Cubs vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for March 28

Odds updated as of 10:12 p.m.

The MLB slate on Saturday includes the Chicago Cubs taking on the Washington Nationals.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Nationals Game Info

• Chicago Cubs (0-1) vs. Washington Nationals (1-0)
• Date: Saturday, March 28, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Nationals.TV

Cubs vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-230) | WSH: (+190)
• Spread: CHC: -1.5 (-111) | WSH: +1.5 (-108)
• Total: 9.5 -- Over: (-102) | Under: (-120)

Cubs vs Nationals Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 0-0, 0.00 ERA vs Miles Mikolas (Nationals) - 0-0, 0.00 ERA

The Cubs will give the nod to Cade Horton against the Nationals and Miles Mikolas. In games Horton pitched with a spread last season, his team was 11-11-0 ATS. Horton and his team were 12-4 when he pitched and they were the moneyline favorite. Last season when Mikolas pitched his team finished 14-17-0 against the spread. Mikolas and his team had a 9-14 record in games he pitched when they were moneyline underdogs a season ago.

Cubs vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (72.4%)

Cubs vs Nationals Moneyline

• Washington is the underdog, +190 on the moneyline, while Chicago is a -230 favorite at home.

Cubs vs Nationals Spread

• The Cubs are favored by 1.5 runs at home versus the Nationals. The Cubs are -111 to cover the spread, while the Nationals are -108.

Cubs vs Nationals Over/Under

• An over/under of 9.5 has been set for Cubs-Nationals on March 28, with the over being -102 and the under -120.

Bet on Chicago Cubs vs. Washington Nationals on FanDuel today!

Cubs vs Nationals Betting Trends

• The Cubs came away with 72 wins in the 111 contests they were listed as the favorites last season.
• Last season Chicago came away with a win 11 times in 14 chances when named as a favorite of at least -230 or shorter on the moneyline.
• The Cubs and their opponents hit the over in 77 of their 165 games with a total last season.
• The Nationals finished 56-75 in games they were the underdog on the moneyline last season (winning 42.7% of those games).
• When it played as a moneyline underdog with odds of +190 or longer last year, Washington went 6-12 (33.3%).
• The Nationals combined with their opponents to go over the total 83 times last season for an 83-66-7 record against the over/under.

Cubs Player Leaders

• Nico Hoerner finished with an OPS of .739 last season, fueled by a .345 OBP and a slugging percentage of .394.
• Pete Crow-Armstrong slashed .247/.287/.481 and finished with an OPS of .768.
• Last season, Michael Busch had 137 base hits, batting .261 with 64 extra-base hits.
• Ian Happ slashed .243/.342/.420 and finished with an OPS of .762.

Nationals Player Leaders

• C.J. Abrams had 35 doubles, five triples, 19 home runs and 37 walks while batting .257 last season.
• James Wood put together 153 hits and a .350 on-base percentage while slugging .475.
• Luis Garcia hit .252 with 28 doubles, a triple, 16 home runs and 27 walks a season ago.
• Daylen Lile hit .299 with 15 doubles, 11 triples, nine home runs and 21 walks.

Cubs vs Nationals Head to Head

• 3/26/2026: 10-4 WSH (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/7/2025: 6-3 WSH (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/6/2025: 2-1 WSH (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 9/5/2025: 11-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/4/2025: 2-0 WSH (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/3/2025: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/21/2024: 5-1 WSH (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/20/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/19/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!