Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 12:12 a.m.

The Cleveland Guardians versus the Minnesota Twins is on the MLB schedule for Thursday.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Twins Game Info

• Cleveland Guardians (17-13) vs. Minnesota Twins (13-18)
• Date: Thursday, May 1, 2025
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: MLB Network, CLEG, and MNNT

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | MIN: (-102)
• Spread: CLE: +1.5 (-192) | MIN: -1.5 (+158)
• Total: 9 -- Over: (-105) | Under: (-115)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Edward Lively (Guardians) - 1-2, 4.40 ERA vs Simeon Woods Richardson (Twins) - 2-2, 4.07 ERA

The probable pitchers are Edward Lively (1-2) for the Guardians and Simeon Woods Richardson (2-2) for the Twins. Lively and his team have a record of 3-3-0 against the spread when he starts. Lively's team won his only start as a favorite this season. The Twins are 3-1-0 ATS in Richardson's four starts with a set spread. The Twins were named the moneyline underdog for one Richardson start this season -- they lost.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.3%)

Guardians vs Twins Moneyline

• Minnesota is a -102 underdog on the moneyline, while Cleveland is a -116 favorite at home.

Guardians vs Twins Spread

• The Twins are 1.5-run favorites against the spread for this matchup with the Guardians. The Twins are +158 to cover, while the Guardians are -192 to cover as a 1.5-run underdog on the runline.

Guardians vs Twins Over/Under

• An over/under of 9 has been set for Guardians-Twins on May 1, with the over being -105 and the under -115.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been victorious in eight, or 72.7%, of the 11 contests they have been chosen as favorites in this season.
• Cleveland has a record of 8-2 when favored by -116 or more this year.
• The Guardians and their opponents have gone over the total this season in 16 of their 29 opportunities.
• The Guardians are 13-16-0 against the spread in their 29 games that had a posted line this season.
• The Twins have won 14.3% of the games this season they were the moneyline underdog (1-6).
• When playing as a moneyline underdog with odds of -102 or longer, Minnesota has a record of 1-5 (16.7%).
• The Twins have combined with opponents to go over the total 11 times this season for an 11-16-3 record against the over/under.
• The Twins are 15-15-0 against the spread this season.

Guardians Player Leaders

• Steven Kwan has an OPS of .836, fueled by an OBP of .370 to go with a slugging percentage of .466. He has a .322 batting average, as well.
• He is 10th in batting average, 34th in on-base percentage, and 45th in slugging among all qualified hitters in baseball.
• Jose Ramirez is hitting .264 with five doubles, five home runs and nine walks. He's slugging .453 with an on-base percentage of .317.
• Among qualifiers, he is 63rd in batting average, 86th in on-base percentage and 55th in slugging percentage.
• Kyle Manzardo has 20 hits and is batting .220 this season.
• Gabriel Arias has four home runs, 11 RBI and a batting average of .264 this season.

Twins Player Leaders

• Ty France has accumulated a team-best OBP (.341) and slugging percentage (.404). He's batting .266.
• He ranks 59th in batting average, 58th in on-base percentage and 87th in slugging percentage among all qualified hitters in the majors.
• France hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .450 with three doubles, a home run and six RBI.
• Byron Buxton's 26 hits lead his team. He has a batting average of .239 while slugging .477 with an on-base percentage of .274.
• He is 92nd in batting average, 133rd in on-base percentage and 39th in slugging percentage in MLB.
• Trevor Larnach has two doubles, four home runs and 14 walks while hitting .236.
• Ryan Jeffers is hitting .256 with seven doubles, a home run and nine walks.

Guardians vs Twins Head to Head

• 4/30/2025: 4-2 CLE (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2025: 11-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/17/2024: 4-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2024: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2024: 5-3 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/9/2024: 6-3 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/9/2024: 4-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/19/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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