Dodgers vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 9:12 a.m.

The Wednesday slate in MLB includes a matchup between the Los Angeles Dodgers and the Arizona Diamondbacks.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Diamondbacks Game Info

• Los Angeles Dodgers (30-19) vs. Arizona Diamondbacks (26-23)
• Date: Wednesday, May 21, 2025
• Time: 10:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: SportsNet LA and ARID

Dodgers vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-138) | ARI: (+118)
• Spread: LAD: -1.5 (+138) | ARI: +1.5 (-166)
• Total: 9 -- Over: (-110) | Under: (-110)

Dodgers vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Dustin May (Dodgers) - 1-4, 4.43 ERA vs Corbin Burnes (Diamondbacks) - 3-1, 2.56 ERA

This contest's pitching matchup is set, as the Dodgers will send Dustin May (1-4) to the mound, while Corbin Burnes (3-1) will take the ball for the Diamondbacks. May and his team have a record of 2-6-0 against the spread when he starts. May's team has been victorious in 42.9% of the games he's started as the moneyline favorite with a record of 3-4. When Burnes starts, the Diamondbacks have gone 3-5-0 against the spread. The Diamondbacks have not been a moneyline underdog when Burnes starts this season.

Dodgers vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (53.7%)

Dodgers vs Diamondbacks Moneyline

• Los Angeles is the favorite, -138 on the moneyline, while Arizona is a +118 underdog on the road.

Dodgers vs Diamondbacks Spread

• The Diamondbacks are at the Dodgers, and are +1.5 on the runline. The Diamondbacks are +138 to cover the spread, and the Dodgers are -166.

Dodgers vs Diamondbacks Over/Under

• Dodgers versus Diamondbacks, on May 21, has an over/under of 9, with the over being -110 and the under -110.

Bet on Los Angeles Dodgers vs. Arizona Diamondbacks on FanDuel today!

Dodgers vs Diamondbacks Betting Trends

• The Dodgers have been victorious in 27, or 62.8%, of the 43 contests they have been chosen as favorites in this season.
• Los Angeles has a record of 24-12 in contests when bookmakers favor them by -138 or more on the moneyline.
• The Dodgers and their opponents have gone over in 27 of their 48 games with a total set by sportsbooks this season.
• In 48 games with a line this season, the Dodgers have a mark of 22-26-0 against the spread.
• The Diamondbacks are 8-9 in games they were the underdog on the moneyline (winning 47.1% of those games).
• Arizona has a 5-3 record (winning 62.5% of its games) when playing as a moneyline underdog of +118 or longer.
• In the 48 games oddsmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 22 times (22-23-3).
• The Diamondbacks have put together a 23-25-0 record against the spread this season.

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles in slugging percentage (.668) thanks to 30 extra-base hits. He has a .311 batting average and an on-base percentage of .405.
• Among qualifying hitters in the majors, he ranks eighth in batting average, sixth in on-base percentage, and third in slugging.
• Ohtani hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .318 with a double, two home runs, two walks and three RBIs.
• Mookie Betts has five doubles, a triple, eight home runs and 23 walks. He's batting .261 and slugging .438 with an on-base percentage of .347.
• He is 75th in batting average, 61st in on-base percentage and 68th in slugging in MLB.
• Betts heads into this game looking to extend his two-game hit streak. In his last five games he is batting .200 with two home runs, three walks and two RBIs.
• Freddie Freeman leads Los Angeles with 52 hits. He is batting .371 this season and 23 of his hits have gone for extra bases.
• Freeman takes a four-game hitting streak into this game. In his last five games he is hitting .381 with three doubles and a walk.
• Teoscar Hernandez is batting .306 with a .329 OBP and 35 RBI for Los Angeles this season.

Diamondbacks Player Leaders

• Corbin Carroll has racked up a slugging percentage of .597 and has 57 hits, both team-best numbers for the Diamondbacks. He's batting .277 and with an on-base percentage of .349.
• Including all qualified players in the majors, he ranks 52nd in batting average, 60th in on-base percentage and fourth in slugging percentage.
• Geraldo Perdomo paces his team with a .405 on-base percentage. He has a batting average of .307 while slugging .494.
• His batting average is 14th among all qualified players, his on-base percentage is sixth, and he is 29th in slugging.
• Josh Naylor has 12 doubles, five home runs and 19 walks while batting .291.
• Eugenio Suarez has nine doubles, 14 home runs and 17 walks while hitting .213.

Dodgers vs Diamondbacks Head to Head

• 5/20/2025: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 5/19/2025: 9-5 ARI (Favorite: Dodgers, Spread: -1.5, Total: 10.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/11/2025: 8-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/10/2025: 3-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 14-11 LAD (Favorite: Diamondbacks, Spread: -1.5, Total: 10.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/8/2025: 5-3 ARI (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2024: 11-6 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/1/2024: 14-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2024: 8-6 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/30/2024: 10-9 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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