Indiana vs Northwestern Prediction, Odds, Picks, Best Bets for Week 4 2026

The Indiana Hoosiers will take on the Northwestern Wildcats in college football action on Friday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

Indiana vs Northwestern Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Indiana: (-1786) | Northwestern: (+920)
• Spread: Indiana: -19.5 (-120) | Northwestern: +19.5 (-102)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Indiana vs Northwestern Betting Trends

• Indiana has no wins against the spread this year.
• Indiana has yet to win ATS (0-3) when playing as at least 19.5-point favorites this year.
• Indiana has had one game (of three) go over the total this year.
• Northwestern has posted two wins against the spread this year.
• One Northwestern game (out of two) has gone over the point total this year.

Indiana vs Northwestern Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hoosiers win (85.5%)

Indiana vs Northwestern Point Spread

Indiana is favored by 19.5 points over Northwestern. Indiana is -120 to cover the spread, with Northwestern being -102.

Indiana vs Northwestern Over/Under

A combined point total of 49.5 has been set for Indiana-Northwestern on Sept. 25, with the over at -110 and the under at -110.

Indiana vs Northwestern Moneyline

The Indiana vs Northwestern moneyline has Indiana as a -1786 favorite, while Northwestern is a +920 underdog.

Indiana vs. Northwestern Points Insights

Indiana vs. Northwestern Game Info

• Game day: Friday, September 25, 2026
• Game time: 8 p.m. ET
• TV channel: FOX
• Location: Bloomington, Indiana
• Stadium: Memorial Stadium (Bloomington, IN)

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Check out even more in-depth Indiana vs. Northwestern analysis on FanDuel Research.