Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for July 29

Odds updated as of 5:12 a.m.

Wednesday's slate in the MLB includes a matchup between the Houston Astros and the Los Angeles Angels.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Astros vs Angels Game Info

• Houston Astros (54-55) vs. Los Angeles Angels (42-66)
• Date: Wednesday, July 29, 2026
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: ABTV and SCHN

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-138) | LAA: (+118)
• Spread: HOU: -1.5 (+116) | LAA: +1.5 (-140)
• Total: 9.5 -- Over: (-115) | Under: (-105)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Hayden Wesneski (Astros) - 0-0, 0.00 ERA vs Grayson Rodriguez (Angels) - 3-3, 8.54 ERA

This contest's pitching matchup is set, as the Astros will send Hayden Wesneski to the mound, while Grayson Rodriguez (3-3) will get the nod for the Angels. In games Wesneski pitched with a spread last season, his team was 4-2-0 ATS. Wesneski and his team won as favorites in 50% of his two appearances last season with a moneyline. The Angels have gone 5-4-0 ATS in Rodriguez's nine starts with a set spread. The Angels are 3-5 in Rodriguez's eight starts this season that they were the underdog on the moneyline.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.3%)

Astros vs Angels Moneyline

• Houston is the favorite, -138 on the moneyline, while Los Angeles is a +118 underdog despite being at home.

Astros vs Angels Spread

• The Astros are 1.5-run road favorites on the runline against the Angels. The Astros are +116 to cover, and the Angels are -140.

Astros vs Angels Over/Under

• The over/under for the Astros versus Angels contest on July 29 has been set at 9.5, with -115 odds on the over and -105 odds on the under.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have been victorious in 19, or 48.7%, of the 39 contests they have been chosen as favorites in this season.
• Houston has a record of 6-12 in contests when bookmakers favor them by -138 or more on the moneyline.
• The Astros and their opponents have hit the over in 57 of their 109 games with a total set by oddsmakers this season.
• The Astros are 53-56-0 against the spread in their 109 games that had a posted line this season.
• The Angels have been the underdog on the moneyline 81 total times this season. They've gone 29-52 in those games.
• In games it has played as a moneyline underdog with odds of +118 or longer, Los Angeles has gone 17-32 (34.7%).
• The Angels have played in 107 games with a set over/under, and have combined with their opponents to go over the total 48 times (48-57-2).
• The Angels have gone 56-51-0 ATS this season.

Astros Player Leaders

• Yordan Alvarez leads Houston with 126 hits and an OBP of .435, plus a team-best slugging percentage of .647. He's batting .325.
• He is second in batting average, first in on-base percentage, and first in slugging among all qualifying batters in baseball.
• Alvarez hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .250 with a home run, six walks and three RBIs.
• Isaac Paredes has 18 doubles, a triple, 14 home runs and 41 walks. He's batting .255 and slugging .421 with an on-base percentage of .349.
• Among all qualifying hitters, he ranks 75th in batting average, 49th in on-base percentage and 83rd in slugging percentage.
• Christian Walker is batting .235 with a .455 slugging percentage and 62 RBI this year.
• Walker enters this game with two games in a row with at least one hit. In his last five games he is hitting .263 with a double, a home run, two walks and four RBIs.
• Jeremy Pena has 11 home runs, 30 RBI and a batting average of .314 this season.
• Pena brings a 10-game hitting streak into this game. In his last 10 outings he is hitting .439 with a double, five home runs, two walks and eight RBIs.

Angels Player Leaders

• Mike Trout has racked up 78 hits with a .394 on-base percentage, leading the Angels in both categories. He's batting .244 and slugging .459.
• Including all the qualifying hitters in MLB, his batting average puts him 100th, his on-base percentage ranks fifth, and he is 46th in slugging.
• Zach Neto is hitting .234 with 21 doubles, three triples, 19 home runs and 48 walks. He's slugging .437 with an on-base percentage of .325.
• His batting average is 119th among all qualified players, his on-base percentage is 86th, and he is 69th in slugging.
• Jo Adell has racked up a slugging percentage of .401, a team-best for the Angels.
• Nolan Schanuel has 18 doubles, six home runs and 33 walks while hitting .279.

Astros vs Angels Head to Head

• 7/28/2026: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/27/2026: 6-4 HOU (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/10/2026: 3-2 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/9/2026: 10-1 LAA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/8/2026: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 3/29/2026: 9-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 3/28/2026: 11-9 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/27/2026: 6-2 LAA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 3/26/2026: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/28/2025: 6-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)

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