Rays vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for March 26

Odds updated as of 12:12 a.m.

The Tampa Bay Rays and the St. Louis Cardinals meet for MLB Opening Day on Thursday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Rays vs Cardinals Game Info

• Tampa Bay Rays (0-0) vs. St. Louis Cardinals (0-0)
• Date: Thursday, March 26, 2026
• Time: 4:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: CARD and RAYS

Rays vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-124) | STL: (+106)
• Spread: TB: -1.5 (+146) | STL: +1.5 (-178)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Rays vs Cardinals Probable Starting Pitchers

Probable Pitchers: Drew Rasmussen (Rays) - 0-0, 0.00 ERA vs Matthew Liberatore (Cardinals) - 0-0, 0.00 ERA

The Rays will call on Drew Rasmussen against the Cardinals and Matthew Liberatore. Rasmussen and his team were 15-16-0 ATS in his 31 appearances with a spread last season. Rasmussen and his team won as favorites in 47.4% of his 19 appearances last season with a moneyline. Last season when Liberatore pitched his team went 14-15-0 against the spread. Liberatore's team went 9-4 in games he appeared in when they were the moneyline underdog a season ago.

Rays vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (52.6%)

Rays vs Cardinals Moneyline

• St. Louis is a +106 underdog on the moneyline, while Tampa Bay is a -124 favorite on the road.

Rays vs Cardinals Spread

• The Rays are 1.5-run road favorites on the runline against the Cardinals. The Rays are +146 to cover, and the Cardinals are -178.

Rays vs Cardinals Over/Under

• Rays versus Cardinals, on March 26, has an over/under of 7.5, with the over being -118 and the under -104.

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Rays vs Cardinals Betting Trends

• The Rays came away with 39 wins in the 72 contests they were listed as the favorites last season.
• Last season Tampa Bay came away with a win 29 times in 55 chances when named as a favorite of at least -124 or shorter on the moneyline.
• The Rays and their opponents hit the over in 69 of their 157 games with a total last season.
• The Cardinals were the moneyline underdog 90 times last season. They finished 43-47 in those games.
• St. Louis went 24-36 in games it played as a moneyline underdog with odds of +106 or longer (40%).
• The Cardinals played in 156 games with a set over/under last season, and combined with their opponents to go over the total 80 times (80-71-5).

Rays Player Leaders

• Junior Caminero finished last season with 159 hits while batting .264.
• Yandy Diaz slashed .300/.366/.482 and finished with an OPS of .848.
• Chandler Simpson ended his last campaign with 122 hits, an OBP of .326, plus a slugging percentage of .345.
• Cedric Mullins slashed .216/.299/.391 and finished with an OPS of .690.

Cardinals Player Leaders

• Alec Burleson put up an on-base percentage of .343, a slugging percentage of .459, and had 144 hits last season.
• Ivan Herrera hit .284 with 13 doubles, 19 home runs and 43 walks.
• Masyn Winn hit .253 with 27 doubles, nine home runs and 34 walks a season ago.
• Victor Scott II hit .216 with 15 doubles, a triple, five home runs and 42 walks.

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