Red Sox vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 1:11 p.m.

On Friday in MLB, the Boston Red Sox are up against the Baltimore Orioles.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Orioles Game Info

• Boston Red Sox (25-26) vs. Baltimore Orioles (16-32)
• Date: Friday, May 23, 2025
• Time: 1:35 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: MLB Network, NESN, and MASN

Red Sox vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-130) | BAL: (+110)
• Spread: BOS: -1.5 (+140) | BAL: +1.5 (-170)
• Total: 9.5 -- Over: (-115) | Under: (-105)

Red Sox vs Orioles Probable Starting Pitchers

Probable Pitchers: Brayan Bello (Red Sox) - 2-1, 4.02 ERA vs Cade Povich (Orioles) - 1-3, 5.23 ERA

The Red Sox will give the nod to Brayan Bello (2-1) against the Orioles and Cade Povich (1-3). Bello and his team are 4-2-0 ATS this season when he starts. Bello's team has won each of the four games he's started as the moneyline favorite. When Povich starts, the Orioles are 2-6-0 against the spread. The Orioles are 1-2 in Povich's three starts this season that they were the moneyline underdog.

Red Sox vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (54.2%)

Red Sox vs Orioles Moneyline

• The Red Sox vs Orioles moneyline has Boston as a -130 favorite, while Baltimore is a +110 underdog on the road.

Red Sox vs Orioles Spread

• The Red Sox are hosting the Orioles and are favored by 1.5 runs (+140 to cover) on the runline. Baltimore is -170 to cover.

Red Sox vs Orioles Over/Under

• Red Sox versus Orioles, on May 23, has an over/under of 9.5, with the over being -115 and the under -105.

Bet on Boston Red Sox vs. Baltimore Orioles on FanDuel today!

Red Sox vs Orioles Betting Trends

• The Red Sox have been favorites in 36 games this season and have come away with the win 18 times (50%) in those contests.
• This season Boston has come away with a win eight times in 17 chances when named as a favorite of at least -130 on the moneyline.
• The Red Sox and their opponents have hit the over in 24 of their 51 games with a total set by oddsmakers this season.
• The Red Sox are 26-25-0 against the spread in their 51 games with a line set by sportsbooks this season.
• The Orioles have been the moneyline underdog 20 total times this season. They've gone 7-13 in those games.
• Baltimore has played seven times as a moneyline underdog with odds of +110 or longer, and lost each game.
• The Orioles have played in 48 games with a set over/under, and have combined with their opponents to go over the total 24 times (24-22-2).
• The Orioles have a 15-33-0 record ATS this season.

Red Sox Player Leaders

• Alex Bregman leads Boston in slugging percentage (.554) and total hits (58) this season. He's batting .297 with an on-base percentage of .381.
• Among all qualified batters in MLB, he is 22nd in batting average, 19th in on-base percentage, and 10th in slugging.
• Rafael Devers has 54 hits this season and a team-best OBP of .409. He's batting .287 and slugging .521.
• Among qualifying batters, his batting average places him 32nd, his on-base percentage fifth, and his slugging percentage 20th.
• Devers brings a two-game streak with at least one hit into this contest. In his last five games he is batting .438 with two doubles, three home runs, five walks and seven RBIs.
• Wilyer Abreu has 43 hits this season and has a slash line of .257/.344/.503.
• Jarren Duran has three home runs, 29 RBI and a batting average of .265 this season.

Orioles Player Leaders

• Cedric Mullins is batting .236 with nine doubles, 10 home runs and 22 walks. He's slugging .473 with an on-base percentage of .332.
• Including all qualifying hitters, he is 109th in batting average, while his on-base percentage ranks 75th and he is 45th in slugging.
• Mullins heads into this game on a four-game hitting streak. In his last five games he is hitting .316 with two doubles, two home runs, a walk and six RBIs.
• Ryan O'Hearn's 41 hits and .396 on-base percentage both lead his team. He has a batting average of .306 while slugging .507.
• Including all qualifying hitters, he ranks 12th in batting average, eighth in on-base percentage and 26th in slugging percentage.
• Adley Rutschman is hitting .213 with seven doubles, a triple, five home runs and 19 walks.
• Jackson Holliday is batting .268 with four doubles, two triples, six home runs and 10 walks.

Red Sox vs Orioles Head to Head

• 4/3/2025: 8-4 BOS (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/2/2025: 3-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 3/31/2025: 8-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/11/2024: 5-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/10/2024: 5-3 BAL (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/9/2024: 12-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/18/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/16/2024: 12-10 BOS (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/15/2024: 5-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/29/2024: 6-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)

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