NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 3

The NFL slate in Week 3, which includes the New England Patriots versus the Jacksonville Jaguars, should provide some fireworks.

Here's what you need to know in terms of the betting odds for Week 3 in the NFL.

Packers vs. Falcons

At Lambeau Field on Thursday, Christian Watson and the Green Bay Packers (1-1) play Bijan Robinson and the Atlanta Falcons (0-2) in a battle featuring a pair of the brightest stars in football, starting at 8:15 p.m. ET.

• Game Preview: Atlanta Falcons at Green Bay Packers
• Projected Favorite: Packers (67.70% win probability)
• Spread: Green Bay (-6.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Green Bay vs. Atlanta with FanDuel Sportsbook.

Steelers vs. Bengals

The Cincinnati Bengals (2-0) play on Sunday at 1 p.m. ET against the Pittsburgh Steelers (1-1) at Acrisure Stadium.

• Game Preview: Cincinnati Bengals at Pittsburgh Steelers
• Projected Favorite: Bengals (51.00% win probability)
• Spread: Cincinnati (-3.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Pittsburgh vs. Cincinnati with FanDuel Sportsbook.

Colts vs. Texans

The Houston Texans (0-2) and the Indianapolis Colts (0-2), who both lost their last tilt, will go head to head at 1 p.m. ET on Sunday, Sept. 27. In their previous games, the Texans lost 20-6 to the Bengals, and the Colts were defeated by the Chiefs 33-30.

• Game Preview: Houston Texans at Indianapolis Colts
• Projected Favorite: Colts (51.01% win probability)
• Spread: Houston (-2.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Houston with FanDuel Sportsbook.

Dolphins vs. Chiefs

Travis Kelce and the Kansas City Chiefs (2-0) meet the Miami Dolphins (0-2) on Sunday at 1 p.m. ET, at Hard Rock Stadium.

• Game Preview: Kansas City Chiefs at Miami Dolphins
• Projected Favorite: Chiefs (70.15% win probability)
• Spread: Kansas City (-10.5)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Miami vs. Kansas City with FanDuel Sportsbook.

Bills vs. Chargers

Star QB Josh Allen and the Buffalo Bills (2-0) meet the Los Angeles Chargers (0-2) on Sunday at 1 p.m. ET at New Highmark Stadium.

• Game Preview: Los Angeles Chargers at Buffalo Bills
• Projected Favorite: Bills (77.34% win probability)
• Spread: Buffalo (-7)
• Total: 50.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Buffalo vs. Los Angeles with FanDuel Sportsbook.

Giants vs. Titans

The New York Giants (1-1) are slated to do battle against the Tennessee Titans (0-2) at MetLife Stadium on Sunday, Sept. 27 at 1 p.m. ET. Both teams lost their previous game, as the Giants were defeated by the Rams 28-6, and the Titans lost 24-20 to the Eagles.

• Game Preview: Tennessee Titans at New York Giants
• Projected Favorite: Giants (66.24% win probability)
• Spread: New York (-2.5)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Tennessee with FanDuel Sportsbook.

Lions vs. Jets

The Detroit Lions (1-1) and the New York Jets (1-1), who both lost their last tilt, will go head to head at 1 p.m. ET on Sunday, Sept. 27. In their previous games, the Lions lost 41-31 to the Bills, and the Jets were defeated by the Packers 20-17.

• Game Preview: New York Jets at Detroit Lions
• Projected Favorite: Lions (84.49% win probability)
• Spread: Detroit (-6.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. New York with FanDuel Sportsbook.

Browns vs. Panthers

After claiming a 34-3 victory against the Falcons in their last contest, the Carolina Panthers (1-1) will visit the Cleveland Browns (1-1), who are coming off a 23-19 win over the Buccaneers, at Huntington Bank Field. Kickoff is slated for 1 p.m. ET on Sunday, Sept. 27.

• Game Preview: Carolina Panthers at Cleveland Browns
• Projected Favorite: Panthers (54.38% win probability)
• Spread: Carolina (-2.5)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Carolina with FanDuel Sportsbook.

Jaguars vs. Patriots

The Jacksonville Jaguars (1-1) are slated to collide with the New England Patriots (1-1) at EverBank Stadium on Sunday, Sept. 27 at 1 p.m. ET. In their last tilts, the Jaguars were defeated by the Broncos 20-13, and the Patriots won 20-3 against the Steelers.

• Game Preview: New England Patriots at Jacksonville Jaguars
• Projected Favorite: Jaguars (60.40% win probability)
• Spread: Jacksonville (-2.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. New England with FanDuel Sportsbook.

Commanders vs. Seahawks

The Seattle Seahawks (2-0) visit the Washington Commanders (0-2) on Sunday at 1 p.m. ET, in a matchup between a pair of outstanding pass-catchers in Jaxon Smith-Njigba and Stefon Diggs.

• Game Preview: Seattle Seahawks at Washington Commanders
• Projected Favorite: Seahawks (67.72% win probability)
• Spread: Seattle (-6.5)
• Total: 40.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. Seattle with FanDuel Sportsbook.

Buccaneers vs. Vikings

One of the best pass-catchers in football will be on show when Justin Jefferson and the Minnesota Vikings (2-0) visit the Tampa Bay Buccaneers (0-2) on Sunday, September 27, 2026.

• Game Preview: Minnesota Vikings at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (52.07% win probability)
• Spread: Minnesota (-1.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Minnesota with FanDuel Sportsbook.

49ers vs. Cardinals

A pair of the best offensive performers in football will be on display when QB Brock Purdy and the San Francisco 49ers (2-0) host pass-catcher Trey McBride and the Arizona Cardinals (1-1) on Sunday, September 27, 2026.

• Game Preview: Arizona Cardinals at San Francisco 49ers
• Projected Favorite: 49ers (80.68% win probability)
• Spread: San Francisco (-8.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Arizona with FanDuel Sportsbook.

Cowboys vs. Ravens

At Maracanã Stadium on Sunday, Derrick Henry and the Baltimore Ravens (1-1) play Dak Prescott and the Dallas Cowboys (1-1) in a battle featuring two of the brightest stars in football on offense, beginning at 4:25 p.m. ET.

• Game Preview: Baltimore Ravens vs. Dallas Cowboys
• Projected Favorite: Ravens (60.04% win probability)
• Spread: Baltimore (-3)
• Total: 52.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: CBS/Paramount+

Bet on Dallas vs. Baltimore with FanDuel Sportsbook.

Saints vs. Raiders

On Sunday at 4:25 p.m. ET, a pair of the best offensive players in football will be on display when wideout Chris Olave and the New Orleans Saints (1-1) host running back Ashton Jeanty and the Las Vegas Raiders (2-0).

• Game Preview: Las Vegas Raiders at New Orleans Saints
• Projected Favorite: Saints (72.97% win probability)
• Spread: New Orleans (-3)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on New Orleans vs. Las Vegas with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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