NFL Games This Week: Predictions, Odds, Picks, Best Bets for Wild Card Round

The Wild Card NFL Playoffs lineup has plenty of excitement, including a matchup between the Buffalo Bills and the Jacksonville Jaguars.

For a breakdown of all the important matchups in the NFL this week, dive into our betting preview below.

Panthers vs. Rams

The NFC Wild Card round of the NFL Playoffs will see the Carolina Panthers (8-9) and Los Angeles Rams (12-5) hit the field at Bank of America Stadium on Jan. 10 at 4:30 p.m. ET.

• Game Preview: Los Angeles Rams at Carolina Panthers
• Projected Favorite: Rams (77.76% win probability)
• Spread: Los Angeles (-10.5)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 4:30 p.m. ET
• Channel: FOX

Bet on Carolina vs. Los Angeles with FanDuel Sportsbook.

Bears vs. Packers

A playoff matchup pits the Chicago Bears (11-6) against the Green Bay Packers (9-7-1) in the NFC Wild Card round on Jan. 10 at 8 p.m. ET at Soldier Field.

• Game Preview: Green Bay Packers at Chicago Bears
• Spread: Green Bay (-1.5)
• Total: 46.5 -- Over: (-106) | Under: (-114)
• Time: 8 p.m. ET
• Channel: Amazon Prime Video

Bet on Chicago vs. Green Bay with FanDuel Sportsbook.

Jaguars vs. Bills

The Buffalo Bills (12-5) and Jacksonville Jaguars (13-4) hit the field in the AFC Wild Card round of the NFL Playoffs at EverBank Stadium on Sunday, January 11, 2026.

• Game Preview: Buffalo Bills at Jacksonville Jaguars
• Projected Favorite: Jaguars (63.87% win probability)
• Spread: Jacksonville (-1.5)
• Total: 51.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. Buffalo with FanDuel Sportsbook.

Eagles vs. 49ers

The San Francisco 49ers (12-5) and Philadelphia Eagles (11-6) hit the field in the NFC Wild Card round of the NFL Playoffs at Lincoln Financial Field on Sunday, January 11, 2026.

• Game Preview: San Francisco 49ers at Philadelphia Eagles
• Projected Favorite: Eagles (65.56% win probability)
• Spread: Philadelphia (-5.5)
• Total: 44.5 -- Over: (-104) | Under: (-118)
• Time: 4:30 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. San Francisco with FanDuel Sportsbook.

Patriots vs. Chargers

The AFC Wild Card round of the NFL Playoffs will see the Los Angeles Chargers (11-6) and New England Patriots (14-3) meet at Gillette Stadium on Jan. 11 at 8:15 p.m. ET.

• Game Preview: Los Angeles Chargers at New England Patriots
• Projected Favorite: Patriots (71.89% win probability)
• Spread: New England (-3.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: NBC/Peacock

Bet on New England vs. Los Angeles with FanDuel Sportsbook.

Steelers vs. Texans

A playoff matchup pits the Pittsburgh Steelers (10-7) against the Houston Texans (12-5) in the AFC Wild Card round on Jan. 12 at 8:15 p.m. ET at Acrisure Stadium.

• Game Preview: Houston Texans at Pittsburgh Steelers
• Projected Favorite: Steelers (55.56% win probability)
• Spread: Houston (-3)
• Total: 38.5 -- Over: (-105) | Under: (-115)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Pittsburgh vs. Houston with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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