Twins vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 11:11 p.m.

The Minnesota Twins are among the MLB teams busy on Wednesday, versus the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Twins vs Giants Game Info

• Minnesota Twins (73-84) vs. San Francisco Giants (65-92)
• Date: Wednesday, September 23, 2026
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Twins.TV

Twins vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-134) | SF: (+114)
• Spread: MIN: -1.5 (+134) | SF: +1.5 (-162)
• Total: 7.5 -- Over: (+108) | Under: (-132)

Twins vs Giants Probable Starting Pitchers

Probable Pitchers: Connor Prielipp (Twins) - 6-7, 4.94 ERA vs César Perdomo (Giants) - 0-1, 3.72 ERA

The Twins will look to Connor Prielipp (6-7) versus the Giants and Cesar Perdomo (0-1). Prielipp and his team are 12-9-0 ATS this season when he starts. Prielipp's team has won 80% of his starts when they are favored on the moneyline (4-1). The Giants have a 1-2-0 record against the spread in Perdomo's starts. The Giants were named the moneyline underdog for three Perdomo starts this season -- they lost every time.

Twins vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (50.2%)

Twins vs Giants Moneyline

• The Twins vs Giants moneyline has Minnesota as a -134 favorite, while San Francisco is a +114 underdog at home.

Twins vs Giants Spread

• The Twins are favored by 1.5 runs on the road versus the Giants. The Twins are +134 to cover the spread, while the Giants are -162.

Twins vs Giants Over/Under

• An over/under of 7.5 has been set for Twins-Giants on Sept. 23, with the over being +108 and the under -132.

Bet on Minnesota Twins vs. San Francisco Giants on FanDuel today!

Twins vs Giants Betting Trends

• The Twins have been favorites in 57 games this season and have come away with the win 30 times (52.6%) in those contests.
• Minnesota has a record of 11-10 when favored by -134 or more this year.
• The Twins and their opponents have hit the over in 86 of their 153 games with a total set by oddsmakers this season.
• The Twins have posted a record of 81-72-0 against the spread this season.
• The Giants have won 37% of the games this season they were the underdog on the moneyline (40-68).
• San Francisco has a 23-39 record (winning just 37.1% of its games) when it has played as a moneyline underdog of +114 or longer.
• The Giants have combined with opponents to hit the over on the total 76 times this season for a 76-68-10 record against the over/under.
• The Giants have a 74-80-0 record against the spread this season.

Twins Player Leaders

• Brooks Lee leads Minnesota in slugging percentage (.434) thanks to 51 extra-base hits. He has a .253 batting average and an on-base percentage of .301.
• Among all qualifying batters in the majors, his batting average ranks 75th, his on-base percentage ranks 115th, and he is 60th in slugging.
• Lee has recorded a base hit in six games in a row. During his last 10 outings he is batting .351 with a double, a home run, two walks and three RBIs.
• Josh Bell has 28 doubles, a triple, 20 home runs and 49 walks. He's batting .258 and slugging .421 with an on-base percentage of .320.
• Among qualifying hitters, his batting average ranks him 68th, his on-base percentage 88th, and his slugging percentage 73rd.
• Bell enters this game looking to extend his five-game hit streak. During his last five outings he is batting .364 with a walk and four RBIs.
• Luke Keaschall leads Minnesota in OBP (.367) this season, fueled by 141 hits.
• Kody Clemens has 120 hits, which leads Minnesota hitters this season, while batting .234 with 55 extra-base hits.

Giants Player Leaders

• Drew Gilbert has 14 doubles, three triples, 11 home runs and 37 walks while batting .237. He's slugging .396 with an on-base percentage of .327.
• Marcelo Mayer has 10 doubles, three home runs and 16 walks while hitting .215. He's slugging .306 with an on-base percentage of .277.
• Christian Koss is batting .230 with six doubles, four home runs and nine walks.
• Jonah Cox has three doubles, two triples, four home runs and eight walks while hitting .280.

Twins vs Giants Head to Head

• 9/21/2026: 5-2 SF (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/11/2025: 7-6 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/10/2025: 2-1 MIN (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 3-1 MIN (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/14/2024: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/13/2024: 4-2 MIN (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/12/2024: 7-1 SF (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/24/2023: 7-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/23/2023: 4-3 SF (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/22/2023: 4-1 SF (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

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