Bills vs Patriots Prediction, Odds, Picks, Best Bets for NFL Week 4

The Buffalo Bills will face the New England Patriots in NFL action on Sunday.

All the information you need is below, in order to make a smart bet on this game at FanDuel Sportsbook.

Bills vs Patriots Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (74.4%)

Bills vs Patriots Point Spread

The Bills are 6.5-point favorites against the Patriots. The Bills are -122 to cover the spread, while the Patriots are +100 to cover as a 6.5-point underdog.

Bills vs Patriots Over/Under

The over/under for the Bills versus Patriots game on Oct. 4 has been set at 49.5, with -110 odds on the over and -110 odds on the under.

Bills vs Patriots Moneyline

The Bills vs Patriots moneyline has the Bills as a -340 favorite, while the Patriots are a +275 underdog on the road.

Bills vs Patriots Betting Trends

• Buffalo hasn't lost a game against the spread this year.
• The Bills have yet to lose ATS (1-0) as a 6.5-point favorite or greater this year.
• Two of the Bills' three games have gone over the point total.
• The Patriots have posted two wins against the spread this year.
• No Patriots game has gone over the point total this year.

Check out even more in-depth Bills vs. Patriots analysis on FanDuel Research.

Bills vs Patriots Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-340) | NE: (+275)
• Spread: BUF: -6.5 (-122) | NE: +6.5 (100)
• Total: 49.5 -- Over: (-110) | Under: (-110)

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