Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for AL Wild Card Game 2 on Sept. 30

Odds updated as of 11:11 p.m.

The MLB schedule on Wednesday includes the Houston Astros taking on the Chicago White Sox for Game 2 of the AL Wild Card Series.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Astros vs White Sox Game Info

• Houston Astros (81-81) vs. Chicago White Sox (84-78)
• Date: Wednesday, September 30, 2026
• Time: 5 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: NBCSN and Peacock

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-144) | CHW: (+122)
• Spread: HOU: -1.5 (+158) | CHW: +1.5 (-192)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-4, 3.19 ERA vs Sean Burke (White Sox) - 11-7, 3.34 ERA

The probable starters are Hunter Brown (6-4, 3.19 ERA) for the Astros and Sean Burke (11-7, 3.34 ERA) for the White Sox. Brown's team is 9-11-0 against the spread in his starts this season. Brown's team has been victorious in 47.1% of the games he's started as the moneyline favorite with a record of 8-9. The White Sox have a 15-12-0 ATS record in Burke's 27 starts with a set spread. The White Sox have been the moneyline underdog in 15 of Burke's starts this season, and they went 6-9 in those games.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (59.2%)

Astros vs White Sox Moneyline

• Looking at the moneyline for White Sox-Astros, Chicago is the underdog at +122, and Houston is -144 playing at home.

Astros vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Astros. The White Sox are -192 to cover the spread, and the Astros are +158.

Astros vs White Sox Over/Under

• A combined run total of 7.5 has been set for Astros-White Sox on Sept. 30, with the over at -110 and the under at -110.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have come away with 38 wins in the 73 contests they have been listed as the favorites in this season.
• Houston has a record of 13-18 in contests when oddsmakers favor them by -144 or more on the moneyline.
• The Astros and their opponents have gone over in 81 of their 163 games with a total set by sportsbooks this season.
• The Astros have posted a record of 82-81-0 against the spread this season.
• The White Sox are 51-55 in games they were listed as the moneyline underdog (winning 48.1% of those games).
• When it has played as a moneyline underdog with odds of +122 or longer, Chicago has a 24-29 record (winning 45.3% of its games).
• In the 160 games bookmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 90 times (90-69-1).
• The White Sox have put together a 91-69-0 record against the spread this season.

Astros Player Leaders

• Yordan Alvarez has 179 hits and an OBP of .432 to go with a slugging percentage of .601. All three of those stats lead Houston hitters this season. He has a .316 batting average, as well.
• He ranks first in batting average, first in on-base percentage, and first in slugging among all qualifying hitters in baseball.
• Alvarez hopes to build on a 13-game hitting streak in this matchup. During his last 10 outings he is hitting .368 with three doubles, two home runs, six walks and seven RBIs.
• Isaac Paredes is batting .262 with 27 doubles, a triple, 25 home runs and 71 walks. He's slugging .447 with an on-base percentage of .360.
• He is 56th in batting average, 30th in on-base percentage and 49th in slugging among qualifying hitters.
• Christian Walker has collected 129 base hits, an OBP of .299 and a slugging percentage of .427 this season.
• Jeremy Pena is batting .277 with a .325 OBP and 56 RBI for Houston this season.
• Pena has safely hit in three straight games. During his last five outings he is batting .320 with two home runs and five RBIs.

White Sox Player Leaders

• Miguel Vargas has 31 doubles, a triple, 33 home runs and 101 walks while batting .250. He's slugging .474 with an on-base percentage of .363.
• Including all the qualifying hitters in the big leagues, he is 79th in batting average, 24th in on-base percentage and 30th in slugging percentage.
• Chase Meidroth leads his team with a .415 slugging percentage. He has a batting average of .276 with an on-base percentage of .350.
• His batting average ranks 33rd among all qualified players, his on-base percentage is 45th, and he is 80th in slugging.
• Sam Antonacci a has .370 on-base percentage to pace the White Sox.
• Munetaka Murakami's 94 hits lead his team.

Astros vs White Sox Head to Head

• 9/29/2026: 6-3 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/3/2026: 6-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/2/2026: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!