Padres vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 25

Odds updated as of 9:12 p.m.

In MLB action on Tuesday, the San Diego Padres face the Pittsburgh Pirates.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Padres vs Pirates Game Info

• San Diego Padres (71-61) vs. Pittsburgh Pirates (64-69)
• Date: Tuesday, August 25, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and SportsNet PT

Padres vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-126) | PIT: (+108)
• Spread: SD: -1.5 (+172) | PIT: +1.5 (-210)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Padres vs Pirates Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 8-9, 3.38 ERA vs Paul Skenes (Pirates) - 9-11, 3.95 ERA

The Padres will give the nod to Michael King (8-9, 3.38 ERA), who is eyeing win No. 9 on the season, and the Pirates will turn to Paul Skenes (9-11, 3.95 ERA). When King starts, his team is 9-17-0 against the spread this season. King's team has a record of 7-9 this season when he starts and they are the favorite on the moneyline. The Pirates have an 8-18-0 record against the spread in Skenes' starts. The Pirates are 1-3 in Skenes' four starts this season that they were the moneyline underdog.

Padres vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (55.8%)

Padres vs Pirates Moneyline

• Pittsburgh is the underdog, +108 on the moneyline, while San Diego is a -126 favorite at home.

Padres vs Pirates Spread

• The Padres are 1.5-run home favorites on the runline against the Pirates. The Padres are +172 to cover, and the Pirates are -210.

Padres vs Pirates Over/Under

• Padres versus Pirates on Aug. 25 has an over/under of 8.5 runs, with the odds on the over -110 and the under set at -110.

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Padres vs Pirates Betting Trends

• The Padres have come away with 33 wins in the 58 contests they have been listed as the favorites in this season.
• This season San Diego has been victorious 20 times in 35 chances when named as a favorite of at least -126 on the moneyline.
• The Padres and their opponents have gone over the total this season in 58 of their 132 opportunities.
• The Padres have posted a record of 77-55-0 against the spread this season.
• The Pirates have been the underdog on the moneyline 61 total times this season. They've finished 25-36 in those games.
• When playing as a moneyline underdog with odds of +108 or longer, Pittsburgh has a 14-23 record (winning only 37.8% of its games).
• The Pirates have played in 131 games with an over/under set, and have combined with their opponents to go over the total 72 times (72-56-3).
• The Pirates have covered 48.9% of their games this season, going 64-67-0 ATS.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.358), slugging percentage (.449) and total hits (146) this season. He has a .287 batting average.
• Among qualified hitters in the majors, he is 17th in batting average, 33rd in on-base percentage, and 47th in slugging.
• Manny Machado is hitting .215 with 20 doubles, 24 home runs and 63 walks, while slugging .407 with an on-base percentage of .304.
• He is 130th in batting average, 111th in on-base percentage and 86th in slugging among qualifying hitters.
• Jackson Merrill has 119 hits this season and has a slash line of .238/.288/.412.
• Xander Bogaerts is batting .218 with a .319 OBP and 47 RBI for San Diego this season.

Pirates Player Leaders

• Bryan Reynolds a has .370 on-base percentage to lead the Pirates. He's batting .261 while slugging .424.
• He is 62nd in batting average, 17th in on-base percentage and 69th in slugging percentage among all qualifying hitters in the big leagues.
• Brandon Lowe's 123 hits lead his team. He has a batting average of .252 while slugging .475 with an on-base percentage of .317.
• Including all qualified players, he is 76th in batting average, 93rd in on-base percentage and 30th in slugging percentage.
• Nick Gonzales has put up a team-best .397 slugging percentage.
• Spencer Horwitz is batting .252 with 12 doubles, a triple, 10 home runs and 45 walks.

Padres vs Pirates Head to Head

• 8/24/2026: 3-2 PIT (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: +102)
• 4/8/2026: 8-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2026: 7-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 6, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/6/2026: 5-0 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 5-0 PIT (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/30/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/4/2025: 4-0 SD (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/2/2025: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 8-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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