Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for March 27

Odds updated as of 5:13 a.m.

In MLB action on Friday, the Houston Astros take on the Los Angeles Angels.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Astros vs Angels Game Info

• Houston Astros (0-1) vs. Los Angeles Angels (1-0)
• Date: Friday, March 27, 2026
• Time: 8:15 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: Apple TV+

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-168) | LAA: (+142)
• Spread: HOU: -1.5 (+128) | LAA: +1.5 (-154)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Mike Burrows (Astros) - 0-0, 0.00 ERA vs Yusei Kikuchi (Angels) - 0-0, 0.00 ERA

The Astros will give the nod to Mike Burrows against the Angels and Yusei Kikuchi. In 19 games he pitched with a spread last season, Burrows and his team finished with an 11-8-0 record ATS. Burrows and his team were 3-3 when he pitched and they were the moneyline favorite. Last season Kikuchi and his team went 18-15-0 against the spread when he pitched. Kikuchi and his team went 7-14 in games he pitched when they were moneyline underdogs a season ago.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (66%)

Astros vs Angels Moneyline

• The moneyline numbers for Astros vs. Angels reveal Houston as the favorite (-168) and Los Angeles as the underdog (+142) on the road.

Astros vs Angels Spread

• The Astros are favored by 1.5 runs at home versus the Angels. The Astros are +128 to cover the spread, while the Angels are -154.

Astros vs Angels Over/Under

• An over/under of 8.5 has been set for Astros-Angels on March 27, with the over being -110 and the under -110.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros came away with 53 wins in the 99 contests they were listed as the favorites last season.
• Last season Houston came away with a win nine times in 18 chances when named as a favorite of at least -168 or shorter on the moneyline.
• The Astros and their opponents hit the over in 72 of their 161 games with a total last season.
• The Angels went 52-69 in games they were listed as the moneyline underdog last season (winning 43% of those games).
• Los Angeles went 18-24 in games it played as a moneyline underdog with odds of +142 or longer (42.9%).
• The Angels played in 160 games with an over/under set last season, and combined with their opponents to go over the total 84 times (84-71-5).

Astros Player Leaders

• Last season, Jose Altuve finished with a slugging percentage of .442, fueled by 51 extra-base hits.
• Jeremy Pena finished with an OBP of .363 and 150 total hits.
• Yainer Diaz ended his last campaign with 139 hits, an OBP of .284, plus a slugging percentage of .417.
• Christian Walker slashed .238/.297/.421 and finished with an OPS of .717.

Angels Player Leaders

• Jo Adell racked up 124 hits with a batting average of .236 last season.
• Nolan Schanuel had a .389 slugging percentage while batting .264.
• Zach Neto put up a .474 slugging percentage and a .257 batting average last year.
• Mike Trout had a .359 OBP and batted .232.

Astros vs Angels Head to Head

• 3/26/2026: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/28/2025: 6-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/27/2025: 6-1 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/26/2025: 4-3 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/1/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/31/2025: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/30/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/22/2025: 8-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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