Penn State vs Northwestern Prediction, Odds, Picks, Best Bets for Week 5 2026

The Penn State Nittany Lions versus the Northwestern Wildcats is on the college football schedule for Friday.

We've got you covered, in terms of the vital info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Penn State vs Northwestern Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (-140) | Northwestern: (+116)
• Spread: Penn State: -2.5 (-114) | Northwestern: +2.5 (-106)
• Total: 45.5 -- Over: (-110) | Under: (-110)

Penn State vs Northwestern Betting Trends

• Penn State has won twice against the spread this year.
• Penn State has won twice ATS (2-2) as a 2.5-point or bigger favorite this year.
• Two of four Penn State games have hit the over this year.
• Northwestern is 3-0-0 against the spread this season.
• Northwestern has yet to lose ATS (1-0) as a 2.5-point underdog or more this season.
• A pair of Northwestern three games in 2026 have hit the over.

Penn State vs Northwestern Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (60.5%)

Penn State vs Northwestern Point Spread

Northwestern is a 2.5-point underdog against Penn State. Northwestern is -106 to cover the spread, and Penn State is -114.

Penn State vs Northwestern Over/Under

The over/under for the Penn State versus Northwestern matchup on Oct. 2 has been set at 45.5, with -110 odds on the over and -110 odds on the under.

Penn State vs Northwestern Moneyline

Looking at the moneyline for Northwestern-Penn State, Northwestern is the underdog at +116, and Penn State is -140.

Penn State vs. Northwestern Points Insights

Penn State vs. Northwestern Game Info

• Game day: Friday, October 2, 2026
• Game time: 8 p.m. ET
• TV channel: FOX
• Location: Evanston, Illinois
• Stadium: Ryan Field

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Check out even more in-depth Penn State vs. Northwestern analysis on FanDuel Research.