Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 16

Odds updated as of 1:12 a.m.

The Cleveland Guardians versus the Baltimore Orioles is on the MLB schedule for Thursday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Orioles Game Info

• Cleveland Guardians (10-9) vs. Baltimore Orioles (9-9)
• Date: Thursday, April 16, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MASN

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | BAL: (+110)
• Spread: CLE: -1.5 (+168) | BAL: +1.5 (-205)
• Total: 8 -- Over: (-110) | Under: (-110)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 2-0, 0.51 ERA vs Shane Baz (Orioles) - 0-1, 4.50 ERA

The probable pitchers are Parker Messick (2-0) for the Guardians and Shane Baz (0-1) for the Orioles. Messick and his team have covered in each of his three starts with a spread this season. This will be Messick's first game as the moneyline favorite this season. When Baz starts, the Orioles have gone 1-2-0 against the spread. The Orioles were the moneyline underdog for one Baz start this season -- they lost.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (59.2%)

Guardians vs Orioles Moneyline

• Baltimore is a +110 underdog on the moneyline, while Cleveland is a -130 favorite at home.

Guardians vs Orioles Spread

• The Guardians are hosting the Orioles and are favored by 1.5 runs on the spread. The Guardians are +168 to cover the runline, with the Orioles being -205.

Guardians vs Orioles Over/Under

• An over/under of 8 has been set for Guardians-Orioles on April 16, with the over being -110 and the under -110.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have been victorious in two of the four contests they have been chosen as favorites in this season.
• Cleveland has not played a game this season with better moneyline odds than -130.
• The Guardians and their opponents have gone over in nine of their 19 games with a total set by sportsbooks this season.
• The Guardians are 11-8-0 against the spread in their 19 games with a line set by sportsbooks this season.
• The Orioles are 1-3 in games they were the underdog on the moneyline (winning 25% of those games).
• Baltimore has not yet played a game with moneyline odds of +110 or longer.
• The Orioles have combined with opponents to hit the over on the total 10 times this season for a 10-8-0 record against the over/under.
• The Orioles have put together a 7-11-0 record ATS this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (15) this season while batting .259 with nine extra-base hits. He has an on-base percentage of .343 and a slugging percentage of .586.
• Among all qualified hitters in baseball, his batting average ranks 71st, his on-base percentage ranks 75th, and he is 12th in slugging.
• Jose Ramirez is hitting .205 with four doubles, three home runs and 10 walks, while slugging .384 with an on-base percentage of .301.
• He is 139th in batting average, 129th in on-base percentage and 97th in slugging among qualifying hitters.
• Angel Martinez leads Cleveland with an OBP of .362 this season while batting .302 with three walks and eight runs scored.
• Steven Kwan has an OPS of .640, fueled by an OBP of .316 and a team-best slugging percentage of .324 this season.

Orioles Player Leaders

• Gunnar Henderson is leading the Orioles with 17 hits. He's batting .221 and slugging .519 with an on-base percentage of .302.
• Including all qualified hitters in MLB, he is 120th in batting average, 128th in on-base percentage and 33rd in slugging percentage.
• Taylor Ward's .388 on-base percentage and .438 slugging percentage both lead his team. He has a batting average of .301.
• He is currently 31st in batting average, 24th in on-base percentage and 71st in slugging percentage among all qualifying hitters.
• Jeremiah Jackson has two doubles and four home runs while hitting .340.
• Pete Alonso has four doubles, two home runs and 13 walks while hitting .197.

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