Orioles vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 6:12 p.m.

The Baltimore Orioles will face the Washington Nationals in MLB action on Friday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Nationals Game Info

• Baltimore Orioles (15-27) vs. Washington Nationals (18-27)
• Date: Friday, May 16, 2025
• Time: 7:05 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and MASN2

Orioles vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-122) | WSH: (+104)
• Spread: BAL: +1.5 (-205) | WSH: -1.5 (+168)
• Total: 9 -- Over: (-100) | Under: (-122)

Orioles vs Nationals Probable Starting Pitchers

Probable Pitchers: Cade Povich (Orioles) - 1-3, 5.55 ERA vs MacKenzie Gore (Nationals) - 2-4, 3.59 ERA

This contest's pitching matchup is set, as the Orioles will send Cade Povich (1-3) to the mound, while MacKenzie Gore (2-4) will take the ball for the Nationals. Povich and his team are 1-6-0 ATS this season when he starts. Povich's team has a record of 2-2 this season when he starts and they are the favorite on the moneyline. The Nationals have a 4-5-0 record against the spread in Gore's starts. The Nationals have been the underdog on the moneyline in three of Gore's starts this season, and they went 1-2 in those matchups.

Orioles vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (54.5%)

Orioles vs Nationals Moneyline

• Washington is a +104 underdog on the moneyline, while Baltimore is a -122 favorite at home.

Orioles vs Nationals Spread

• The Nationals are 1.5-run favorites against the spread for this matchup with the Orioles. The Nationals are +168 to cover, while the Orioles are -205 to cover as a 1.5-run underdog on the runline.

Orioles vs Nationals Over/Under

• An over/under of 9 has been set for Orioles-Nationals on May 16, with the over being -100 and the under -122.

Bet on Baltimore Orioles vs. Washington Nationals on FanDuel today!

Orioles vs Nationals Betting Trends

• The Orioles have been chosen as favorites in 24 games this year and have walked away with the win nine times (37.5%) in those games.
• This season Baltimore has come away with a win eight times in 19 chances when named as a favorite of at least -122 on the moneyline.
• The Orioles and their opponents have gone over the total this season in 20 of their 42 opportunities.
• The Orioles have an against the spread record of 13-29-0 in 42 games with a line this season.
• The Nationals have a 15-18 record in games they were the underdog on the moneyline (winning 45.5% of those games).
• In games it has played as a moneyline underdog with odds of +104 or longer, Washington has a 13-15 record (winning 46.4% of its games).
• In the 43 games bookmakers have set an over/under for the Nationals, they have combined with opponents to go over the total 21 times (21-21-1).
• The Nationals have put together a 22-21-0 record ATS this season (covering 51.2% of the time).

Orioles Player Leaders

• Cedric Mullins leads Baltimore in OBP (.335) this season, fueled by 33 hits. He has a .232 batting average and a slugging percentage of .451.
• Among all qualifying batters in the majors, his batting average ranks 118th, his on-base percentage ranks 74th, and he is 60th in slugging.
• Mullins has recorded a base hit in two games in a row. In his last five games he is batting .263 with two doubles, a home run and four RBIs.
• Ryan O'Hearn is hitting .295 with four doubles, seven home runs and 13 walks, while slugging .518 with an on-base percentage of .378.
• O'Hearn takes a two-game streak with at least one hit into this contest. During his last five outings he is hitting .235 with three walks.
• Gunnar Henderson has a team-high 38 hits to go with a slugging percentage of .479.
• Adley Rutschman is batting .200 with a .300 OBP and 11 RBI for Baltimore this season.

Nationals Player Leaders

• James Wood has a slugging percentage of .523, a team-high for the Nationals. He's batting .267 with an on-base percentage of .364.
• He ranks 62nd in batting average, 40th in on-base percentage and 20th in slugging percentage among all qualifying batters in the big leagues.
• C.J. Abrams has racked up 40 hits with a .379 OBP to lead his team in both. He has a batting average of .317 while slugging .548.
• His batting average is ninth among all qualified players, his on-base percentage is 26th, and he is 14th in slugging.
• Nathaniel Lowe has seven doubles, seven home runs and 18 walks while batting .226.
• Keibert Ruiz has six doubles, two home runs and eight walks while hitting .285.

Orioles vs Nationals Head to Head

• 4/24/2025: 2-1 BAL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/23/2025: 4-3 WSH (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/22/2025: 7-0 WSH (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/14/2024: 4-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/13/2024: 9-3 WSH (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/8/2024: 7-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/7/2024: 3-0 WSH (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 9/27/2023: 5-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 9/26/2023: 1-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 4/19/2023: 4-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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