Mets vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 12:12 a.m.

The Thursday schedule in MLB includes a matchup between the New York Mets and the Washington Nationals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Mets vs Nationals Game Info

• New York Mets (21-28) vs. Washington Nationals (25-25)
• Date: Thursday, May 21, 2026
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and SNY

Mets vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYM: (-112) | WSH: (-104)
• Spread: NYM: -1.5 (+146) | WSH: +1.5 (-178)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Mets vs Nationals Probable Starting Pitchers

Probable Pitchers: David Peterson (Mets) - 2-4, 5.40 ERA vs Cade Cavalli (Nationals) - 2-2, 4.05 ERA

This contest's pitching matchup is set, as the Mets will send David Peterson (2-4) to the mound, while Cade Cavalli (2-2) will take the ball for the Nationals. Peterson's team is 1-4-0 against the spread this season in his starts. Peterson's team has been victorious in 25% of the games he's started as the moneyline favorite with a record of 1-3. The Nationals have a 6-4-0 ATS record in Cavalli's 10 starts with a set spread. The Nationals are 2-6 in Cavalli's eight starts this season that they were the moneyline underdog.

Mets vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (53.8%)

Mets vs Nationals Moneyline

• New York is a -112 favorite on the moneyline, while Washington is a -104 underdog at home.

Mets vs Nationals Spread

• The Nationals are +1.5 on the run line against the Mets. The Nationals are -178 to cover, and the Mets are +146.

Mets vs Nationals Over/Under

• A total of 8.5 runs has been set for the Mets-Nationals contest on May 21, with the over available at -105 and the under at -115.

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Mets vs Nationals Betting Trends

• The Mets have been chosen as favorites in 37 games this year and have walked away with the win 18 times (48.6%) in those games.
• New York has a record of 18-19 in contests when oddsmakers favor them by -112 or more on the moneyline.
• The Mets and their opponents have gone over the total this season in 21 of their 49 opportunities.
• The Mets have posted a record of 20-29-0 against the spread this season.
• The Nationals have won 48.9% of the games this season they were the moneyline underdog (23-24).
• When playing as a moneyline underdog with odds of -104 or longer, Washington has gone 23-23 (50%).
• The Nationals have played in 50 games with a set over/under, and have combined with their opponents to go over the total 32 times (32-15-3).
• The Nationals have collected a 29-21-0 record against the spread this season (covering 58% of the time).

Mets Player Leaders

• Juan Soto is hitting .299 with four doubles, a triple, nine home runs and 20 walks. He has an on-base percentage of .392 and a slugging percentage of .559.
• Soto hopes to build on a seven-game hitting streak in this matchup. In his last 10 outings he is hitting .359 with five home runs, six walks and 10 RBIs.
• Bo Bichette has hit five homers this season while driving in 25 runs. He's batting .225 this season and slugging .330 with an on-base percentage of .276.
• He is 130th in batting average, 155th in on-base percentage and 149th in slugging in MLB.
• Bichette heads into this game looking to extend his four-game hit streak. During his last five outings he is batting .318 with a double, three home runs, two walks and seven RBIs.
• Carson Benge has 42 hits this season and a team-best OBP of .320.
• Benge has picked up a hit in five straight games. During his last five outings he is hitting .458 with two doubles, a walk and four RBIs.
• Mark Vientos leads New York in total hits (35) this season while batting .240 with 14 extra-base hits.
• Vientos takes a two-game hitting streak into this matchup. During his last five outings he is batting .273 with three doubles and three RBIs.

Nationals Player Leaders

• C.J. Abrams has a team-high slugging percentage (.539) while pacing the Nationals in hits (54). He's batting .300 and with an on-base percentage of .389.
• Including all the qualified hitters in the majors, he is 15th in batting average, 18th in on-base percentage and 14th in slugging percentage.
• James Wood has a .392 on-base percentage to pace his team. He has a batting average of .254 while slugging .523.
• His batting average ranks 82nd among all qualified players, his on-base percentage is 16th, and he is 19th in slugging.
• Daylen Lile is hitting .264 with 13 doubles, seven home runs and 17 walks.
• Jacob Young has six doubles, six home runs and nine walks while hitting .231.

Mets vs Nationals Head to Head

• 5/20/2026: 8-4 WSH (Favorite: Mets, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/19/2026: 9-6 WSH (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/18/2026: 16-7 NYM (Favorite: Mets, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/30/2026: 5-4 WSH (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/29/2026: 14-2 WSH (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/28/2026: 8-0 NYM (Favorite: Mets, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/21/2025: 3-2 WSH (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/20/2025: 5-3 WSH (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/19/2025: 12-6 NYM (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 8/21/2025: 9-3 WSH (Favorite: Mets, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)

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