Cubs vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for March 26

Odds updated as of 2:12 p.m.

The Chicago Cubs and the Washington Nationals meet for MLB Opening Day on Thursday.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Nationals Game Info

• Chicago Cubs (0-0) vs. Washington Nationals (0-0)
• Date: Thursday, March 26, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Nationals.TV

Cubs vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-210) | WSH: (+176)
• Spread: CHC: -1.5 (+118) | WSH: +1.5 (-142)
• Total: 7 -- Over: (-110) | Under: (-110)

Cubs vs Nationals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 0-0, 0.00 ERA vs Cade Cavalli (Nationals) - 0-0, 0.00 ERA

The Cubs will give the nod to Matthew Boyd versus the Nationals and Cade Cavalli. In 34 games he pitched with a spread last season, Boyd and his team finished with a 16-18-0 record ATS. Boyd and his team had a 16-10 record when he pitched as a favorite last season. Last season Cavalli and his team went 7-3-0 against the spread when he pitched. Cavalli's team went 6-2 in games he appeared in when they were moneyline underdogs a season ago.

Cubs vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (71%)

Cubs vs Nationals Moneyline

• The moneyline numbers for Cubs vs. Nationals reveal Chicago as the favorite (-210) and Washington as the underdog (+176) on the road.

Cubs vs Nationals Spread

• The Nationals are +1.5 on the run line against the Cubs. The Nationals are -142 to cover, and the Cubs are +118.

Cubs vs Nationals Over/Under

• A combined run total of 7 has been set for Cubs-Nationals on March 26, with the over at -110 and the under at -110.

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Cubs vs Nationals Betting Trends

• The Cubs came away with 72 wins in the 111 contests they were listed as the favorites last season.
• Last season Chicago came away with a win 13 times in 17 chances when named as a favorite of at least -210 or shorter on the moneyline.
• The Cubs and their opponents hit the over in 77 of their 165 games with a total last season.
• The Nationals won 56 of the 131 games they were the underdog on the moneyline last season (42.7%).
• In games it played as a moneyline underdog with odds of +176 or longer last year, Washington went 8-15 (34.8%).
• The Nationals played in 156 games with a set over/under last season, and combined with their opponents to go over the total 83 times (83-66-7).

Cubs Player Leaders

• Nico Hoerner had an OBP of .345 to go with a slugging percentage of .394 last season.
• Pete Crow-Armstrong slashed .247/.287/.481 and finished with an OPS of .768.
• Last season, Michael Busch had 137 base hits, batting .261 with 64 extra-base hits.
• Ian Happ slashed .243/.342/.420 and finished with an OPS of .762.

Nationals Player Leaders

• C.J. Abrams had 35 doubles, five triples, 19 home runs and 37 walks while batting .257 last season.
• James Wood put up 153 hits and a .350 OBP while slugging .475.
• Luis Garcia hit .252 with 28 doubles, a triple, 16 home runs and 27 walks a season ago.
• Daylen Lile hit .299 with 15 doubles, 11 triples, nine home runs and 21 walks.

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