Astros vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 20

Odds updated as of 7:12 p.m.

The MLB schedule on Saturday includes the Houston Astros taking on the Cleveland Guardians.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Guardians Game Info

• Houston Astros (36-41) vs. Cleveland Guardians (40-36)
• Date: Saturday, June 20, 2026
• Time: 7:15 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: FOX

Astros vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-124) | CLE: (+106)
• Spread: HOU: +1.5 (-210) | CLE: -1.5 (+172)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Astros vs Guardians Probable Starting Pitchers

Probable Pitchers: Spencer Arrighetti (Astros) - 7-2, 2.57 ERA vs Joey Cantillo (Guardians) - 5-3, 4.37 ERA

The probable starters are Spencer Arrighetti (7-2) for the Astros and Joey Cantillo (5-3) for the Guardians. Arrighetti and his team are 8-3-0 ATS this season when he starts. Arrighetti's team is 2-0 this season when he starts and they're favored on the moneyline. The Guardians have an 11-4-0 record against the spread in Cantillo's starts. The Guardians have a 7-2 record in Cantillo's nine starts this season when they were the underdog on the moneyline.

Astros vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.6%)

Astros vs Guardians Moneyline

• Looking at the moneyline for Astros-Guardians, Houston is the favorite at -124, and Cleveland is +106 playing on the road.

Astros vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Astros. The Guardians are +172 to cover, while the Astros are -210 to cover as a 1.5-run underdog on the runline.

Astros vs Guardians Over/Under

• The over/under for Astros-Guardians on June 20 is 8.5. The over is -104, and the under is -118.

Bet on Houston Astros vs. Cleveland Guardians on FanDuel today!

Astros vs Guardians Betting Trends

• The Astros have come away with 11 wins in the 25 contests they have been listed as the favorites in this season.
• Houston has a record of 9-11 in contests when oddsmakers favor them by -124 or more on the moneyline.
• The Astros' games have gone over the total in 41 of their 77 opportunities.
• The Astros are 36-41-0 against the spread in their 77 games with a line set by sportsbooks this season.
• The Guardians have gone 18-16 in games they were listed as the moneyline underdog (winning 52.9% of those games).
• Cleveland has a 14-11 record (winning 56% of its games) when it has played as a moneyline underdog of +106 or longer.
• The Guardians have played in 72 games with an over/under set, and have combined with their opponents to go over the total 36 times (36-36-0).
• The Guardians have collected a 37-35-0 record against the spread this season.

Astros Player Leaders

• Yordan Alvarez has 90 hits and an OBP of .428 to go with a slugging percentage of .637. All three of those stats rank first among Houston hitters this season. He has a .324 batting average, as well.
• Among qualifying hitters in the majors, he is third in batting average, second in on-base percentage, and first in slugging.
• Alvarez has hit safely in nine games in a row. In his last 10 outings he is hitting .366 with two doubles, two home runs, three walks and seven RBIs.
• Christian Walker is batting .242 with 14 doubles, a triple, 18 home runs and 26 walks. He's slugging .488 with an on-base percentage of .313.
• His batting average ranks 100th among qualified players, his on-base percentage 108th, and his slugging percentage 31st.
• Isaac Paredes has collected 59 base hits, an OBP of .344 and a slugging percentage of .415 this season.
• Paredes enters this game with four games in a row with at least one hit. In his last five games he is batting .313 with two doubles, a home run, three walks and three RBIs.
• Jeremy Pena is batting .289 with a .351 OBP and 18 RBI for Houston this season.
• Pena enters this game on a four-game hitting streak. In his last five games he is hitting .348 with a double, three home runs and six RBIs.

Guardians Player Leaders

• Brayan Rocchio has accumulated an on-base percentage of .353 and a slugging percentage of .399. Both lead the Guardians. He's batting .273.
• Including all qualifying hitters in MLB, his batting average puts him 49th, his on-base percentage is 50th, and he is 101st in slugging.
• Steven Kwan has eight doubles, a home run and 37 walks while batting .210. He's slugging .256 with an on-base percentage of .319.
• He ranks 145th in batting average, 97th in on-base percentage and 157th in slugging percentage in MLB.
• Travis Bazzana is hitting .256 with 11 doubles, a triple, five home runs and 24 walks.
• Rhys Hoskins has 12 doubles, seven home runs and 35 walks while hitting .179.

Astros vs Guardians Head to Head

• 6/19/2026: 9-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/22/2026: 2-0 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/21/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/20/2026: 9-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/9/2025: 4-2 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/8/2025: 10-6 CLE (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/7/2025: 7-5 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/8/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/7/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/6/2025: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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