Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 18

Odds updated as of 6:12 p.m.

MLB action on Saturday includes the Cleveland Guardians taking on the Baltimore Orioles.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Orioles Game Info

• Cleveland Guardians (11-10) vs. Baltimore Orioles (10-10)
• Date: Saturday, April 18, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MASN

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | BAL: (+116)
• Spread: CLE: -1.5 (+155) | BAL: +1.5 (-188)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 2-1, 2.38 ERA vs Dean Kremer (Orioles) - 0-0, 3.60 ERA

The probable pitchers are Gavin Williams (2-1) for the Guardians and Dean Kremer for the Orioles. Williams' team is 3-1-0 against the spread this season in his starts. Williams' team is 2-0 this season when he starts and they're favored on the moneyline. Kremer has started only one game with a set spread, which the Orioles covered. The Orioles have yet to be named a moneyline underdog when Kremer starts this season.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (52.8%)

Guardians vs Orioles Moneyline

• Cleveland is the favorite, -134 on the moneyline, while Baltimore is a +116 underdog on the road.

Guardians vs Orioles Spread

• The Orioles are at the Guardians, and are +1.5 on the runline. The Orioles are +155 to cover the spread, and the Guardians are -188.

Guardians vs Orioles Over/Under

• Guardians versus Orioles, on April 18, has an over/under of 7.5, with the over being +100 and the under -122.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have been favorites in six games this season and have come away with the win three times (50%) in those contests.
• Cleveland has played as a favorite of -134 or more just one time this year and came away with a loss in that game.
• The Guardians and their opponents have gone over the total this season in 10 of their 21 opportunities.
• The Guardians have posted a record of 12-9-0 against the spread this season.
• The Orioles have been the moneyline underdog six total times this season. They've finished 2-4 in those games.
• Baltimore has never played a game this season with moneyline odds of +116 or longer.
• The Orioles have played in 20 games with an over/under set, and have combined with their opponents to go over the total 11 times (11-9-0).
• The Orioles have covered 40% of their games this season, going 8-12-0 against the spread.

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.348) this season, fueled by 17 hits. He has a .221 batting average and a slugging percentage of .429.
• Among qualified batters, he is 126th in batting average, his on-base percentage ranks 63rd, and he is 75th in slugging.
• Chase DeLauter leads Cleveland with 16 hits. He is batting .246 this season and has 10 extra-base hits. He's also slugging .554 with an on-base percentage of .342.
• Among qualifying hitters, his batting average ranks him 91st, his on-base percentage 74th, and his slugging percentage 19th.
• Steven Kwan has hit one homer with a team-high .329 SLG this season.
• Kwan has recorded at least one base hit in three straight games. In his last five games he is hitting .273 with a double, a walk and three RBIs.
• Angel Martinez has two home runs, nine RBI and a batting average of .279 this season.

Orioles Player Leaders

• Gunnar Henderson is batting .200 with three doubles, a triple, six home runs and eight walks. He's slugging .471 with an on-base percentage of .274.
• Including all the qualified hitters in MLB, his batting average is 149th, his on-base percentage is 156th, and he is 54th in slugging.
• Taylor Ward's .394 on-base percentage and .418 slugging percentage are both team-highs. He has a batting average of .291.
• Including all qualified hitters, he is 34th in batting average, 24th in on-base percentage and 78th in slugging percentage.
• Jeremiah Jackson has put up 19 hits, a team-best for the Orioles.
• Pete Alonso is hitting .216 with five doubles, two home runs and 13 walks.

Guardians vs Orioles Head to Head

• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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