Red Sox vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 11:11 a.m.

On Monday in MLB, the Boston Red Sox are playing the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Red Sox vs White Sox Game Info

• Boston Red Sox (12-11) vs. Chicago White Sox (5-16)
• Date: Monday, April 21, 2025
• Time: 11:10 a.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CHSN

Red Sox vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-290) | CHW: (+235)
• Spread: BOS: -1.5 (-142) | CHW: +1.5 (+118)
• Total: 9 -- Over: (-112) | Under: (-108)

Red Sox vs White Sox Probable Starting Pitchers

Probable Pitchers: Walker Anthony Buehler (Red Sox) - 2-1, 5.23 ERA vs Jonathan Cannon (White Sox) - 0-2, 4.42 ERA

The probable pitchers are Walker Anthony Buehler (2-1) for the Red Sox and Jonathan Cannon (0-2) for the White Sox. When Buehler starts, his team is 2-2-0 against the spread this season. Buehler's team is 2-0 this season when he starts and they're favored on the moneyline. The White Sox have gone 1-3-0 against the spread when Cannon starts. The White Sox were named the moneyline underdog for four Cannon starts this season -- they lost every time.

Red Sox vs White Sox Moneyline

• Looking at the moneyline for White Sox-Red Sox, Chicago is the underdog at +235, and Boston is -290 playing at home.

Red Sox vs White Sox Spread

• The Red Sox are hosting the White Sox and are favored by 1.5 runs on the spread. The Red Sox are -142 to cover the runline, with the White Sox being +118.

Red Sox vs White Sox Over/Under

• Red Sox versus White Sox on April 21 has an over/under of 9 runs, with the odds on the over -112 and the under set at -108.

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Red Sox vs White Sox Betting Trends

• The Red Sox have been chosen as favorites in 16 games this year and have walked away with the win nine times (56.2%) in those games.
• Boston has been listed as a favorite of -290 or more on two occasions this season and split those games.
• The Red Sox's games have gone over the total in nine of their 23 opportunities.
• In 23 games with a line this season, the Red Sox have a mark of 11-12-0 against the spread.
• The White Sox have won 23.8% of the games this season they were the moneyline underdog (5-16).
• Chicago has played as a moneyline underdog of +235 or longer in just one game this season, which it lost.
• The White Sox have played in 21 games with an over/under set, and have combined with opponents to go over the total nine times (9-10-2).
• The White Sox have covered 52.4% of their games this season, going 11-10-0 against the spread.

Red Sox Player Leaders

• Alexander David Bregman is batting .292 with seven doubles, four home runs and seven walks. He has an on-base percentage of .360 while slugging .506.
• Among all qualifying batters in MLB, he ranks 40th in batting average, 46th in on-base percentage, and 32nd in slugging.
• Wilyer Abreu leads the Red Sox in OBP (.405) and total hits (20) this season. He's batting .286 while slugging .529.
• Among all qualified, he ranks 48th in batting average, 15th in on-base percentage and 25th in slugging percentage.
• Trevor Story leads Boston in slugging percentage (.518) powered by seven extra-base hits.
• Story enters this game with two games in a row with at least one hit. In his last five games he is batting .350 with two home runs, a walk and six RBI.
• Kristian Campbell has been key for Boston with 22 hits, an OBP of .402 plus a slugging percentage of .493.
• Campbell has hit safely in two straight games. In his last five games he is batting .278 with a double, a home run, three walks and an RBI.

White Sox Player Leaders

• Luis Robert is batting .154 with a double, two home runs and 12 walks. He's slugging .262 with an on-base percentage of .282.
• Including all qualifying hitters in MLB, he is 169th in batting average, 128th in on-base percentage and 161st in slugging percentage.
• Andrew Sebastian Benintendi has three home runs and three walks while hitting .217. He's slugging .413 with an on-base percentage of .265.
• Matt Thaiss has two doubles, a home run and nine walks while hitting .229.
• Brooks Baldwin is hitting .255 with a double, two home runs and a walk.

Red Sox vs White Sox Head to Head

• 4/20/2025: 8-4 CHW (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 4/19/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -350, Underdog Moneyline: +280)
• 4/18/2025: 10-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/13/2025: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 4/12/2025: 3-2 CHW (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/11/2025: 11-1 CHW (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/8/2024: 7-2 CHW (Favorite: Red Sox, Spread: -1.5, Total: 10, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 9/7/2024: 7-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/6/2024: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 6/9/2024: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)

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