NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 3

The Week 3 NFL slate should have plenty of excitement on the field. Among those contests is the New England Patriots taking on the Jacksonville Jaguars.

To pick up an edge prior to Week 3 in the NFL, check out our betting preview below.

Packers vs. Falcons

Christian Watson and the Green Bay Packers (1-1) will host Bijan Robinson and the Atlanta Falcons (0-2) on Thursday at 8:15 p.m. ET, in a matchup between two of the biggest stars in football offensively.

• Game Preview: Atlanta Falcons at Green Bay Packers
• Projected Favorite: Packers (66.18% win probability)
• Spread: Green Bay (-4.5)
• Total: 43.5 -- Over: (-104) | Under: (-118)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Green Bay vs. Atlanta with FanDuel Sportsbook.

Commanders vs. Seahawks

The Seattle Seahawks (2-0) are scheduled to square off against the Washington Commanders (0-2) at Northwest Stadium on Sunday, Sept. 27 at 1 p.m. ET. In their last contests, the Seahawks defeated the Cardinals 31-7, and the Commanders lost 37-20 to the Cowboys.

• Game Preview: Seattle Seahawks at Washington Commanders
• Projected Favorite: Seahawks (70.90% win probability)
• Spread: Seattle (-8.5)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. Seattle with FanDuel Sportsbook.

Steelers vs. Bengals

The Cincinnati Bengals (2-0) are slated to match up with the Pittsburgh Steelers (1-1) at Acrisure Stadium on Sunday, Sept. 27 at 1 p.m. ET. In their last games, the Bengals took down the Texans 20-6, and the Steelers lost 20-3 to the Patriots.

• Game Preview: Cincinnati Bengals at Pittsburgh Steelers
• Projected Favorite: Bengals (51.00% win probability)
• Spread: Cincinnati (-3.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Pittsburgh vs. Cincinnati with FanDuel Sportsbook.

Colts vs. Texans

The Houston Texans (0-2) are scheduled to match up with the Indianapolis Colts (0-2) at Lucas Oil Stadium on Sunday, Sept. 27 at 1 p.m. ET. Both teams lost their last contest, as the Texans were defeated by the Bengals 20-6, and the Colts lost 33-30 to the Chiefs.

• Game Preview: Houston Texans at Indianapolis Colts
• Projected Favorite: Colts (55.85% win probability)
• Spread: Houston (-1.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Houston with FanDuel Sportsbook.

Dolphins vs. Chiefs

Star running back Kenneth Walker III and the Kansas City Chiefs (2-0) play the Miami Dolphins (0-2) on Sunday at 1 p.m. ET at Hard Rock Stadium.

• Game Preview: Kansas City Chiefs at Miami Dolphins
• Projected Favorite: Chiefs (70.23% win probability)
• Spread: Kansas City (-9.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Miami vs. Kansas City with FanDuel Sportsbook.

Bills vs. Chargers

The Buffalo Bills (2-0), who took down the Lions in their previous game, host the Los Angeles Chargers (0-2) at New Highmark Stadium on Sept. 27 at 1 p.m. ET. The Chargers were defeated by the Raiders in their last game.

• Game Preview: Los Angeles Chargers at Buffalo Bills
• Projected Favorite: Bills (77.34% win probability)
• Spread: Buffalo (-7.5)
• Total: 50.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Buffalo vs. Los Angeles with FanDuel Sportsbook.

Giants vs. Titans

The New York Giants (1-1) are slated to match up with the Tennessee Titans (0-2) at MetLife Stadium on Sunday, Sept. 27 at 1 p.m. ET. Both squads lost their last game, as the Giants were defeated by the Rams 28-6, and the Titans lost 24-20 to the Eagles.

• Game Preview: Tennessee Titans at New York Giants
• Projected Favorite: Giants (66.24% win probability)
• Spread: New York (-2.5)
• Total: 37.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Tennessee with FanDuel Sportsbook.

Lions vs. Jets

The Detroit Lions (1-1) are scheduled to match up with the New York Jets (1-1) at Ford Field on Sunday, Sept. 27 at 1 p.m. ET. Both squads lost their previous tilt, as the Lions were taken down by the Bills 41-31, and the Jets lost 20-17 to the Packers.

