Padres vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 16

Odds updated as of 1:12 p.m.

In MLB action on Sunday, the San Diego Padres take on the Cleveland Guardians.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Guardians Game Info

• San Diego Padres (66-58) vs. Cleveland Guardians (60-64)
• Date: Sunday, August 16, 2026
• Time: 1:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Padres.TV

Padres vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-110) | CLE: (+100)
• Spread: SD: -1.5 (+146) | CLE: +1.5 (-178)
• Total: 8.5 -- Over: (+102) | Under: (-124)

Padres vs Guardians Probable Starting Pitchers

Probable Pitchers: Casey Mize (Padres) - 4-7, 3.38 ERA vs Tanner Bibee (Guardians) - 4-12, 3.99 ERA

The Padres will give the ball to Casey Mize (4-7, 3.38 ERA), who is eyeing win No. 5 on the season, and the Guardians will counter with Tanner Bibee (4-12, 3.99 ERA). Mize's team is 9-9-0 against the spread in his starts this season. When Mize starts a game and his team is the favorite on the moneyline, they have a record of 4-5. The Guardians have gone 6-17-0 ATS in Bibee's 23 starts with a set spread. The Guardians are 4-7 in Bibee's 11 starts this season that they were the moneyline underdog.

Padres vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.3%)

Padres vs Guardians Moneyline

• Looking at the moneyline for Padres-Guardians, San Diego is the favorite at -110, and Cleveland is +100 playing at home.

Padres vs Guardians Spread

• The Padres are 1.5-run road favorites on the runline against the Guardians. The Padres are +146 to cover, and the Guardians are -178.

Padres vs Guardians Over/Under

• Padres versus Guardians on Aug. 16 has an over/under of 8.5 runs, with the odds on the over +102 and the under set at -124.

Bet on San Diego Padres vs. Cleveland Guardians on FanDuel today!

Padres vs Guardians Betting Trends

• The Padres have been victorious in 28, or 54.9%, of the 51 contests they have been chosen as favorites in this season.
• This season San Diego has been victorious 28 times in 51 chances when named as a favorite of at least -110 on the moneyline.
• The Padres' games have gone over the total in 56 of their 124 opportunities.
• The Padres have an against the spread record of 70-54-0 in 124 games with a line this season.
• The Guardians are 26-24 in games they were listed as the moneyline underdog (winning 52% of those games).
• Cleveland has a record of 23-22 when playing as a moneyline underdog with odds of +100 or longer (51.1%).
• The Guardians have played in 118 games with an over/under set, and have combined with their opponents to go over the total 58 times (58-60-0).
• The Guardians have a 56-62-0 record ATS this season (covering 47.5% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 132 hits and an OBP of .354, plus a team-best slugging percentage of .423. He's batting .279.
• He ranks 27th in batting average, 42nd in on-base percentage, and 73rd in slugging among qualified hitters in the majors.
• Manny Machado has 20 doubles, 23 home runs and 55 walks. He's batting .213 and slugging .410 with an on-base percentage of .294.
• Among qualifying batters, his batting average places him 134th, his on-base percentage 129th, and his slugging percentage 91st.
• Jackson Merrill is batting .244 with a .417 slugging percentage and 63 RBI this year.
• Xander Bogaerts has 11 home runs, 45 RBI and a batting average of .221 this season.

Guardians Player Leaders

• Chase DeLauter has accumulated a slugging percentage of .443 and has 115 hits, both team-best numbers for the Guardians. He's batting .286 and with an on-base percentage of .358.
• He ranks 17th in batting average, 35th in on-base percentage and 58th in slugging percentage among all qualifying hitters in MLB.
• DeLauter takes a five-game hitting streak into this game. During his last five outings he is batting .435 with a double, a home run and an RBI.
• Jose Ramirez is batting .232 with 19 doubles, 10 home runs and 53 walks. He's slugging .380 with an on-base percentage of .337.
• He ranks 115th in batting average, 62nd in on-base percentage and 115th in slugging percentage in the majors.
• Brayan Rocchio is batting .254 with 18 doubles, two triples, 10 home runs and 31 walks.
• Steven Kwan's .369 OBP paces his team.

Padres vs Guardians Head to Head

• 8/15/2026: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: +102)
• 8/14/2026: 7-5 SD (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: +106)
• 4/2/2025: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/1/2025: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 3/31/2025: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/21/2024: 2-1 SD (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/20/2024: 7-0 SD (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/19/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2023: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/13/2023: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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