NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 4

There is no shortage of excitement on the Week 4 NFL schedule, including the Denver Broncos squaring off against the San Francisco 49ers.

Here is what you need to know in terms of the betting odds for Week 4 in the NFL.

Browns vs. Steelers

The Pittsburgh Steelers (2-1), who took down against the Bengals in their previous tilt, visit the Cleveland Browns (2-1) at Huntington Bank Field on Oct. 1 at 8:15 p.m. ET. The Browns grabbed a win against the Panthers in their last game.

• Game Preview: Pittsburgh Steelers at Cleveland Browns
• Projected Favorite: Steelers (53.43% win probability)
• Spread: Pittsburgh (-2.5)
• Total: 37.5 -- Over: (-112) | Under: (-108)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Cleveland vs. Pittsburgh with FanDuel Sportsbook.

Commanders vs. Colts

Jonathan Taylor, who ranks seventh-best in the league in rushing yards, will try to lead the charge for the Indianapolis Colts (1-2) on Oct. 4 at 9:30 a.m. ET, when they visit the Washington Commanders (1-2) and their third-best run defense (82.0 rushing yards allowed per game).

• Game Preview: Indianapolis Colts vs. Washington Commanders
• Projected Favorite: Colts (60.80% win probability)
• Spread: Indianapolis (-4.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Washington vs. Indianapolis with FanDuel Sportsbook.

Buccaneers vs. Packers

The Green Bay Packers (1-2) and the Tampa Bay Buccaneers (0-3), who both lost their last tilt, will match up at 1 p.m. ET on Sunday, Oct. 4. In their previous games, the Packers lost 35-14 to the Falcons, and the Buccaneers were defeated by the Vikings 23-16.

• Game Preview: Green Bay Packers at Tampa Bay Buccaneers
• Projected Favorite: Packers (58.98% win probability)
• Spread: Green Bay (-3)
• Total: 38.5 -- Over: (-114) | Under: (-106)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Green Bay with FanDuel Sportsbook.

Bills vs. Patriots

Dalton Kincaid, who ranks eighth-best in the NFL in receiving yards, will aim to lead the way for the Buffalo Bills (3-0) on Oct. 4 at 1 p.m. ET, when they host the New England Patriots (1-2) and their second-best pass defense (170.0 passing yards allowed per game).

• Game Preview: New England Patriots at Buffalo Bills
• Projected Favorite: Bills (74.36% win probability)
• Spread: Buffalo (-7)
• Total: 49.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Buffalo vs. New England with FanDuel Sportsbook.

Ravens vs. Titans

Derrick Henry will lead the Baltimore Ravens (2-1) into their battle against the Tennessee Titans (0-3) at M&T Bank Stadium on Sunday at 1 p.m. ET.

• Game Preview: Tennessee Titans at Baltimore Ravens
• Projected Favorite: Ravens (83.38% win probability)
• Spread: Baltimore (-11.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Tennessee with FanDuel Sportsbook.

Bears vs. Jets

A pair of the best offensive performers in football will be featured when running back D'Andre Swift and the Chicago Bears (2-1) host Garrett Wilson and the New York Jets (1-2) on Sunday, October 4, 2026.

• Game Preview: New York Jets at Chicago Bears
• Projected Favorite: Bears (70.21% win probability)
• Spread: Chicago (-3.5)
• Total: 43.5 -- Over: (-114) | Under: (-106)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. New York with FanDuel Sportsbook.

Giants vs. Cardinals

On Sunday, Oct. 4 at 1 p.m. ET, the Arizona Cardinals (1-2) will attempt to bounce back from their recent 36-30 loss to the 49ers when they go head to head against the New York Giants (2-1) at MetLife Stadium. The Giants won their previous contest 12-7 versus the Titans.

• Game Preview: Arizona Cardinals at New York Giants
• Projected Favorite: Cardinals (53.29% win probability)
• Spread: Arizona (-2.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Arizona with FanDuel Sportsbook.

Bengals vs. Jaguars

When the Cincinnati Bengals (2-1) and the Jacksonville Jaguars (2-1) square off on Sunday, Oct. 4 at 1 p.m. ET, the Bengals will be trying to bounce back from a loss to the Steelers, and the Jaguars will be looking to follow up their recent victory over the Patriots with another win.

• Game Preview: Jacksonville Jaguars at Cincinnati Bengals
• Projected Favorite: Jaguars (53.08% win probability)
• Spread: Cincinnati (-2.5)
• Total: 51.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. Jacksonville with FanDuel Sportsbook.

