Astros vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 19

Odds updated as of 10:11 p.m.

The Houston Astros will take on the St. Louis Cardinals in MLB action on Sunday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Cardinals Game Info

• Houston Astros (8-13) vs. St. Louis Cardinals (11-8)
• Date: Sunday, April 19, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Cardinals.TV

Astros vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-142) | STL: (+120)
• Spread: HOU: -1.5 (+146) | STL: +1.5 (-176)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Astros vs Cardinals Probable Starting Pitchers

Probable Pitchers: Mike Burrows (Astros) - 1-3, 6.55 ERA vs Matthew Liberatore (Cardinals) - 0-1, 4.29 ERA

The Astros will give the ball to Mike Burrows (1-3, 6.55 ERA), who is eyeing win No. 2 on the season, and the Cardinals will counter with Matthew Liberatore (0-1, 4.29 ERA). When Burrows starts, his team is 1-3-0 against the spread this season. Burrows' team is 0-2 this season when he starts and they're favored on the moneyline. The Cardinals have a 2-2-0 record against the spread in Liberatore's starts. The Cardinals are 3-1 in Liberatore's four starts this season that they were the underdog on the moneyline.

Astros vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (57.9%)

Astros vs Cardinals Moneyline

• Houston is a -142 favorite on the moneyline, while St. Louis is a +120 underdog on the road.

Astros vs Cardinals Spread

• The Astros are 1.5-run home favorites on the runline against the Cardinals. The Astros are +146 to cover, and the Cardinals are -176.

Astros vs Cardinals Over/Under

• An over/under of 8.5 has been set for Astros-Cardinals on April 19, with the over being -118 and the under -104.

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Astros vs Cardinals Betting Trends

• The Astros have come away with five wins in the 13 contests they have been listed as the favorites in this season.
• Houston has a record of 4-6 in contests when bookmakers favor them by -142 or more on the moneyline.
• The Astros' games have gone over the total in 14 of their 21 opportunities.
• The Astros are 8-13-0 against the spread in their 21 games with a line set by sportsbooks this season.
• The Cardinals have put together a 9-7 record in games they were listed as the moneyline underdog (winning 56.2% of those games).
• St. Louis has a record of 2-3 in games it has played as a moneyline underdog with odds of +120 or longer (40%).
• The Cardinals have combined with opponents to hit the over on the total 11 times this season for an 11-7-1 record against the over/under.
• The Cardinals have put together a 10-9-0 record ATS this season (covering 52.6% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.479), slugging percentage (.750) and total hits (24) this season. He has a .333 batting average.
• Among all qualified hitters in the majors, he is eighth in batting average, first in on-base percentage, and second in slugging.
• Alvarez has picked up at least one hit in four straight games. During his last five outings he is hitting .316 with two doubles, two home runs, three walks and five RBIs.
• Christian Walker has six doubles, four home runs and 10 walks. He's batting .278 and slugging .528 with an on-base percentage of .369.
• He ranks 51st in batting average, 41st in on-base percentage and 27th in slugging among qualifying hitters.
• Jose Altuve is batting .293 with a .493 slugging percentage and seven RBI this year.
• Altuve enters this matchup with two games in a row with at least one hit. During his last five outings he is hitting .273 with two doubles, a home run, a walk and an RBI.
• Cam Smith is batting .264 with a .349 OBP and 10 RBI for Houston this season.

Cardinals Player Leaders

• Jordan Walker has racked up a slugging percentage of .685 and has 23 hits, both team-high numbers for the Cardinals. He's batting .315 and with an on-base percentage of .375.
• Including all the qualifying hitters in the big leagues, his batting average ranks 18th, his on-base percentage is 38th, and he is fourth in slugging.
• Jordan Walker takes a 12-game hitting streak into this game. During his last 10 games he is hitting .326 with a double, six home runs, three walks and eight RBIs.
• Alec Burleson is hitting .292 with four doubles, two home runs and 12 walks. He's slugging .431 with an on-base percentage of .388.
• Including all qualifying hitters, his batting average places him 35th, his on-base percentage is 28th, and he is 72nd in slugging.
• JJ Wetherholt is batting .232 with a double, three home runs and 13 walks.
• Ivan Herrera has a .398 OBP to lead his team.

Astros vs Cardinals Head to Head

• 4/17/2026: 9-4 STL (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/16/2025: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/15/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/14/2025: 8-3 STL (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2024: 4-2 STL (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/4/2024: 8-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/3/2024: 7-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 6/29/2023: 14-0 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/28/2023: 10-7 HOU (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/27/2023: 4-2 STL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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