49ers vs Broncos Prediction, Odds, Picks, Best Bets for NFL Week 4

NFL action on Sunday includes the San Francisco 49ers playing the Denver Broncos.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NFL betting odds.

49ers vs Broncos Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction:

49ers vs Broncos Point Spread

The 49ers are 2.5-point favorites against the Broncos. The 49ers are -122 to cover the spread, while the Broncos are +100 to cover as a 2.5-point underdog.

49ers vs Broncos Over/Under

An over/under of 48.5 has been set for 49ers-Broncos on Oct. 4, with the over being -104 and the under -118.

49ers vs Broncos Moneyline

San Francisco is the favorite, -152 on the moneyline, while Denver is a +128 underdog on the road.

49ers vs Broncos Betting Trends

• San Francisco has won twice against the spread this season.
• The 49ers have one win ATS (1-1) as a 2.5-point favorite or greater this year.
• San Francisco has had two games (out of three) go over the total this year.
• The Broncos have won twice against the spread this year.
• Denver doesn't have a win ATS (0-1) as a 2.5-point underdog or greater this season.
• The Broncos have had one game (out of three) go over the total this year.

Check out even more in-depth 49ers vs. Broncos analysis on FanDuel Research.

49ers vs Broncos Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-152) | DEN: (+128)
• Spread: SF: -2.5 (-122) | DEN: +2.5 (100)
• Total: 48.5 -- Over: (-104) | Under: (-118)

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