Dodgers vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 9:11 p.m.

The MLB's Wednesday slate includes the Los Angeles Dodgers facing the Arizona Diamondbacks.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Dodgers vs Diamondbacks Game Info

• Los Angeles Dodgers (30-19) vs. Arizona Diamondbacks (26-23)
• Date: Wednesday, May 21, 2025
• Time: 10:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: SportsNet LA and ARID

Dodgers vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-142) | ARI: (+120)
• Spread: LAD: -1.5 (+140) | ARI: +1.5 (-170)
• Total: 9 -- Over: (-122) | Under: (-100)

Dodgers vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Dustin May (Dodgers) - 1-4, 4.43 ERA vs Corbin Burnes (Diamondbacks) - 3-1, 2.56 ERA

The probable pitchers are Dustin May (1-4) for the Dodgers and Corbin Burnes (3-1) for the Diamondbacks. May's team is 2-6-0 against the spread in his starts this season. May's team has a record of 3-4 this season when he starts and they are the favorite on the moneyline. When Burnes starts, the Diamondbacks have gone 3-5-0 against the spread. The Diamondbacks have always been the moneyline underdog when Burnes starts this season.

Dodgers vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (53.7%)

Dodgers vs Diamondbacks Moneyline

• The moneyline numbers for Dodgers vs. Diamondbacks reveal Los Angeles as the favorite (-142) and Arizona as the underdog (+120) on the road.

Dodgers vs Diamondbacks Spread

• The Dodgers are favored by 1.5 runs at home versus the Diamondbacks. The Dodgers are +140 to cover the spread, while the Diamondbacks are -170.

Dodgers vs Diamondbacks Over/Under

• Dodgers versus Diamondbacks on May 21 has an over/under of 9 runs, with the odds on the over -122 and the under set at -100.

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Dodgers vs Diamondbacks Betting Trends

• The Dodgers have won in 27, or 62.8%, of the 43 contests they have been named as odds-on favorites in this year.
• This year Los Angeles has won 23 of 35 games when listed as at least -142 on the moneyline.
• The Dodgers and their opponents have gone over the total this season in 27 of their 48 opportunities.
• The Dodgers have posted a record of 22-26-0 against the spread this season.
• The Diamondbacks have won eight of the 17 games they were the underdog on the moneyline this season (47.1%).
• Arizona has a 4-2 record (winning 66.7% of its games) when playing as a moneyline underdog of +120 or longer.
• The Diamondbacks have played in 48 games with an over/under set, and have combined with their opponents to go over the total 22 times (22-23-3).
• The Diamondbacks have a 23-25-0 record ATS this season (covering 47.9% of the time).

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles in slugging percentage (.668) thanks to 30 extra-base hits. He has a .311 batting average and an on-base percentage of .405.
• Among qualified hitters, he is 10th in batting average, his on-base percentage ranks sixth, and he is third in slugging.
• Ohtani has picked up at least one hit in three straight games. During his last five outings he is batting .318 with a double, two home runs, two walks and three RBIs.
• Mookie Betts is hitting .261 with five doubles, a triple, eight home runs and 23 walks. He's slugging .438 with an on-base percentage of .347.
• He ranks 72nd in batting average, 61st in on-base percentage and 66th in slugging among qualified hitters.
• Betts enters this game looking to extend his two-game hit streak. During his last five outings he is batting .200 with two home runs, three walks and two RBIs.
• Freddie Freeman has 52 hits and is batting .371 this season.
• Freeman has logged a hit or more in four games in a row. During his last five outings he is hitting .381 with three doubles and a walk.
• Teoscar Hernandez has nine home runs, 35 RBI and a batting average of .306 this season.

Diamondbacks Player Leaders

• Corbin Carroll has racked up a team-best slugging percentage (.597) and leads the Diamondbacks in hits (57). He's batting .277 and with an on-base percentage of .349.
• He ranks 50th in batting average, 59th in on-base percentage and fourth in slugging percentage among all qualified batters in the big leagues.
• Geraldo Perdomo paces his team with a .405 on-base percentage. He has a batting average of .307 while slugging .494.
• He ranks 13th in batting average, sixth in on-base percentage and 31st in slugging percentage in MLB.
• Josh Naylor is batting .291 with 12 doubles, five home runs and 19 walks.
• Eugenio Suarez has nine doubles, 14 home runs and 17 walks while hitting .213.

Dodgers vs Diamondbacks Head to Head

• 5/20/2025: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 5/19/2025: 9-5 ARI (Favorite: Dodgers, Spread: -1.5, Total: 10.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/11/2025: 8-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/10/2025: 3-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 14-11 LAD (Favorite: Diamondbacks, Spread: -1.5, Total: 10.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/8/2025: 5-3 ARI (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2024: 11-6 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/1/2024: 14-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2024: 8-6 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/30/2024: 10-9 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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