Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 17

Odds updated as of 6:12 p.m.

Friday's slate in the MLB includes a matchup between the Cleveland Guardians and the Baltimore Orioles.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Guardians vs Orioles Game Info

• Cleveland Guardians (11-9) vs. Baltimore Orioles (9-10)
• Date: Friday, April 17, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MASN

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | BAL: (+114)
• Spread: CLE: -1.5 (+152) | BAL: +1.5 (-184)
• Total: 8 -- Over: (-110) | Under: (-110)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 0-2, 6.38 ERA vs Chris Bassitt (Orioles) - 0-2, 9.00 ERA

This contest's pitching matchup is set, as the Guardians will send Tanner Bibee (0-2) to the mound, while Chris Bassitt (0-2) will answer the bell for the Orioles. Bibee and his team have a record of 1-3-0 against the spread when he starts. Bibee's team lost his only start as a favorite this season. The Orioles have gone 1-2-0 ATS in Bassitt's three starts that had a set spread. The Orioles were named the moneyline underdog for two Bassitt starts this season -- they split the games.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (50.3%)

Guardians vs Orioles Moneyline

• Cleveland is a -134 favorite on the moneyline, while Baltimore is a +114 underdog on the road.

Guardians vs Orioles Spread

• The Orioles are +1.5 on the spread (-184 to cover), and Cleveland is +152 to cover the runline.

Guardians vs Orioles Over/Under

• The Guardians-Orioles game on April 17 has been given an over/under of 8 runs. The over is set at -110 and the under at -110.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have won in three of the five contests they have been named as odds-on favorites in this year.
• Oddsmakers have given Cleveland the best odds of winning it has seen this season, with a -134 moneyline listed for this contest.
• The Guardians and their opponents have gone over in nine of their 20 games with a total set by sportsbooks this season.
• The Guardians have an against the spread record of 12-8-0 in 20 games with a line this season.
• The Orioles have been the underdog on the moneyline five total times this season. They've finished 1-4 in those games.
• Baltimore has not yet played a game with moneyline odds of +114 or longer.
• The Orioles have played in 19 games with a set over/under, and have combined with their opponents to go over the total 10 times (10-9-0).
• The Orioles have gone 7-12-0 against the spread this season.

Guardians Player Leaders

• Jose Ramirez has four doubles, four home runs and 11 walks while batting .224. He has an on-base percentage of .322 and a slugging percentage of .434.
• Among qualifying hitters in the majors, his batting average ranks 118th, his on-base percentage ranks 107th, and he is 68th in slugging.
• Chase DeLauter leads Cleveland with 15 hits. He is batting .246 this season and has nine extra-base hits. He's also slugging .557 with an on-base percentage of .338.
• Among all qualifying batters, he is 91st in batting average, 84th in on-base percentage and 20th in slugging percentage.
• Angel Martinez leads Cleveland with an OBP of .339 this season while batting .281 with three walks and eight runs scored.
• Steven Kwan has an OPS of .659, fueled by an OBP of .325 and a team-best slugging percentage of .333 this season.
• Kwan has safely hit in two games in a row. During his last five outings he is batting .227 with a double, a walk and three RBIs.

Orioles Player Leaders

• Gunnar Henderson has racked up 17 hits, a team-best for the Orioles. He's batting .213 and slugging .500 with an on-base percentage of .289.
• Including all the qualifying hitters in MLB, he ranks 132nd in batting average, 144th in on-base percentage and 42nd in slugging percentage.
• Taylor Ward's .393 on-base percentage and .434 slugging percentage both pace his team. He has a batting average of .303.
• He is currently 30th in batting average, 24th in on-base percentage and 68th in slugging percentage among all qualifying hitters.
• Jeremiah Jackson is hitting .321 with two doubles and four home runs.
• Pete Alonso is batting .200 with five doubles, two home runs and 13 walks.

Guardians vs Orioles Head to Head

• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/3/2024: 7-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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