• Game Preview: New York Jets at Detroit Lions
• Projected Favorite: Lions (84.49% win probability)
• Spread: Detroit (-6.5)
• Total: 48.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. New York with FanDuel Sportsbook.

Browns vs. Panthers

The Carolina Panthers (1-1) are slated to collide with the Cleveland Browns (1-1) at Huntington Bank Field on Sunday, Sept. 27 at 1 p.m. ET. Both teams won their previous tilt, as the Panthers defeated the Falcons 34-3, and the Browns won 23-19 versus the Buccaneers.

• Game Preview: Carolina Panthers at Cleveland Browns
• Projected Favorite: Panthers (54.38% win probability)
• Spread: Carolina (-2.5)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Carolina with FanDuel Sportsbook.

Jaguars vs. Patriots

EverBank Stadium is the venue where the Jacksonville Jaguars (1-1) will take on the New England Patriots (1-1) on Sunday, September 27, 2026.

• Game Preview: New England Patriots at Jacksonville Jaguars
• Projected Favorite: Jaguars (60.40% win probability)
• Spread: Jacksonville (-2.5)
• Total: 45.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. New England with FanDuel Sportsbook.

49ers vs. Cardinals

At Levi's Stadium on Sunday, Brock Purdy and the San Francisco 49ers (2-0) play Trey McBride and the Arizona Cardinals (1-1) in a battle featuring two of the brightest stars in football, starting at 4:05 p.m. ET.

• Game Preview: Arizona Cardinals at San Francisco 49ers
• Projected Favorite: 49ers (80.80% win probability)
• Spread: San Francisco (-7.5)
• Total: 47.5 -- Over: (-118) | Under: (-104)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Arizona with FanDuel Sportsbook.

Buccaneers vs. Vikings

One of the best pass-catchers in football will be on show when Justin Jefferson and the Minnesota Vikings (2-0) visit the Tampa Bay Buccaneers (0-2) on Sunday, September 27, 2026.

• Game Preview: Minnesota Vikings at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (52.07% win probability)
• Spread: Minnesota (-1.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Minnesota with FanDuel Sportsbook.

Saints vs. Raiders

The New Orleans Saints (1-1) and the Las Vegas Raiders (2-0), who both won their last game, will go head to head at 4:25 p.m. ET on Sunday, Sept. 27. In their previous games, the Saints won 24-17 against the Ravens, and the Raiders defeated the Chargers 26-14.

• Game Preview: Las Vegas Raiders at New Orleans Saints
• Projected Favorite: Saints (72.97% win probability)
• Spread: New Orleans (-3)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on New Orleans vs. Las Vegas with FanDuel Sportsbook.

Cowboys vs. Ravens

A pair of the top offensive players in football will be featured when running back Derrick Henry and the Baltimore Ravens (1-1) take on QB Dak Prescott and the Dallas Cowboys (1-1) on Sunday, September 27, 2026.

• Game Preview: Baltimore Ravens vs. Dallas Cowboys
• Projected Favorite: Ravens (59.54% win probability)
• Spread: Baltimore (-3.5)
• Total: 52.5 -- Over: (-114) | Under: (-106)
• Time: 4:25 p.m. ET
• Channel: CBS/Paramount+

Bet on Dallas vs. Baltimore with FanDuel Sportsbook.

Broncos vs. Rams

The Los Angeles Rams (1-1) are set to do battle against the Denver Broncos (1-1) at Empower Field at Mile High on Sunday, Sept. 27 at 8:20 p.m. ET. Both squads won their previous game, as the Rams took down the Giants 28-6, and the Broncos won 20-13 versus the Jaguars.

• Game Preview: Los Angeles Rams at Denver Broncos
• Projected Favorite: Rams (50.85% win probability)
• Spread: Los Angeles (-1.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Denver vs. Los Angeles with FanDuel Sportsbook.

Bears vs. Eagles

The Philadelphia Eagles (2-0) are scheduled to collide with the Chicago Bears (1-1) at Soldier Field on Monday, Sept. 28 at 8:15 p.m. ET. In their previous contests, the Eagles took down the Titans 24-20, and the Bears lost 9-3 to the Vikings.

• Game Preview: Philadelphia Eagles at Chicago Bears
• Projected Favorite: Bears (52.73% win probability)
• Spread: Philadelphia (-3.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Chicago vs. Philadelphia with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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