Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 18

Odds updated as of 1:12 a.m.

The MLB's Saturday slate includes the Cleveland Guardians facing the Baltimore Orioles.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Guardians vs Orioles Game Info

• Cleveland Guardians (11-10) vs. Baltimore Orioles (10-10)
• Date: Saturday, April 18, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MASN

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | BAL: (+108)
• Spread: CLE: -1.5 (+180) | BAL: +1.5 (-220)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 2-1, 2.38 ERA vs Dean Kremer (Orioles) - 0-0, 3.60 ERA

The Guardians will give the ball to Gavin Williams (2-1, 2.38 ERA), who is eyeing win No. 3 on the season, and the Orioles will turn to Dean Kremer. Williams and his team are 3-1-0 ATS this season when he starts. Williams' team is 2-0 this season when he starts and they're favored on the moneyline. Kremer has started just one game with a set spread, which the Orioles covered. The Orioles have yet to be named a moneyline underdog when Kremer starts this season.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (50.3%)

Guardians vs Orioles Moneyline

• Looking at the moneyline for Guardians-Orioles, Cleveland is the favorite at -126, and Baltimore is +108 playing on the road.

Guardians vs Orioles Spread

• The Orioles are +1.5 on the run line against the Guardians. The Orioles are -220 to cover, and the Guardians are +180.

Guardians vs Orioles Over/Under

• The over/under for the Guardians versus Orioles game on April 18 has been set at 7.5, with -106 odds on the over and -114 odds on the under.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have been favorites in six games this season and have come away with the win three times (50%) in those contests.
• This season Cleveland has been victorious one time in three chances when named as a favorite of at least -126 on the moneyline.
• The Guardians and their opponents have gone over in 10 of their 21 games with a total set by sportsbooks this season.
• The Guardians are 12-9-0 against the spread in their 21 games that had a posted line this season.
• The Orioles have been the moneyline underdog six total times this season. They've finished 2-4 in those games.
• Baltimore has played as a moneyline underdog of +108 or longer in just two games this season, which it split 1-1.
• The Orioles have played in 20 games with a set over/under, and have combined with opponents to go over the total 11 times (11-9-0).
• The Orioles have an 8-12-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with an OBP of .348 this season while batting .221 with 15 walks and 12 runs scored. He has a slugging percentage of .429.
• Among qualified hitters in the majors, he ranks 124th in batting average, 65th in on-base percentage, and 75th in slugging.
• Chase DeLauter leads Cleveland in total hits (16) this season while batting .246 with 10 extra-base hits. He's slugging .554 with an on-base percentage of .342.
• He ranks 91st in batting average, 75th in on-base percentage and 19th in slugging in the major leagues.
• Steven Kwan has hit one homer with a team-high .329 SLG this season.
• Kwan takes a three-game hitting streak into this game. In his last five games he is hitting .273 with a double, a walk and three RBIs.
• Angel Martinez has been key for Cleveland with 17 hits, an OBP of .333 plus a slugging percentage of .443.

Orioles Player Leaders

• Gunnar Henderson has three doubles, a triple, six home runs and eight walks while batting .200. He's slugging .471 with an on-base percentage of .274.
• Including all qualifying hitters in the majors, his batting average puts him 147th, his on-base percentage is 156th, and he is 53rd in slugging.
• Taylor Ward has a .394 on-base percentage while slugging .418. Both lead his team. He has a batting average of .291.
• Including all qualifying hitters, his batting average places him 36th, his on-base percentage ranks 26th, and he is 79th in slugging.
• Jeremiah Jackson leads the Orioles with 19 hits.
• Pete Alonso has five doubles, two home runs and 13 walks while batting .216.

Guardians vs Orioles Head to Head

• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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