NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 16

The Week 16 NFL schedule includes top teams in play. Among those games is the Philadelphia Eagles playing the Washington Commanders.

Read through our odds breakdown for the NFL's Week 16.

Chargers vs. Broncos

The Los Angeles Chargers will host the Denver Broncos on Thursday at 8:15 p.m. ET.

• Matchup: Denver Broncos at Los Angeles Chargers
• Projected Favorite: Broncos (51.32% win probability)
• Spread: Los Angeles (-2.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Los Angeles vs. Denver with FanDuel Sportsbook.

Chiefs vs. Texans

One of the best running backs in football will be on display when Joe Mixon and the Houston Texans visit the Kansas City Chiefs on Saturday, December 21, 2024.

• Matchup: Houston Texans at Kansas City Chiefs
• Projected Favorite: Chiefs (65.24% win probability)
• Spread: Kansas City (-3.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: NBC

Bet on Kansas City vs. Houston with FanDuel Sportsbook.

Ravens vs. Steelers

The 4:30 p.m. ET tilt on Dec. 21 between the Baltimore Ravens (9-5) and the Pittsburgh Steelers (10-4) should be a fun matchup, as Derrick Henry has been one of the league's top runners this year, and the Steelers have a top-five run defense, ranking fourth-best in the NFL at 94.4 rushing yards surrendered per game.

• Matchup: Pittsburgh Steelers at Baltimore Ravens
• Projected Favorite: Ravens (70.80% win probability)
• Spread: Baltimore (-7)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 4:30 p.m. ET
• Channel: FOX

Bet on Baltimore vs. Pittsburgh with FanDuel Sportsbook.

Commanders vs. Eagles

On Sunday at 1 p.m. ET, two of the best offensive performers in football will be on display when running back Saquon Barkley and the Philadelphia Eagles visit quarterback Jayden Daniels and the Washington Commanders.

• Matchup: Philadelphia Eagles at Washington Commanders
• Projected Favorite: Eagles (52.67% win probability)
• Spread: Philadelphia (-4.5)
• Total: 46.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. Philadelphia with FanDuel Sportsbook.

Bears vs. Lions

After going down 48-42 to the Bills in their last contest, the Detroit Lions (12-2) will visit the Chicago Bears (4-10), who are coming off a 30-12 loss to the Vikings, at Soldier Field. Kickoff is slated for 1 p.m. ET on Sunday, Dec. 22.

• Matchup: Detroit Lions at Chicago Bears
• Projected Favorite: Lions (76.43% win probability)
• Spread: Detroit (-6.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. Detroit with FanDuel Sportsbook.

Colts vs. Titans

Against the Indianapolis Colts (6-8), who own the 30th-ranked run defense this season, Tony Pollard and the Tennessee Titans (3-11) shouldn't have any trouble running the ball when the two teams come together on Sunday, Dec. 22 at 1 p.m. ET. Pollard has been one of the NFL's top runners this season, ranking eighth-best in the league in rushing yards.

• Matchup: Tennessee Titans at Indianapolis Colts
• Projected Favorite: Colts (67.55% win probability)
• Spread: Indianapolis (-3.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Tennessee with FanDuel Sportsbook.

Falcons vs. Giants

One of the top pass-catchers in football will be on show when Drake London and the Atlanta Falcons host the New York Giants on Sunday, December 22, 2024.

• Matchup: New York Giants at Atlanta Falcons
• Projected Favorite: Falcons (78.03% win probability)
• Spread: Atlanta (-9.5)
• Total: 43.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Atlanta vs. New York with FanDuel Sportsbook.

Bengals vs. Browns

The Cincinnati Bengals (6-8), who sport the NFL's fifth-ranked scoring offense, host the Cleveland Browns (3-11) and their 30th-ranked scoring offense on Sunday, Dec. 22 at 1 p.m. ET. The Bengals average 28.5 points per game, while the Browns produce 17.1.

• Matchup: Cleveland Browns at Cincinnati Bengals
• Projected Favorite: Bengals (78.47% win probability)
• Spread: Cincinnati (-9.5)
• Total: 46.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. Cleveland with FanDuel Sportsbook.

