Cubs vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 5

Odds updated as of 12:12 a.m.

Sunday's slate in the MLB includes a matchup between the Chicago Cubs and the Cleveland Guardians.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Guardians Game Info

• Chicago Cubs (3-4) vs. Cleveland Guardians (5-3)
• Date: Sunday, April 5, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MARQ

Cubs vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-144) | CLE: (+122)
• Spread: CHC: -1.5 (+116) | CLE: +1.5 (-140)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Cubs vs Guardians Probable Starting Pitchers

Probable Pitchers: Edward Cabrera (Cubs) - 1-0, 0.00 ERA vs Slade Cecconi (Guardians) - 0-1, 12.46 ERA

The Cubs will call on Edward Cabrera (1-0) against the Guardians and Slade Cecconi (0-1). Cabrera helped his team cover the spread in his only opportunity this season as a starter. Cabrera's team won his only start as a favorite this season. Cecconi has started only one game with a set spread, which the Guardians failed to cover. The Guardians were the underdog on the moneyline for one Cecconi start this season -- they lost.

Cubs vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (50.7%)

Cubs vs Guardians Moneyline

• Chicago is the favorite, -144 on the moneyline, while Cleveland is a +122 underdog despite being at home.

Cubs vs Guardians Spread

• The Cubs are favored by 1.5 runs on the road versus the Guardians. The Cubs are +116 to cover the spread, while the Guardians are -140.

Cubs vs Guardians Over/Under

• An over/under of 7.5 has been set for Cubs-Guardians on April 5, with the over being -115 and the under -105.

Bet on Chicago Cubs vs. Cleveland Guardians on FanDuel today!

Cubs vs Guardians Betting Trends

• The Cubs have been favorites in seven games this season and have come away with the win three times (42.9%) in those contests.
• Chicago has a record of 3-2 in contests when bookmakers favor them by -144 or more on the moneyline.
• The Cubs' games have gone over the total in three of their seven opportunities.
• The Cubs are 3-4-0 against the spread in their seven games with a line set by sportsbooks this season.
• The Guardians have put together a 5-3 record in games they were listed as the moneyline underdog (winning 62.5% of those games).
• Cleveland has a 4-2 record (winning 66.7% of its games) when it has played as a moneyline underdog of +122 or longer.
• The Guardians have played in eight games with a set over/under, and have combined with opponents to go over the total three times (3-5-0).
• The Guardians have collected a 5-3-0 record against the spread this season (covering 62.5% of the time).

Cubs Player Leaders

• Nico Hoerner has an OPS of .858, fueled by an OBP of .400 to go with a slugging percentage of .458. He has a .292 batting average, as well.
• Among qualified hitters in MLB, he ranks 53rd in batting average, 36th in on-base percentage, and 61st in slugging.
• Alex Bregman is hitting .214 with two home runs and four walks, while slugging .429 with an on-base percentage of .313.
• Among qualifying hitters, his batting average places him 124th, his on-base percentage 113th, and his slugging percentage 77th.
• Bregman has picked up a hit in two straight games. During his last five outings he is hitting .263 with two home runs, three walks and three RBIs.
• Ian Happ leads Chicago with five hits. He is batting .179 this season and four of his hits have gone for extra bases.
• Michael Busch is batting .240 with a .367 OBP and one RBI for Chicago this season.

Guardians Player Leaders

• Chase DeLauter has accumulated a team-best OBP (.370) and slugging percentage (.923), and paces the Guardians in hits (nine, while batting .346).
• Including all the qualified hitters in MLB, he ranks 18th in batting average, 59th in on-base percentage and first in slugging percentage.
• Jose Ramirez has two doubles, a home run and two walks while hitting .188. He's slugging .344 with an on-base percentage of .235.
• Including all qualified players, his batting average places him 148th, his on-base percentage ranks 173rd, and he is 117th in slugging.
• Steven Kwan has a double and four walks while batting .233.
• Brayan Rocchio has a .370 OBP to lead his team.

Cubs vs Guardians Head to Head

• 4/3/2026: 4-1 CLE (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/3/2025: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 7/2/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/1/2025: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/13/2024: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/12/2024: 9-8 CLE (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/30/2023: 10-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!