Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 12:12 p.m.

MLB action on Thursday includes the Minnesota Twins playing the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Twins vs Guardians Game Info

• Minnesota Twins (13-18) vs. Cleveland Guardians (17-13)
• Date: Thursday, May 1, 2025
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: MLB Network, CLEG, and MNNT

Twins vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-116) | CLE: (-102)
• Spread: MIN: -1.5 (+136) | CLE: +1.5 (-164)
• Total: 9 -- Over: (-118) | Under: (-104)

Twins vs Guardians Probable Starting Pitchers

Probable Pitchers: Simeon Woods Richardson (Twins) - 2-2, 4.07 ERA vs Edward Lively (Guardians) - 1-2, 4.40 ERA

The Twins will give the nod to Simeon Woods Richardson (2-2) versus the Guardians and Edward Lively (1-2). Richardson's team is 3-1-0 against the spread in his starts this season. Richardson and his team have won each of the three games he's started as the moneyline favorite. The Guardians are 3-3-0 against the spread when Lively starts. The Guardians are 3-2 in Lively's five starts this season that they were the moneyline underdog.

Twins vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.1%)

Twins vs Guardians Moneyline

• Minnesota is a -116 favorite on the moneyline, while Cleveland is a -102 underdog at home.

Twins vs Guardians Spread

• The Twins are 1.5-run road favorites on the runline against the Guardians. The Twins are +136 to cover, and the Guardians are -164.

Twins vs Guardians Over/Under

• Twins versus Guardians on May 1 has an over/under of 9 runs, with the odds on the over -118 and the under set at -104.

Bet on Minnesota Twins vs. Cleveland Guardians on FanDuel today!

Twins vs Guardians Betting Trends

• The Twins have been favorites in 22 games this season and have come away with the win 11 times (50%) in those contests.
• This season Minnesota has been victorious 10 times in 16 chances when named as a favorite of at least -116 on the moneyline.
• The Twins and their opponents have gone over the total this season in 11 of their 30 opportunities.
• The Twins are 15-15-0 against the spread in their 30 games that had a posted line this season.
• The Guardians have won 44.4% of the games this season they were the moneyline underdog (8-10).
• Cleveland has a 5-8 record (winning only 38.5% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Guardians have played in 29 games with an over/under set, and have combined with opponents to go over the total 16 times (16-12-1).
• The Guardians have covered 44.8% of their games this season, going 13-16-0 ATS.

Twins Player Leaders

• Ty France leads Minnesota with an OBP of .341, plus a team-best slugging percentage of .404. He's batting .266 on the season.
• He is 59th in batting average, 58th in on-base percentage, and 87th in slugging among all qualified hitters in baseball.
• France has recorded a base hit in five games in a row. During his last five outings he is batting .450 with three doubles, a home run and six RBI.
• Byron Buxton has 26 hits, which ranks first among Minnesota batters this season. He's batting .239 with 12 extra-base hits. He's also slugging .477 with an on-base percentage of .274.
• He is 93rd in batting average, 134th in on-base percentage and 39th in slugging in the majors.
• Trevor Larnach has 25 hits this season and has a slash line of .236/.328/.368.
• Ryan Jeffers has been key for Minnesota with 20 hits, an OBP of .348 plus a slugging percentage of .385.
• Jeffers heads into this game on a four-game hitting streak. In his last five games he is batting .263 with two doubles, a home run, three walks and five RBI.

Guardians Player Leaders

• Steven Kwan has put up a .370 on-base percentage and a .466 slugging percentage, both team-best marks for the Guardians. He's batting .322.
• Including all the qualified hitters in MLB, he is 11th in batting average, 34th in on-base percentage and 45th in slugging percentage.
• Jose Ramirez has five doubles, five home runs and nine walks while hitting .264. He's slugging .453 with an on-base percentage of .317.
• He is currently 63rd in batting average, 86th in on-base percentage and 55th in slugging percentage among all qualifying hitters.
• Kyle Manzardo leads the Guardians with 20 hits.
• Gabriel Arias is batting .264 with six doubles, four home runs and six walks.

Twins vs Guardians Head to Head

• 4/30/2025: 4-2 CLE (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2025: 11-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/17/2024: 4-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2024: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2024: 5-3 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/9/2024: 6-3 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/9/2024: 4-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/19/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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