Thursday’s MLB Strikeout Props - May 21

Will José Soriano strike out more than 6.5 batters? Can Cade Cavalli record more than 4.5 strikeouts? See their odds and more strikeout prop odds for all pitchers in MLB play on May 21, in the article below.

Today's MLB Strikeout Props

Cleveland Guardians at Detroit Tigers

• Casey Mize (Tigers): Over/Under 4.5 Ks (Over +100, Under -122) | 2026 Stats: 5.4 strikeouts per game in 8 appearances

Pittsburgh Pirates at St. Louis Cardinals

• Braxton Ashcraft (Pirates): Over/Under 5.5 Ks (Over +116, Under -154) | 2026 Stats: 6.5 strikeouts per game in 10 appearances
• Dustin May (Cardinals): Over/Under 4.5 Ks (Over -134, Under +110) | 2026 Stats: 4.2 strikeouts per game in 10 appearances

New York Mets at Washington Nationals

• David Peterson (Mets): Over/Under 4.5 Ks (Over -112, Under -118) | 2026 Stats: 4.5 strikeouts per game in 11 appearances
• Cade Cavalli (Nationals): Over/Under 4.5 Ks (Over -144, Under +118) | 2026 Stats: 5.5 strikeouts per game in 11 appearances

Toronto Blue Jays at New York Yankees

• Carlos Rodon (Yankees): Over/Under 5.5 Ks (Over +118, Under -144) | 2026 Stats: 5 strikeouts per game in 2 appearances

Colorado Rockies at Arizona Diamondbacks

• Eduardo Rodríguez (Diamondbacks): Over/Under 5.5 Ks (Over +110, Under -134) | 2026 Stats: 4.3 strikeouts per game in 9 appearances

Athletics at Los Angeles Angels

• José Soriano (Angels): Over/Under 6.5 Ks (Over +106, Under -130) | 2026 Stats: 6.7 strikeouts per game in 10 appearances
• Luis Severino (Athletics): Over/Under 5.5 Ks (Over -136, Under +102) | 2026 Stats: 5.4 strikeouts per game in 10 appearances