Cubs vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for March 26

Odds updated as of 10:12 p.m.

MLB Opening Day on Thursday features the Chicago Cubs facing the Washington Nationals.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Nationals Game Info

• Chicago Cubs (0-0) vs. Washington Nationals (0-0)
• Date: Thursday, March 26, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and NATS

Cubs vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-220) | WSH: (+184)
• Spread: CHC: -1.5 (-104) | WSH: +1.5 (-115)
• Total: 8 -- Over: (-105) | Under: (-115)

Cubs vs Nationals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 0-0, 0.00 ERA vs Cade Cavalli (Nationals) - 0-0, 0.00 ERA

The Cubs will look to Matthew Boyd against the Nationals and Cade Cavalli. Boyd and his team were 16-18-0 ATS in games he pitched last year. Boyd appeared in 26 games last season as the moneyline favorite and his team finished with a record of 16-10 in those contests. Last season in games Cavalli pitched his team went 7-3-0 against the spread. Cavalli's team went 6-2 in games he appeared in when they were the moneyline underdog a season ago.

Cubs vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (71%)

Cubs vs Nationals Moneyline

• Chicago is a -220 favorite on the moneyline, while Washington is a +184 underdog on the road.

Cubs vs Nationals Spread

• The Cubs are favored by 1.5 runs at home against the Nationals. The Cubs are -104 to cover the spread, while the Nationals are -115.

Cubs vs Nationals Over/Under

• The over/under for Cubs-Nationals on March 26 is 8. The over is -105, and the under is -115.

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Cubs vs Nationals Betting Trends

• The Cubs were chosen as favorites in 111 games last year and walked away with the win 72 times (64.9%) in those games.
• Last season Chicago came away with a win 12 times in 15 chances when named as a favorite of at least -220 or shorter on the moneyline.
• The Cubs and their opponents hit the over in 77 of their 165 games with a total last season.
• The Nationals won 56 of the 131 games they were the underdog on the moneyline last season (42.7%).
• In games it played as a moneyline underdog with odds of +184 or longer last year, Washington went 7-12 (36.8%).
• The Nationals combined with their opponents to hit the over on the total 83 times last season for an 83-66-7 record against the over/under.

Cubs Player Leaders

• Nico Hoerner had an OBP of .345 to go with a slugging percentage of .394 last season.
• Pete Crow-Armstrong slashed .247/.287/.481 and finished with an OPS of .768.
• Michael Busch finished last season with 137 hits while batting .261.
• Ian Happ slashed .243/.342/.420 and finished with an OPS of .762.

Nationals Player Leaders

• C.J. Abrams had 35 doubles, five triples, 19 home runs and 37 walks while hitting .257 last season.
• James Wood put together 153 hits and a .350 OBP while slugging .475.
• Luis Garcia hit .252 with 28 doubles, a triple, 16 home runs and 27 walks a season ago.
• Daylen Lile hit .299 with 15 doubles, 11 triples, nine home runs and 21 walks.

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