Southern Miss vs Jacksonville State Prediction, Odds, Picks, Best Bets for Week 5 2025

The Southern Miss Golden Eagles are among the college football teams in action on Saturday, versus the Jacksonville State Gamecocks.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Southern Miss vs Jacksonville State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Southern Miss: (-184) | Jacksonville State: (+152)
• Spread: Southern Miss: -3.5 (-122) | Jacksonville State: +3.5 (100)
• Total: 55.5 -- Over: (-115) | Under: (-105)

Southern Miss vs Jacksonville State Betting Trends

• Southern Miss has two wins against the spread this year.
• Southern Miss is unbeaten ATS (1-0) as a 3.5-point favorite or greater this year.
• Two of four Southern Miss games have gone over the point total this year.
• Jacksonville State has posted two wins against the spread this year.
• Jacksonville State has two wins ATS (2-1) as a 3.5-point underdog or more this season.
• Jacksonville State has played two games (out of four) which finished over the total this year.

Southern Miss vs Jacksonville State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Gamecocks win (64.3%)

Southern Miss vs Jacksonville State Point Spread

Jacksonville State is the underdog by 3.5 points against Southern Miss. Jacksonville State is -122 to cover the spread, and Southern Miss is +100.

Southern Miss vs Jacksonville State Over/Under

The Southern Miss-Jacksonville State game on Sept. 27 has been given an over/under of 55.5 points. The over is -115 and the under is -105.

Southern Miss vs Jacksonville State Moneyline

Jacksonville State is the underdog, +152 on the moneyline, while Southern Miss is a -184 favorite.

Southern Miss vs. Jacksonville State Points Insights

Southern Miss vs. Jacksonville State Game Info

• Game day: Saturday, September 27, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN+
• Location: Hattiesburg, Mississippi
• Stadium: M.M. Roberts Stadium

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Check out even more in-depth Southern Miss vs. Jacksonville State analysis on FanDuel Research.