Twins vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 3:11 p.m.

The Minnesota Twins are among the MLB teams busy on Wednesday, versus the San Francisco Giants.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Giants Game Info

• Minnesota Twins (74-84) vs. San Francisco Giants (65-93)
• Date: Wednesday, September 23, 2026
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Twins.TV

Twins vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-134) | SF: (+114)
• Spread: MIN: -1.5 (+134) | SF: +1.5 (-162)
• Total: 7.5 -- Over: (+108) | Under: (-132)

Twins vs Giants Probable Starting Pitchers

Probable Pitchers: Connor Prielipp (Twins) - 6-7, 4.94 ERA vs César Perdomo (Giants) - 0-1, 3.72 ERA

The probable starters are Connor Prielipp (6-7) for the Twins and Cesar Perdomo (0-1) for the Giants. Prielipp's team is 12-9-0 against the spread in his starts this season. Prielipp's team has been victorious in 80% of the games he's started as the moneyline favorite with a record of 4-1. The Giants have gone 1-2-0 ATS in Perdomo's three starts that had a set spread. The Giants were the moneyline underdog for three Perdomo starts this season -- they lost each time.

Twins vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (54%)

Twins vs Giants Moneyline

• San Francisco is a +114 underdog on the moneyline, while Minnesota is a -134 favorite on the road.

Twins vs Giants Spread

• The Twins are favored by 1.5 runs on the road against the Giants. The Twins are +134 to cover the spread, while the Giants are -162.

Twins vs Giants Over/Under

• An over/under of 7.5 has been set for Twins-Giants on Sept. 23, with the over being +108 and the under -132.

Bet on Minnesota Twins vs. San Francisco Giants on FanDuel today!

Twins vs Giants Betting Trends

• The Twins have been favorites in 58 games this season and have come away with the win 31 times (53.4%) in those contests.
• This year Minnesota has won 12 of 22 games when listed as at least -134 on the moneyline.
• The Twins and their opponents have gone over in 86 of their 154 games with a total set by sportsbooks this season.
• In 154 games with a line this season, the Twins have a mark of 81-73-0 against the spread.
• The Giants have gone 40-69 in games they were listed as the moneyline underdog (winning 36.7% of those games).
• San Francisco has gone 23-39 when it has played as a moneyline underdog with odds of +114 or longer (37.1%).
• The Giants have played in 155 games with an over/under set, and have combined with opponents to go over the total 76 times (76-69-10).
• The Giants have covered 48.4% of their games this season, going 75-80-0 ATS.

Twins Player Leaders

• Brooks Lee has an OPS of .736, fueled by an OBP of .302 and a team-best slugging percentage of .434 this season. He has a .255 batting average.
• He ranks 71st in batting average, 115th in on-base percentage, and 62nd in slugging among all qualifying batters in baseball.
• Lee will look for his eighth straight game with a hit in this contest. In his last 10 outings he is batting .342 with a double, a home run, two walks and four RBIs.
• Josh Bell is hitting .256 with 28 doubles, a triple, 20 home runs and 49 walks. He's slugging .418 with an on-base percentage of .318.
• Among qualifiers, he is 70th in batting average, 92nd in on-base percentage and 76th in slugging percentage.
• Luke Keaschall leads Minnesota in OBP (.367) this season, fueled by 142 hits.
• Kody Clemens leads Minnesota in total hits (121) this season while batting .234 with 55 extra-base hits.

Giants Player Leaders

• Drew Gilbert is hitting .238 with 14 doubles, three triples, 11 home runs and 37 walks. He's slugging .396 with an on-base percentage of .327.
• Marcelo Mayer is batting .215 with 10 doubles, three home runs and 16 walks. He's slugging .306 with an on-base percentage of .277.
• Christian Koss has six doubles, four home runs and nine walks while hitting .232.
• Jonah Cox is hitting .272 with three doubles, two triples, four home runs and nine walks.

Twins vs Giants Head to Head

• 9/22/2026: 3-2 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/21/2026: 5-2 SF (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/11/2025: 7-6 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/10/2025: 2-1 MIN (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 3-1 MIN (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/14/2024: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/13/2024: 4-2 MIN (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/12/2024: 7-1 SF (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/24/2023: 7-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/23/2023: 4-3 SF (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

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