Orioles vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 7:11 a.m.

On Friday in MLB, the Baltimore Orioles are up against the Washington Nationals.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Orioles vs Nationals Game Info

• Baltimore Orioles (15-27) vs. Washington Nationals (18-27)
• Date: Friday, May 16, 2025
• Time: 7:05 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and MASN2

Orioles vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-110) | WSH: (-106)
• Spread: BAL: +1.5 (-194) | WSH: -1.5 (+160)
• Total: 9 -- Over: (-110) | Under: (-110)

Orioles vs Nationals Probable Starting Pitchers

Probable Pitchers: Cade Povich (Orioles) - 1-3, 5.55 ERA vs MacKenzie Gore (Nationals) - 2-4, 3.59 ERA

The probable pitchers are Cade Povich (1-3) for the Orioles and MacKenzie Gore (2-4) for the Nationals. Povich's team is 1-6-0 against the spread in his starts this season. Povich's team has a record of 2-2 this season when he starts and they are the favorite on the moneyline. The Nationals have gone 4-5-0 against the spread when Gore starts. The Nationals have been the underdog on the moneyline in three of Gore's starts this season, and they went 1-2 in those matchups.

Orioles vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (52.4%)

Orioles vs Nationals Moneyline

• Looking at the moneyline for Nationals-Orioles, Washington is the underdog at -106, and Baltimore is -110 playing at home.

Orioles vs Nationals Spread

• The Nationals are 1.5-run favorites against the spread for this matchup with the Orioles. The Nationals are +160 to cover, while the Orioles are -194 to cover as a 1.5-run underdog on the runline.

Orioles vs Nationals Over/Under

• A combined run total of 9 has been set for Orioles-Nationals on May 16, with the over at -110 and the under at -110.

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Orioles vs Nationals Betting Trends

• The Orioles have come away with nine wins in the 24 contests they have been listed as the favorites in this season.
• This season Baltimore has been victorious nine times in 24 chances when named as a favorite of at least -110 on the moneyline.
• The Orioles and their opponents have gone over in 20 of their 42 games with a total set by sportsbooks this season.
• The Orioles are 13-29-0 against the spread in their 42 games that had a posted line this season.
• The Nationals have been the underdog on the moneyline 33 total times this season. They've gone 15-18 in those games.
• Washington has a 15-18 record (winning 45.5% of its games) when playing as a moneyline underdog of -106 or longer.
• The Nationals have combined with opponents to go over the total 21 times this season for a 21-21-1 record against the over/under.
• The Nationals have covered 51.2% of their games this season, going 22-21-0 ATS.

Orioles Player Leaders

• Cedric Mullins has 33 hits this season and a team-best OBP of .335. He has a .232 batting average and a slugging percentage of .451.
• Among all qualifying batters in the majors, his batting average ranks 116th, his on-base percentage ranks 74th, and he is 60th in slugging.
• Mullins has recorded at least one hit in two games in a row. During his last five outings he is hitting .263 with two doubles, a home run and four RBIs.
• Ryan O'Hearn has four doubles, seven home runs and 13 walks. He's batting .295 and slugging .518 with an on-base percentage of .378.
• O'Hearn takes a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .235 with three walks.
• Gunnar Henderson leads Baltimore in slugging percentage (.479) and total hits (38) this season.
• Adley Rutschman is batting .200 with a .300 OBP and 11 RBI for Baltimore this season.

Nationals Player Leaders

• James Wood has accumulated a slugging percentage of .523, a team-best for the Nationals. He's batting .267 with an on-base percentage of .364.
• Including all qualified hitters, he is 61st in batting average, while his on-base percentage is 40th and he is 20th in slugging.
• C.J. Abrams has racked up 40 hits with a .379 on-base percentage to pace his team in both. He has a batting average of .317 while slugging .548.
• Including all qualifying hitters, his batting average places him ninth, his on-base percentage ranks 26th, and he is 13th in slugging.
• Nathaniel Lowe has seven doubles, seven home runs and 18 walks while batting .226.
• Keibert Ruiz has six doubles, two home runs and eight walks while hitting .285.

Orioles vs Nationals Head to Head

• 4/24/2025: 2-1 BAL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/23/2025: 4-3 WSH (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/22/2025: 7-0 WSH (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/14/2024: 4-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/13/2024: 9-3 WSH (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/8/2024: 7-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/7/2024: 3-0 WSH (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 9/27/2023: 5-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 9/26/2023: 1-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 4/19/2023: 4-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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