Eagles vs. Rams

After going down 30-26 to the Broncos in their last contest, the Los Angeles Rams (1-2) will visit the Philadelphia Eagles (2-1), who are coming off a 27-7 loss to the Bears, at Lincoln Financial Field. Kickoff is slated for 1 p.m. ET on Sunday, Oct. 4.

• Game Preview: Los Angeles Rams at Philadelphia Eagles
• Projected Favorite: Rams (56.25% win probability)
• Spread: Los Angeles (-3.5)
• Total: 42.5 -- Over: (-122) | Under: (+100)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Los Angeles with FanDuel Sportsbook.

Texans vs. Cowboys

The Houston Texans (0-3), who were defeated by the Colts in their previous tilt, host the Dallas Cowboys (1-2) at NRG Stadium on Oct. 4 at 1 p.m. ET. The Cowboys took the L against the Ravens in their last game.

• Game Preview: Dallas Cowboys at Houston Texans
• Projected Favorite: Texans (62.55% win probability)
• Spread: Houston (-3)
• Total: 48.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Houston vs. Dallas with FanDuel Sportsbook.

Vikings vs. Dolphins

The Miami Dolphins (0-3) and their 31st-ranked scoring offense (12.0 points per game) will need to play their best when they battle the Minnesota Vikings (3-0), who have the second-ranked scoring defense in the league (13.7 points allowed per game). The game is set for Sunday, Oct. 4 at 4:05 p.m. ET.

• Game Preview: Miami Dolphins at Minnesota Vikings
• Projected Favorite: Vikings (69.67% win probability)
• Spread: Minnesota (-9.5)
• Total: 38.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Minnesota vs. Miami with FanDuel Sportsbook.

49ers vs. Broncos

After securing a 36-30 win versus the Cardinals in their previous tilt, the San Francisco 49ers (3-0) will host the Denver Broncos (2-1), who are coming off a 30-26 win over the Rams, at Levi's Stadium. Kickoff is scheduled for 4:25 p.m. ET on Sunday, Oct. 4.

• Game Preview: Denver Broncos at San Francisco 49ers
• Projected Favorite: 49ers (65.20% win probability)
• Spread: San Francisco (-2.5)
• Total: 47.5 -- Over: (-114) | Under: (-106)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on San Francisco vs. Denver with FanDuel Sportsbook.

Raiders vs. Chiefs

The Kansas City Chiefs (3-0) are set to match up with the Las Vegas Raiders (3-0) at Allegiant Stadium on Sunday, Oct. 4 at 4:25 p.m. ET. Both squads won their previous tilt, as the Chiefs defeated the Dolphins 24-10, and the Raiders won 35-27 versus the Saints.

• Game Preview: Kansas City Chiefs at Las Vegas Raiders
• Projected Favorite: Chiefs (64.95% win probability)
• Spread: Kansas City (-4.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Kansas City with FanDuel Sportsbook.

Seahawks vs. Chargers

Jaxon Smith-Njigba and the Seattle Seahawks (2-1) face the Los Angeles Chargers (0-3) on Sunday at 4:25 p.m. ET, at Lumen Field.

• Game Preview: Los Angeles Chargers at Seattle Seahawks
• Projected Favorite: Seahawks (74.75% win probability)
• Spread: Seattle (-7)
• Total: 43.5 -- Over: (-102) | Under: (-120)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Seattle vs. Los Angeles with FanDuel Sportsbook.

Panthers vs. Lions

At Bank of America Stadium on Sunday, Jahmyr Gibbs and the Detroit Lions (2-1) face Bryce Young and the Carolina Panthers (1-2) in a battle featuring two of the biggest stars in football offensively, beginning at 8:20 p.m. ET.

• Game Preview: Detroit Lions at Carolina Panthers
• Projected Favorite: Lions (62.48% win probability)
• Spread: Detroit (-3.5)
• Total: 51.5 -- Over: (-108) | Under: (-112)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Carolina vs. Detroit with FanDuel Sportsbook.

Saints vs. Falcons

The New Orleans Saints (1-2) and Chris Olave, one of the NFL's top receivers, should have a productive day through the air on Monday, as the Atlanta Falcons (1-2) sport the 30th-ranked pass defense in the league. The two teams will square off at 8:15 p.m. ET on Oct. 5.

• Game Preview: Atlanta Falcons at New Orleans Saints
• Projected Favorite: Saints (55.84% win probability)
• Spread: New Orleans (-1.5)
• Total: 47.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: ESPN

Bet on New Orleans vs. Atlanta with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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