Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 16

Odds updated as of 6:12 p.m.

The MLB's Thursday schedule includes the Cleveland Guardians facing the Baltimore Orioles.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Orioles Game Info

• Cleveland Guardians (10-9) vs. Baltimore Orioles (9-9)
• Date: Thursday, April 16, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MASN

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | BAL: (+110)
• Spread: CLE: -1.5 (+164) | BAL: +1.5 (-200)
• Total: 8 -- Over: (-102) | Under: (-120)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 2-0, 0.51 ERA vs Shane Baz (Orioles) - 0-1, 4.50 ERA

This contest's pitching matchup is set, as the Guardians will send Parker Messick (2-0) to the mound, while Shane Baz (0-1) will take the ball for the Orioles. Messick's team has covered the spread in each of the three opportunities this season. This will be Messick's first start this season with his team as the moneyline favorite. When Baz starts, the Orioles are 1-2-0 against the spread. The Orioles were named the moneyline underdog for one Baz start this season -- they lost.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (55%)

Guardians vs Orioles Moneyline

• Cleveland is the favorite, -130 on the moneyline, while Baltimore is a +110 underdog on the road.

Guardians vs Orioles Spread

• The Guardians are hosting the Orioles and are favored by 1.5 runs (+164 to cover) on the runline. Baltimore is -200 to cover.

Guardians vs Orioles Over/Under

• Guardians versus Orioles, on April 16, has an over/under of 8, with the over being -102 and the under -120.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have won in two of the four contests they have been named as odds-on favorites in this year.
• Cleveland has not played a game this season with better moneyline odds than -130.
• The Guardians and their opponents have gone over the total this season in nine of their 19 opportunities.
• The Guardians are 11-8-0 against the spread in their 19 games that had a posted line this season.
• The Orioles have gone 1-3 in games they were listed as the moneyline underdog (winning 25% of those games).
• Baltimore has yet to play a game with moneyline odds of +110 or longer.
• The Orioles have had an over/under set by bookmakers 18 times, and have combined with opponents to go over the total in 10 of those games (10-8-0).
• The Orioles have covered just 38.9% of their games this season, going 7-11-0 against the spread.

Guardians Player Leaders

• Chase DeLauter has 15 hits, which leads Cleveland hitters this season, while batting .259 with nine extra-base hits. He has an on-base percentage of .343 and a slugging percentage of .586.
• Among all qualifying hitters in MLB, he is 73rd in batting average, 77th in on-base percentage, and 14th in slugging.
• Jose Ramirez has four doubles, three home runs and 10 walks. He's batting .205 and slugging .384 with an on-base percentage of .301.
• Among all qualifying hitters, he is 137th in batting average, 129th in on-base percentage and 98th in slugging percentage.
• Angel Martinez leads Cleveland in OBP (.362) this season, fueled by 16 hits.
• Steven Kwan leads Cleveland with a slugging percentage of .324, fueled by four extra-base hits.

Orioles Player Leaders

• Gunnar Henderson has totaled 17 hits, a team-high for the Orioles. He's batting .221 and slugging .519 with an on-base percentage of .302.
• Including all qualifying hitters in the majors, he is 120th in batting average, 127th in on-base percentage and 32nd in slugging percentage.
• Taylor Ward has a .388 OBP while slugging .438. Both pace his team. He has a batting average of .301.
• Including all qualifying hitters, he is 32nd in batting average, 23rd in on-base percentage and 68th in slugging percentage.
• Jeremiah Jackson has two doubles and four home runs while batting .340.
• Pete Alonso has four doubles, two home runs and 13 walks while hitting .197.

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