Red Sox vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 6:11 a.m.

The Boston Red Sox are among the MLB squads busy on Thursday, up against the Baltimore Orioles.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs Orioles Game Info

• Boston Red Sox (25-26) vs. Baltimore Orioles (16-32)
• Date: Thursday, May 22, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: MLB Network, NESN, and MASN

Red Sox vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-122) | BAL: (+104)
• Spread: BOS: +1.5 (-205) | BAL: -1.5 (+168)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Red Sox vs Orioles Probable Starting Pitchers

Probable Pitchers: Lucas Giolito (Red Sox) - 1-1, 7.08 ERA vs Cade Povich (Orioles) - 1-3, 5.23 ERA

This contest's pitching matchup is set, as the Red Sox will send Lucas Giolito (1-1) to the mound, while Cade Povich (1-3) will get the nod for the Orioles. Giolito and his team are 2-2-0 ATS this season when he starts. Giolito's team is 1-1 this season when he starts and they're favored on the moneyline. The Orioles have a 2-6-0 ATS record in Povich's eight starts with a set spread. The Orioles are 1-2 in Povich's three starts this season that they were the moneyline underdog.

Red Sox vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (50.5%)

Red Sox vs Orioles Moneyline

• The Red Sox vs Orioles moneyline has Boston as a -122 favorite, while Baltimore is a +104 underdog on the road.

Red Sox vs Orioles Spread

• The Orioles are 1.5-run favorites against the spread for this matchup with the Red Sox. The Orioles are +168 to cover, while the Red Sox are -205 to cover as a 1.5-run underdog on the runline.

Red Sox vs Orioles Over/Under

• A combined run total of 8.5 has been set for Red Sox-Orioles on May 22, with the over at -118 and the under at -104.

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Red Sox vs Orioles Betting Trends

• The Red Sox have come away with 18 wins in the 36 contests they have been listed as the favorites in this season.
• Boston has a record of 12-10 in contests when bookmakers favor them by -122 or more on the moneyline.
• The Red Sox and their opponents have gone over the total this season in 24 of their 51 opportunities.
• In 51 games with a line this season, the Red Sox have a mark of 26-25-0 against the spread.
• The Orioles are 7-13 in games they were listed as the moneyline underdog (winning 35% of those games).
• Baltimore has a record of 3-9 when playing as a moneyline underdog with odds of +104 or longer (25%).
• The Orioles have played in 48 games with an over/under set, and have combined with their opponents to go over the total 24 times (24-22-2).
• The Orioles have collected a 15-33-0 record ATS this season.

Red Sox Player Leaders

• Alex Bregman leads Boston with 58 hits and a team-best slugging percentage of .554. He's batting .297 with an on-base percentage of .381.
• Among all qualified hitters, he ranks 22nd in batting average, his on-base percentage ranks 19th, and he is ninth in slugging.
• Rafael Devers leads Boston in OBP (.409) this season, fueled by 54 hits. He's batting .287 while slugging .521.
• His batting average is 33rd among qualified players, his on-base percentage fifth, and his slugging percentage 21st.
• Devers heads into this game looking to extend his two-game hit streak. During his last five outings he is hitting .438 with two doubles, three home runs, five walks and seven RBIs.
• Wilyer Abreu has collected 43 base hits, an OBP of .344 and a slugging percentage of .503 this season.
• Jarren Duran is batting .265 with a .313 OBP and 29 RBI for Boston this season.

Orioles Player Leaders

• Cedric Mullins is batting .236 with nine doubles, 10 home runs and 22 walks. He's slugging .473 with an on-base percentage of .332.
• Including all the qualifying hitters in the big leagues, his batting average is 109th, his on-base percentage ranks 76th, and he is 46th in slugging.
• Mullins brings a four-game hitting streak into this game. In his last five games he is batting .316 with two doubles, two home runs, a walk and six RBIs.
• Ryan O'Hearn paces his team with 41 hits and a .396 OBP. He has a batting average of .306 while slugging .507.
• His batting average is 13th among all qualified players, his on-base percentage is ninth, and he is 25th in slugging.
• Adley Rutschman has seven doubles, a triple, five home runs and 19 walks while hitting .213.
• Jackson Holliday is batting .268 with four doubles, two triples, six home runs and 10 walks.

Red Sox vs Orioles Head to Head

• 4/3/2025: 8-4 BOS (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/2/2025: 3-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 3/31/2025: 8-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/11/2024: 5-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/10/2024: 5-3 BAL (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/9/2024: 12-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/18/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/16/2024: 12-10 BOS (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/15/2024: 5-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/29/2024: 6-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)

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