Penn State vs Northwestern Prediction, Odds, Picks, Best Bets for Week 5 2026

The Penn State Nittany Lions versus the Northwestern Wildcats is on the college football schedule for Friday.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Penn State vs Northwestern Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (-142) | Northwestern: (+118)
• Spread: Penn State: -2.5 (-118) | Northwestern: +2.5 (-104)
• Total: 45.5 -- Over: (-115) | Under: (-105)

Penn State vs Northwestern Betting Trends

• Penn State has won twice against the spread this season.
• Penn State has won twice ATS (2-2) as a 2.5-point or bigger favorite this season.
• Penn State has had two games (out of four) go over the total this year.
• Northwestern has beaten the spread three times in three games.
• Northwestern is unbeaten ATS (1-0) as a 2.5-point underdog or more this year.
• Two Northwestern games (of three) have gone over the point total this season.

Penn State vs Northwestern Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (60.8%)

Penn State vs Northwestern Point Spread

Northwestern is listed as an underdog by 2.5 points (-104 odds), and Penn State, the favorite, is -118 to cover.

Penn State vs Northwestern Over/Under

The Penn State-Northwestern matchup on Oct. 2 has been given an over/under of 45.5 points. The over is -115 and the under is -105.

Penn State vs Northwestern Moneyline

Northwestern is the underdog, +118 on the moneyline, while Penn State is a -142 favorite.

Penn State vs. Northwestern Points Insights

Penn State vs. Northwestern Game Info

• Game day: Friday, October 2, 2026
• Game time: 8 p.m. ET
• TV channel: FOX
• Location: Evanston, Illinois
• Stadium: Ryan Field

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Check out even more in-depth Penn State vs. Northwestern analysis on FanDuel Research.