Pirates vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 6

Odds updated as of 6:12 p.m.

In MLB action on Monday, the Pittsburgh Pirates take on the San Diego Padres.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Padres Game Info

• Pittsburgh Pirates (6-3) vs. San Diego Padres (4-5)
• Date: Monday, April 6, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Padres.TV

Pirates vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-134) | SD: (+114)
• Spread: PIT: -1.5 (+158) | SD: +1.5 (-192)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Pirates vs Padres Probable Starting Pitchers

Probable Pitchers: Bubba Chandler (Pirates) - 0-0, 0.00 ERA vs German Marquez (Padres) - 0-1, 12.00 ERA

The Pirates will give the ball to Bubba Chandler and the Padres will counter with German Marquez (0-1, 12.00 ERA). Chandler helped his team cover the spread in his only opportunity this season as a starter. Chandler's team won his only start as a favorite this season. Marquez has started just one game with a set spread, which the Padres failed to cover. The Padres were named the moneyline underdog for one Marquez start this season -- they lost.

Pirates vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (52.6%)

Pirates vs Padres Moneyline

• The Pirates vs Padres moneyline has Pittsburgh as a -134 favorite, while San Diego is a +114 underdog on the road.

Pirates vs Padres Spread

• The Padres are at +1.5 on the runline against the Pirates. The Padres are -192 to cover the spread, and the Pirates are +158.

Pirates vs Padres Over/Under

• Pirates versus Padres, on April 6, has an over/under of 8.5, with the over being -110 and the under -110.

Bet on Pittsburgh Pirates vs. San Diego Padres on FanDuel today!

Pirates vs Padres Betting Trends

• The Pirates have been listed as the favorite four times this season and have come away with a win in all of those games.
• Pittsburgh has played as a favorite of -134 or more just one time this year and came away with a win in that game.
• The Pirates and their opponents have gone over in five of their nine games with a total set by sportsbooks this season.
• The Pirates are 6-3-0 against the spread in their nine games that had a posted line this season.
• The Padres have a 2-3 record in games they were listed as the moneyline underdog (winning 40% of those games).
• In games it has played as a moneyline underdog with odds of +114 or longer, San Diego has a 2-1 record (winning 66.7% of its games).
• The Padres have played in nine games with an over/under set, and have combined with their opponents to go over the total three times (3-5-1).
• The Padres have covered 55.6% of their games this season, going 5-4-0 against the spread.

Pirates Player Leaders

• Ryan O'Hearn leads Pittsburgh with 11 hits and an OBP of .459, plus a team-best slugging percentage of .700. He's batting .367.
• Among all qualified hitters, he is 12th in batting average, his on-base percentage ranks 11th, and he is eighth in slugging.
• O'Hearn will look for his third straight game with a hit in this matchup. In his last five games he is hitting .313 with a double, two home runs, five walks and eight RBIs.
• Oneil Cruz leads Pittsburgh in slugging percentage (.657) thanks to four extra-base hits. He's batting .314 with an on-base percentage of .368.
• He ranks 29th in batting average, 53rd in on-base percentage and 11th in slugging among qualified hitters.
• Cruz has picked up at least one hit in five straight games. In his last five games he is hitting .429 with four home runs, a walk and 10 RBIs.
• Brandon Lowe is batting .267 with a .633 slugging percentage and four RBI this year.
• Bryan Reynolds has been key for Pittsburgh with eight hits, an OBP of .310 plus a slugging percentage of .417.

Padres Player Leaders

• Jackson Merrill has put up a slugging percentage of .469, a team-best for the Padres. He's batting .250 with an on-base percentage of .294.
• Including all the qualified hitters in the big leagues, his batting average is 76th, his on-base percentage ranks 127th, and he is 58th in slugging.
• Manny Machado has a .417 on-base percentage to pace his team. He has a batting average of .222 while slugging .407.
• Including all qualifying hitters, his batting average places him 111th, his on-base percentage ranks 24th, and he is 82nd in slugging.
• Ramon Laureano has accumulated a slugging percentage of .484 and has eight hits, both team-best figures for the Padres.
• Fernando Tatis Jr. is hitting .212 with three doubles and five walks.

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