Cubs vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 11:11 p.m.

The MLB schedule on Friday includes the Chicago Cubs facing the Washington Nationals.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Nationals Game Info

• Chicago Cubs (80-60) vs. Washington Nationals (56-83)
• Date: Friday, September 5, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: Apple TV+

Cubs vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-235) | WSH: (+194)
• Spread: CHC: -1.5 (-118) | WSH: +1.5 (-102)
• Total: 10.5 -- Over: (-100) | Under: (-122)

Cubs vs Nationals Probable Starting Pitchers

Probable Pitchers: Javier Assad (Cubs) - 1-1, 4.05 ERA vs Jake Irvin (Nationals) - 8-10, 5.42 ERA

The Cubs will call on Javier Assad (1-1) versus the Nationals and Jake Irvin (8-10). Assad's team has not covered in any of his four starts with a spread this season. Assad's team has won each of the three games he's started as the moneyline favorite. The Nationals are 15-12-0 against the spread when Irvin starts. The Nationals are 13-13 in Irvin's 26 starts this season that they were the moneyline underdog.

Cubs vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (70.1%)

Cubs vs Nationals Moneyline

• Chicago is a -235 favorite on the moneyline, while Washington is a +194 underdog on the road.

Cubs vs Nationals Spread

• The Nationals are at the Cubs, and are +1.5 on the runline. The Nationals are -118 to cover the spread, and the Cubs are -102.

Cubs vs Nationals Over/Under

• The over/under for the Cubs versus Nationals contest on Sept. 5 has been set at 10.5, with -100 odds on the over and -122 odds on the under.

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Cubs vs Nationals Betting Trends

• The Cubs have been victorious in 61, or 64.2%, of the 95 contests they have been chosen as favorites in this season.
• This year Chicago has won 10 of 11 games when listed as at least -235 on the moneyline.
• Contests with the Cubs have gone over the total set by oddsmakers in 63 of 136 chances this season.
• In 136 games with a line this season, the Cubs have a mark of 62-74-0 against the spread.
• The Nationals have won 48 of the 112 games they were the moneyline underdog this season (42.9%).
• When it has played as a moneyline underdog with odds of +194 or longer, Washington has a 3-9 record (winning just 25% of its games).
• The Nationals have combined with opponents to go over the total 70 times this season for a 70-56-7 record against the over/under.
• The Nationals have collected a 66-67-0 record against the spread this season (covering 49.6% of the time).

Cubs Player Leaders

• Kyle Tucker has 132 hits this season and a team-best OBP of .381. He has a .270 batting average and a slugging percentage of .472.
• Among qualifying batters in MLB, he is 45th in batting average, eighth in on-base percentage, and 40th in slugging.
• Pete Crow-Armstrong leads Chicago with 130 hits. He is batting .250 this season and has 66 extra-base hits. He's also slugging .493 with an on-base percentage of .290.
• Among qualifying batters, his batting average ranks him 95th, his on-base percentage 142nd, and his slugging percentage 24th.
• Nico Hoerner has hit five homers with a team-high .377 SLG this season.
• Seiya Suzuki has 27 home runs, 89 RBI and a batting average of .244 this season.

Nationals Player Leaders

• C.J. Abrams is hitting .265 with 29 doubles, five triples, 17 home runs and 34 walks. He's slugging .447 with an on-base percentage of .328.
• He is 59th in batting average, 82nd in on-base percentage and 70th in slugging percentage among all qualified hitters in the big leagues.
• James Wood's 134 hits, .355 on-base percentage and .474 slugging percentage are all team-highs. He has a batting average of .258.
• His batting average is 84th among all qualified players, his on-base percentage ranks 32nd, and he is 39th in slugging.
• Luis Garcia has 26 doubles, a triple, 11 home runs and 23 walks while hitting .260.
• Josh Bell is batting .224 with 12 doubles, a triple, 16 home runs and 53 walks.

Cubs vs Nationals Head to Head

• 6/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/4/2025: 2-0 WSH (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/3/2025: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/21/2024: 5-1 WSH (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/20/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/19/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/1/2024: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/31/2024: 5-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/30/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/19/2023: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)

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