Panthers vs. Cardinals

Trey McBride will lead the Arizona Cardinals into their matchup against the Carolina Panthers at Bank of America Stadium on Sunday at 1 p.m. ET.

• Matchup: Arizona Cardinals at Carolina Panthers
• Projected Favorite: Cardinals (63.14% win probability)
• Spread: Arizona (-4.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Arizona with FanDuel Sportsbook.

Jets vs. Rams

One of the top running backs in football will be on display when Kyren Williams and the Los Angeles Rams visit the New York Jets on Sunday, December 22, 2024.

• Matchup: Los Angeles Rams at New York Jets
• Projected Favorite: Rams (53.46% win probability)
• Spread: Los Angeles (-3)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Los Angeles with FanDuel Sportsbook.

Seahawks vs. Vikings

On Sunday at 4:05 p.m. ET, a pair of excellent pass-catchers will be featured when Justin Jefferson and the Minnesota Vikings visit Jaxon Smith-Njigba and the Seattle Seahawks.

• Matchup: Minnesota Vikings at Seattle Seahawks
• Projected Favorite: Vikings (54.35% win probability)
• Spread: Minnesota (-2.5)
• Total: 42.5 -- Over: (-120) | Under: (-102)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Seattle vs. Minnesota with FanDuel Sportsbook.

Raiders vs. Jaguars

Against the Jacksonville Jaguars (3-11), who own the worst pass defense this season, Brock Bowers and the Las Vegas Raiders (2-12) shouldn't have any trouble moving the ball through the air when the two teams square off on Sunday, Dec. 22 at 4:25 p.m. ET. Bowers has been one of the NFL's top receivers this year, ranking ninth-best in the league in receiving yards.

• Matchup: Jacksonville Jaguars at Las Vegas Raiders
• Projected Favorite: Raiders (56.03% win probability)
• Spread: Las Vegas (-2.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Jacksonville with FanDuel Sportsbook.

Dolphins vs. 49ers

The San Francisco 49ers (6-8) are scheduled to match up with the Miami Dolphins (6-8) at Hard Rock Stadium on Sunday, Dec. 22 at 4:25 p.m. ET. Both squads lost their last tilt, as the 49ers were defeated by the Rams 12-6, and the Dolphins lost 20-12 to the Texans.

• Matchup: San Francisco 49ers at Miami Dolphins
• Projected Favorite: 49ers (58.57% win probability)
• Spread: San Francisco (-1.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Miami vs. San Francisco with FanDuel Sportsbook.

Bills vs. Patriots

One of the best QBs in football will be featured when Josh Allen and the Buffalo Bills host the New England Patriots on Sunday, December 22, 2024.

• Matchup: New England Patriots at Buffalo Bills
• Projected Favorite: Bills (88.15% win probability)
• Spread: Buffalo (-14.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Buffalo vs. New England with FanDuel Sportsbook.

Cowboys vs. Buccaneers

The Tampa Bay Buccaneers (8-6) and their 30th-ranked pass defense might have a hard time slowing down the Dallas Cowboys (6-8) and CeeDee Lamb, one of the NFL's top receivers, when the Cowboys host the Buccaneers at AT&T Stadium on Dec. 22 at 8:20 p.m. ET.

• Matchup: Tampa Bay Buccaneers at Dallas Cowboys
• Projected Favorite: Buccaneers (68.05% win probability)
• Spread: Tampa Bay (-3.5)
• Total: 47.5 -- Over: (-110) | Under: (-110)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on Dallas vs. Tampa Bay with FanDuel Sportsbook.

Packers vs. Saints

Star running back Josh Jacobs and the Green Bay Packers face the New Orleans Saints on Monday at 8:15 p.m. ET at Lambeau Field.

• Matchup: New Orleans Saints at Green Bay Packers
• Projected Favorite: Packers (83.58% win probability)
• Spread: Green Bay (-14.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 8:15 p.m. ET
• Channel: ESPN

Bet on Green Bay vs. New Orleans with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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