Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 6:11 p.m.

The Friday slate in MLB includes a matchup between the Chicago Cubs and the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Reds Game Info

• Chicago Cubs (30-20) vs. Cincinnati Reds (25-26)
• Date: Friday, May 23, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-116) | CIN: (-102)
• Spread: CHC: -1.5 (+142) | CIN: +1.5 (-172)
• Total: 8 -- Over: (-122) | Under: (-100)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 4-2, 2.98 ERA vs Hunter Greene (Reds) - 4-2, 2.36 ERA

The Cubs will look to Matthew Boyd (4-2) versus the Reds and Hunter Greene (4-2). Boyd and his team are 3-6-0 ATS this season when he starts. Boyd's team has won 80% of his starts when they are favored on the moneyline (4-1). When Greene starts, the Reds have gone 3-4-0 against the spread. The Reds have been the underdog on the moneyline in four of Greene's starts this season, and they went 2-2 in those games.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (51.8%)

Cubs vs Reds Moneyline

• The moneyline numbers for Cubs vs. Reds reveal Chicago as the favorite (-116) and Cincinnati as the underdog (-102) despite being the home team.

Cubs vs Reds Spread

• The Cubs are favored by 1.5 runs on the road versus the Reds. The Cubs are +142 to cover the spread, while the Reds are -172.

Cubs vs Reds Over/Under

• A total of 8 runs has been set for the Cubs-Reds contest on May 23, with the over available at -122 and the under at -100.

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Cubs vs Reds Betting Trends

• The Cubs have come away with 20 wins in the 28 contests they have been listed as the favorites in this season.
• This year Chicago has won 19 of 27 games when listed as at least -116 on the moneyline.
• The Cubs' games have gone over the total in 30 of their 48 opportunities.
• The Cubs have posted a record of 25-23-0 against the spread this season.
• The Reds have gone 12-14 in games they were the underdog on the moneyline (winning 46.2% of those games).
• Cincinnati is 10-12 (winning 45.5% of its games) when playing as a moneyline underdog of -102 or longer.
• In the 49 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 18 times (18-29-2).
• The Reds have collected a 26-23-0 record against the spread this season (covering 53.1% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .387 this season while batting .278 with 35 walks and 38 runs scored. He has a slugging percentage of .552.
• Among all qualifying batters in MLB, he ranks 47th in batting average, 15th in on-base percentage, and 13th in slugging.
• Tucker has hit safely in two straight games. During his last five outings he is hitting .389 with two home runs, five walks and two RBIs.
• Pete Crow-Armstrong has 55 hits to go with a slugging percentage of .553, both of which are tops among Chicago hitters this season. He's batting .279 with an on-base percentage of .313.
• He is 44th in batting average, 103rd in on-base percentage and 11th in slugging in the major leagues.
• Seiya Suzuki has collected 47 base hits, an OBP of .309 and a slugging percentage of .527 this season.
• Suzuki takes a three-game hitting streak into this game. During his last five outings he is hitting .316 with two doubles, a home run, three walks and six RBIs.
• Dansby Swanson has been key for Chicago with 50 hits, an OBP of .319 plus a slugging percentage of .466.
• Swanson takes a seven-game hitting streak into this game. In his last 10 outings he is batting .351 with two home runs, four walks and five RBIs.

Reds Player Leaders

• Elly De La Cruz is batting .242 with eight doubles, eight home runs and 20 walks. He's slugging .404 with an on-base percentage of .317.
• Including all the qualifying hitters in the big leagues, his batting average is 102nd, his on-base percentage ranks 97th, and he is 92nd in slugging.
• TJ Friedl is slugging .391 to pace his team. He has a batting average of .274 with an on-base percentage of .359.
• His batting average is 58th among all qualified players, his on-base percentage is 43rd, and he is 105th in slugging.
• Gavin Lux has put up an on-base percentage of .377 and has 45 hits, both team-best numbers for the Reds.
• Austin Hays is hitting .316 with six doubles, six home runs and seven walks.

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