Padres vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 31

Odds updated as of 1:12 p.m.

Sunday's slate in the MLB includes a matchup between the San Diego Padres and the Washington Nationals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Nationals Game Info

• San Diego Padres (32-25) vs. Washington Nationals (30-29)
• Date: Sunday, May 31, 2026
• Time: 1:35 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and Padres.TV

Padres vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-116) | WSH: (-102)
• Spread: SD: -1.5 (+142) | WSH: +1.5 (-172)
• Total: 9.5 -- Over: (+100) | Under: (-122)

Padres vs Nationals Probable Starting Pitchers

Probable Pitchers: Griffin Canning (Padres) - 0-3, 7.54 ERA vs Zack Littell (Nationals) - 4-4, 5.23 ERA

This contest's pitching matchup is set, as the Padres will send Griffin Canning (0-3) to the mound, while Zack Littell (4-4) will take the ball for the Nationals. Canning and his team are 1-4-0 ATS this season when he starts. Canning's team is 1-1 this season when he starts and they're favored on the moneyline. The Nationals have a 4-3-0 ATS record in Littell's seven starts with a set spread. The Nationals have been the moneyline underdog in seven of Littell's starts this season, and they went 4-3 in those games.

Padres vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56%)

Padres vs Nationals Moneyline

• Washington is the underdog, -102 on the moneyline, while San Diego is a -116 favorite despite being on the road.

Padres vs Nationals Spread

• The Nationals are +1.5 on the run line against the Padres. The Nationals are -172 to cover, and the Padres are +142.

Padres vs Nationals Over/Under

• Padres versus Nationals on May 31 has an over/under of 9.5 runs, with the odds on the over +100 and the under set at -122.

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Padres vs Nationals Betting Trends

• The Padres have been victorious in 15, or 53.6%, of the 28 contests they have been chosen as favorites in this season.
• This year San Diego has won 15 of 26 games when listed as at least -116 on the moneyline.
• The Padres and their opponents have hit the over in 24 of their 57 games with a total set by oddsmakers this season.
• In 57 games with a line this season, the Padres have a mark of 32-25-0 against the spread.
• The Nationals have won 28 of the 55 games they were listed as the moneyline underdog this season (50.9%).
• Washington is 27-24 (winning 52.9% of its games) when playing as a moneyline underdog of -102 or longer.
• In the 59 games bookmakers have set an over/under for the Nationals, they have combined with opponents to go over the total 37 times (37-19-3).
• The Nationals have put together a 37-22-0 record ATS this season (covering 62.7% of the time).

Padres Player Leaders

• Xander Bogaerts has three doubles, eight home runs and 20 walks while batting .241. He has an on-base percentage of .308 and a slugging percentage of .377.
• Among the qualified hitters in MLB, his batting average ranks 95th, his on-base percentage ranks 116th, and he is 111th in slugging.
• Gavin Sheets leads San Diego in total hits (40) this season while batting .252 with 19 extra-base hits. He's slugging .484 with an on-base percentage of .343.
• Among qualifying batters, he ranks 81st in batting average, 62nd in on-base percentage and 32nd in slugging percentage.
• Manny Machado has 35 hits this season and has a slash line of .178/.272/.360.
• Machado has picked up a hit in two straight games. During his last five outings he is batting .211 with a double, two home runs, two walks and five RBIs.
• Fernando Tatis Jr. leads the Padres with an OPS of .670. He has a slash line of .271/.346/.324 this season.
• Tatis enters this matchup on a six-game hitting streak. During his last 10 outings he is batting .447 with a double, a home run, five walks and three RBIs.

Nationals Player Leaders

• James Wood has racked up a team-best OBP (.410) and slugging percentage (.538), while leading the Nationals in hits (61, while batting .271).
• Including all the qualified hitters in MLB, he is 47th in batting average, fourth in on-base percentage and 11th in slugging percentage.
• C.J. Abrams' 61 hits and .538 slugging percentage are both team-highs. He has a batting average of .290 with an on-base percentage of .390.
• He ranks 22nd in batting average, 16th in on-base percentage and 11th in slugging percentage in the majors.
• Daylen Lile is batting .253 with 15 doubles, a triple, seven home runs and 19 walks.
• Curtis Mead has nine doubles, eight home runs and 22 walks while hitting .250.

Padres vs Nationals Head to Head

• 5/30/2026: 9-4 WSH (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/29/2026: 7-5 SD (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/18/2025: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/25/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/24/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/23/2025: 10-6 WSH (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/25/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/24/2024: 12-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/23/2024: 4-0 SD (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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