Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 2

Odds updated as of 2:11 p.m.

The Friday slate in MLB includes a matchup between the Houston Astros and the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Astros vs White Sox Game Info

• Houston Astros (16-14) vs. Chicago White Sox (8-23)
• Date: Friday, May 2, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SCHN

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-240) | CHW: (+194)
• Spread: HOU: -1.5 (-138) | CHW: +1.5 (+115)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Framber Valdez (Astros) - 1-3, 4.00 ERA vs Jonathan Cannon (White Sox) - 1-3, 4.50 ERA

This contest's pitching matchup is set, as the Astros will send Framber Valdez (1-3) to the mound, while Jonathan Cannon (1-3) will get the nod for the White Sox. Valdez's team is 3-3-0 against the spread this season in his starts. Valdez's team has won 20% of his starts when they are favored on the moneyline (1-4). The White Sox have gone 1-4-0 ATS in Cannon's five starts with a set spread. The White Sox were the underdog on the moneyline for five Cannon starts this season -- they lost each time.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (65.3%)

Astros vs White Sox Moneyline

• Houston is a -240 favorite on the moneyline, while Chicago is a +194 underdog at home.

Astros vs White Sox Spread

• The Astros are at the White Sox and are favored by 1.5 runs on the spread. The Astros are -138 to cover the runline, with the White Sox being +115.

Astros vs White Sox Over/Under

• The Astros-White Sox game on May 2 has been given an over/under of 7.5 runs. The over is set at -120 and the under at -102.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have been victorious in 11, or 52.4%, of the 21 contests they have been chosen as favorites in this season.
• Oddsmakers have given Houston the best odds of winning it has seen this season, with a -240 moneyline listed for this contest.
• The Astros and their opponents have gone over the total this season in 12 of their 30 opportunities.
• The Astros are 17-13-0 against the spread in their 30 games with a line set by sportsbooks this season.
• The White Sox have been the moneyline underdog 31 total times this season. They've gone 8-23 in those games.
• Chicago has a 1-8 record (winning only 11.1% of its games) when playing as a moneyline underdog of +194 or longer.
• The White Sox have combined with opponents to hit the over on the total 14 times this season for a 14-15-2 record against the over/under.
• The White Sox have a 16-15-0 record against the spread this season (covering 51.6% of the time).

Astros Player Leaders

• Jeremy Pena leads Houston in total hits (31) this season while batting .282 with nine extra-base hits. He has an on-base percentage of .355 and a slugging percentage of .436.
• He is 39th in batting average, 49th in on-base percentage, and 62nd in slugging among all qualifying hitters in MLB.
• Pena has hit safely in five straight games. In his last five games he is batting .450 with two doubles, a home run, two walks and four RBI.
• Isaac Paredes leads Houston in OBP (.362) this season, fueled by 28 hits. He's batting .252 while slugging .405.
• Among qualifying hitters, his batting average ranks him 76th, his on-base percentage 42nd, and his slugging percentage 89th.
• Paredes has picked up a hit in three games in a row. During his last five outings he is hitting .294 with a double, a triple, five walks and an RBI.
• Jose Altuve has an OPS of .725, fueled by an OBP of .323 and a team-best slugging percentage of .402 this season.
• Yordan Alvarez has been key for Houston with 21 hits, an OBP of .316 plus a slugging percentage of .354.
• Alvarez takes a three-game hitting streak into this matchup. In his last five games he is batting .211 with a double, a home run, two walks and five RBI.

White Sox Player Leaders

• Luis Robert has three doubles, four home runs and 17 walks while batting .183. He's slugging .327 with an on-base percentage of .295.
• Including all the qualified players in the majors, he ranks 155th in batting average, 116th in on-base percentage and 136th in slugging percentage.
• Robert brings a six-game hitting streak into this matchup. In his last 10 games he is hitting .231 with two doubles, two home runs, five walks and seven RBI.
• Andrew Benintendi is batting .231 with five home runs and eight walks. He's slugging .423 with an on-base percentage of .310.
• Miguel Vargas has put up an on-base percentage of .311, a team-high for the White Sox.
• Brooks Baldwin has five doubles, three home runs and four walks while batting .241.

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