Guardians vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 26

Odds updated as of 12:12 a.m.

MLB action on Wednesday includes the Cleveland Guardians playing the Los Angeles Angels.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Guardians vs Angels Game Info

• Cleveland Guardians (66-66) vs. Los Angeles Angels (52-80)
• Date: Wednesday, August 26, 2026
• Time: 4:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: ABTV and CleGuardians.TV

Guardians vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-140) | LAA: (+130)
• Spread: CLE: -1.5 (+116) | LAA: +1.5 (-140)
• Total: 7 -- Over: (-112) | Under: (-108)

Guardians vs Angels Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 9-7, 3.73 ERA vs Grayson Rodriguez (Angels) - 4-5, 6.41 ERA

This contest's pitching matchup is set, as the Guardians will send Joey Cantillo (9-7) to the mound, while Grayson Rodriguez (4-5) will take the ball for the Angels. Cantillo and his team have a record of 17-10-0 against the spread when he starts. Cantillo's team has won 61.5% of his starts when they are favored on the moneyline (8-5). The Angels have gone 7-7-0 ATS in Rodriguez's 14 starts that had a set spread. The Angels have been the moneyline underdog in 13 of Rodriguez's starts this season, and they went 4-9 in those games.

Guardians vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.6%)

Guardians vs Angels Moneyline

• The moneyline numbers for Guardians vs. Angels reveal Cleveland as the favorite (-140) and Los Angeles as the underdog (+130) despite being the home team.

Guardians vs Angels Spread

• The Angels are +1.5 on the run line against the Guardians. The Angels are -140 to cover, and the Guardians are +116.

Guardians vs Angels Over/Under

• Guardians versus Angels on Aug. 26 has an over/under of 7 runs, with the odds on the over -112 and the under set at -108.

Bet on Cleveland Guardians vs. Los Angeles Angels on FanDuel today!

Guardians vs Angels Betting Trends

• The Guardians have been favorites in 74 games this season and have come away with the win 37 times (50%) in those contests.
• Cleveland has a record of 15-9 when favored by -140 or more this year.
• The Guardians and their opponents have gone over in 60 of their 126 games with a total set by sportsbooks this season.
• The Guardians are 61-65-0 against the spread in their 126 games that had a posted line this season.
• The Angels are 38-66 in games they were the underdog on the moneyline (winning 36.5% of those games).
• Los Angeles is 21-33 (winning just 38.9% of its games) when playing as a moneyline underdog of +130 or longer.
• The Angels have played in 131 games with an over/under set, and have combined with their opponents to go over the total 52 times (52-76-3).
• The Angels are 68-63-0 ATS this season.

Guardians Player Leaders

• Chase DeLauter has 119 hits to go with a slugging percentage of .450, both of which are best among Cleveland hitters this season. He has a .288 batting average and an on-base percentage of .363.
• Among the qualifying hitters in MLB, his batting average ranks 12th, his on-base percentage ranks 27th, and he is 45th in slugging.
• Jose Ramirez is batting .235 with 20 doubles, 10 home runs and 54 walks. He's slugging .374 with an on-base percentage of .334.
• He ranks 108th in batting average, 65th in on-base percentage and 114th in slugging in MLB.
• Ramirez has picked up a hit in two straight games. In his last five games he is hitting .143 with an RBI.
• Steven Kwan has 113 hits this season and a team-best OBP of .371.
• Kwan takes a two-game hitting streak into this game. During his last five outings he is batting .286 with five walks and two RBIs.
• Brayan Rocchio has 10 home runs, 53 RBI and a batting average of .247 this season.

Angels Player Leaders

• Mike Trout has accumulated a team-high .381 on-base percentage. He's batting .240 and slugging .433.
• Including all qualified hitters in the majors, he is 99th in batting average, eighth in on-base percentage and 61st in slugging percentage.
• Trout hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .222 with two doubles, four walks and an RBI.
• Zach Neto has collected 121 hits while slugging .434. Both lead his team. He has a batting average of .237 with an on-base percentage of .316.
• He is 106th in batting average, 98th in on-base percentage and 58th in slugging percentage in the majors.
• Vaughn Grissom is batting .245 with 18 doubles, seven home runs and 23 walks.
• Moises Ballesteros has nine doubles, six home runs and 22 walks while batting .214.

Guardians vs Angels Head to Head

• 8/24/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +150)
• 5/13/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/12/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/11/2026: 7-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/1/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 5/31/2025: 7-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/30/2025: 4-1 LAA (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/6/2025: 6-2 LAA (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/5/2025: 10-4 LAA (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/4/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!