Rays vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for March 26

Odds updated as of 4:11 p.m.

The Tampa Bay Rays and the St. Louis Cardinals meet for MLB Opening Day on Thursday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Rays vs Cardinals Game Info

• Tampa Bay Rays (0-0) vs. St. Louis Cardinals (0-0)
• Date: Thursday, March 26, 2026
• Time: 4:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Rays.TV

Rays vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-130) | STL: (+110)
• Spread: TB: -1.5 (+130) | STL: +1.5 (-156)
• Total: 8 -- Over: (-108) | Under: (-112)

Rays vs Cardinals Probable Starting Pitchers

Probable Pitchers: Drew Rasmussen (Rays) - 0-0, 0.00 ERA vs Matthew Liberatore (Cardinals) - 0-0, 0.00 ERA

The Rays will give the nod to Drew Rasmussen against the Cardinals and Matthew Liberatore. Rasmussen and his team were 15-16-0 ATS in games he pitched last year. Rasmussen and his team won 47.4% of the games he started as the moneyline favorite last season, with a record of 9-10. Last season Liberatore and his team went 14-15-0 against the spread when he pitched. Liberatore and his team had a 9-4 record in the 13 games he pitched when they were the moneyline underdog a season ago.

Rays vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (52.8%)

Rays vs Cardinals Moneyline

• Tampa Bay is the favorite, -130 on the moneyline, while St. Louis is a +110 underdog despite being at home.

Rays vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Rays. The Cardinals are -156 to cover, and the Rays are +130.

Rays vs Cardinals Over/Under

• Rays versus Cardinals, on March 26, has an over/under of 8, with the over being -108 and the under -112.

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Rays vs Cardinals Betting Trends

• The Rays came away with 39 wins in the 72 contests they were listed as the favorites last season.
• Last season Tampa Bay came away with a win 24 times in 47 chances when named as a favorite of at least -130 or shorter on the moneyline.
• The Rays and their opponents hit the over in 69 of their 157 games with a total last season.
• The Cardinals put together a 43-47 record in games last season when they were the underdog on the moneyline (winning 47.8% of those games).
• St. Louis went 22-36 when playing as a moneyline underdog with odds of +110 or longer (37.9%).
• The Cardinals played in 156 games with an over/under set last season, and combined with their opponents to go over the total 80 times (80-71-5).

Rays Player Leaders

• Last season, Junior Caminero had 159 base hits, batting .264 with 73 extra-base hits.
• Yandy Diaz slashed .300/.366/.482 and finished with an OPS of .848.
• Last season, Chandler Simpson finished with no home runs, but 26 RBI and a batting average of .295 last season.
• Cedric Mullins slashed .216/.299/.391 and finished with an OPS of .690.

Cardinals Player Leaders

• Alec Burleson had an OBP of .343 and a slugging percentage of .459 while racking up 144 hits last season.
• Ivan Herrera hit .284 with 13 doubles, 19 home runs and 43 walks.
• Masyn Winn hit .253 with 27 doubles, nine home runs and 34 walks a season ago.
• Victor Scott II hit .216 with 15 doubles, a triple, five home runs and 42 walks.

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