Trevor Lawrence Fantasy Football Week 4: Stats and Projections vs. 49ers

In Week 4 (Sunday at 4:05 p.m. ET), quarterback Trevor Lawrence and the Jacksonville Jaguars will meet the San Francisco 49ers, who have the fifth-ranked passing defense in the NFL (162 yards conceded per game).

Is Lawrence a DFS option for you this week, as he goes up against the 49ers? More stats and information can be found below, so take a look.

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Trevor Lawrence Week 4 Fantasy Football Projection

• Matchup: Jacksonville Jaguars at San Francisco 49ers
• Game Date: September 28, 2025
• Game Time: 4:05 p.m.
• Projected Fantasy Points: 14.7
• Projected Passing Yards: 225.91
• Projected Passing TDs: 1.37
• Projected Rushing Yards: 12.38
• Projected Rushing TDs: 0.14

Projections provided by numberFire

Lawrence Fantasy Performance

• Lawrence is the 23rd-ranked fantasy player at the QB position and 47th overall, as he has posted 37.3 total fantasy points (12.4 per game).
• Last week against the Houston Texans, Lawrence put up 7.8 fantasy points, racking up 222 passing yards with zero touchdowns and one pick while chipping in nine rushing yards with his legs.

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49ers Defensive Performance

• San Francisco is yet to allow a player to throw for more than 300 yards passing in a game this season.
• The 49ers have allowed two players to pass for at least one TD in a game this season.
• A total of one player has thrown for at least two TDs against San Francisco this year.
• The 49ers have allowed one player to throw for three or more touchdowns in a game this season.
• A total of one player has put up over 100 yards receiving in a game versus San Francisco this season.
• A total of Four players have caught a touchdown pass versus the 49ers this season.
• San Francisco has not given up more than one touchdown reception to an opposing player this year.
• The 49ers have not allowed more than 100 yards rushing to an opposing player this season.
• San Francisco has given up at least one rushing TD to one player this year.
• The 49ers have not allowed an opposing player to score more than one rushing TD against them this year.

Want more data and analysis on Trevor Lawrence? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.