-47)
• Date: Sunday, June 22, 2025
• Time: 4:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and CLEG

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | OAK: (+114)
• Spread: CLE: -1.5 (+118) | OAK: +1.5 (-142)
• Total: 9.5 -- Over: (+102) | Under: (-124)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 2-3, 4.15 ERA vs JP Sears (Athletics) - 5-6, 5.45 ERA

The probable pitchers are Slade Cecconi (2-3) for the Guardians and JP Sears (5-6) for the Athletics. Cecconi's team is 4-2-0 against the spread in his starts this season. Cecconi's team is 1-1 this season when he starts and they're favored on the moneyline. The Athletics are 8-7-0 ATS in Sears' 15 starts with a set spread. The Athletics are 2-7 in Sears' nine starts this season that they were the underdog on the moneyline.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (53.2%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -134 favorite, while the Athletics are a +114 underdog at home.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +118 to cover, while the Athletics are -142 to cover.

Guardians vs Athletics Over/Under

• Guardians versus Athletics on June 22 has an over/under of 9.5 runs, with the odds on the over +102 and the under set at -124.

Bet on Cleveland Guardians vs. Athletics on FanDuel today!

Guardians vs Athletics Betting Trends

• The Guardians have come away with 15 wins in the 25 contests they have been listed as the favorites in this season.
• This year, the Guardians have won eight of 11 games when listed as at least -134 or better on the moneyline.
• The Guardians and their opponents have hit the over in 31 of their 73 games with a total this season.
• In 73 games with a line this season, the Guardians have a mark of 37-36-0 against the spread.
• The Athletics have a 21-38 record in games they were listed as the moneyline underdog (winning 35.6% of those games).
• The Athletics have gone 11-31 in games they have played as a moneyline underdog with odds of +114 or longer (26.2%).
• The Athletics have played in 79 games with a set over/under, and have combined with their opponents to go over the total 43 times (43-33-3).
• The Athletics have put together a 38-41-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez has 89 hits and an OBP of .385 to go with a slugging percentage of .531. All three of those stats rank first among Cleveland hitters this season. He has a .324 batting average, as well.
• Among qualifying hitters, he ranks sixth in batting average, his on-base percentage ranks 13th, and he is 11th in slugging.
• Ramirez hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .316 with a double, two walks and two RBIs.
• Steven Kwan is batting .305 with 17 doubles, six home runs and 25 walks. He's slugging .430 with an on-base percentage of .366.
• He ranks 13th in batting average, 30th in on-base percentage and 79th in slugging among qualifying batters.
• Kwan brings a three-game streak with at least one hit into this contest. In his last five games he is batting .368 with three doubles, two walks and an RBI.
• Carlos Santana has collected 59 base hits, an OBP of .329 and a slugging percentage of .356 this season.
• Kyle Manzardo is batting .217 with a .297 OBP and 31 RBI for Cleveland this season.

Athletics Player Leaders

• Jacob Wilson has a team-best OBP (.392) and slugging percentage (.498), and paces the Athletics in hits (102, while batting .353).
• Including all the qualified hitters in the big leagues, his batting average ranks second, his on-base percentage ranks ninth, and he is 22nd in slugging.
• Brent Rooker is hitting .272 with 16 doubles, two triples, 15 home runs and 35 walks. He's slugging .482 with an on-base percentage of .350.
• Including all qualifying hitters, his batting average puts him 46th, his on-base percentage ranks 50th, and he is 32nd in slugging.
• Tyler Soderstrom has 11 doubles, a triple, 14 home runs and 33 walks while batting .249.
• Lawrence Butler is hitting .261 with 23 doubles, a triple, 11 home runs and 27 walks.

Guardians vs Athletics Head to Head

• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/20/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/19/2024: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2024: 4-3 OAK (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/30/2024: 12-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/29/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/28/2024: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/22/2023: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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