Clemson vs Cal Prediction, Odds, Picks, Best Bets for Week 4 2026

The Clemson Tigers will face the California Golden Bears in college football action on Friday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Clemson vs Cal Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-114) | Cal: (-105)
• Spread: Clemson: -1.5 (-108) | Cal: +1.5 (-112)
• Total: 51.5 -- Over: (-104) | Under: (-118)

Clemson vs Cal Betting Trends

• Clemson hasn won once against the spread this season.
• Clemson has won once ATS (1-1) as a 1.5-point or higher favorite this season.
• Two of three Clemson games have hit the over this season.
• Cal has one win against the spread this season.
• Cal has one win ATS (1-1) as a 1.5-point underdog or greater this season.
• Cal has had one game (of three) hit the over this season.

Clemson vs Cal Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (63.2%)

Clemson vs Cal Point Spread

Cal is listed as an underdog by 1.5 points (-112 odds), and Clemson, the favorite, is -108 to cover.

Clemson vs Cal Over/Under

A combined point total of 51.5 has been set for Clemson-Cal on Sept. 25, with the over at -104 and the under at -118.

Clemson vs Cal Moneyline

Looking at the moneyline for Clemson-Cal, Clemson is the favorite at -114, and Cal is -105.

Clemson vs. Cal Points Insights

Clemson vs. Cal Game Info

• Game day: Friday, September 25, 2026
• Game time: 10:30 p.m. ET
• TV channel: ESPN
• Location: Berkeley, California
• Stadium: California Memorial Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Clemson vs. Cal analysis on FanDuel Research.