49ers vs Broncos Prediction, Odds, Picks, Best Bets for NFL Week 4

The Sunday schedule in the NFL includes a matchup between the San Francisco 49ers and the Denver Broncos.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information about today's NFL betting odds.

49ers vs Broncos Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (65.2%)

49ers vs Broncos Point Spread

The 49ers are 2.5-point favorites against the Broncos. The 49ers are -115 to cover the spread, while the Broncos are -105 to cover as a 2.5-point underdog.

49ers vs Broncos Over/Under

The 49ers-Broncos matchup on Oct. 4 has been given an over/under of 46.5 points. The over is -110 and the under is -110.

49ers vs Broncos Moneyline

San Francisco is a -142 favorite on the moneyline, while Denver is a +120 underdog on the road.

49ers vs Broncos Betting Trends

• San Francisco has won twice against the spread this season.
• The 49ers have one win ATS (1-1) as a 2.5-point favorite or greater this year.
• Two of the 49ers' three games have gone over the point total.
• The Broncos have posted two wins against the spread this year.
• Denver doesn't have a win ATS (0-1) as a 2.5-point underdog or greater this year.
• One Broncos game (out of three) has gone over the point total this year.

Check out even more in-depth 49ers vs. Broncos analysis on FanDuel Research.

49ers vs Broncos Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-142) | DEN: (+120)
• Spread: SF: -2.5 (-115) | DEN: +2.5 (-105)
• Total: 46.5 -- Over: (-110) | Under: (-110)

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