Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 31

Odds updated as of 7:12 p.m.

The St. Louis Cardinals will face the Chicago Cubs in MLB action on Sunday.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Cubs Game Info

• St. Louis Cardinals (30-26) vs. Chicago Cubs (32-27)
• Date: Sunday, May 31, 2026
• Time: 7:20 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: NBC/Peacock

Cardinals vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-120) | CHC: (+102)
• Spread: STL: -1.5 (+168) | CHC: +1.5 (-205)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Cardinals vs Cubs Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 2-3, 4.76 ERA vs Jordan Wicks (Cubs) - 0-1, 16.62 ERA

The probable starters are Matthew Liberatore (2-3) for the Cardinals and Jordan Wicks (0-1) for the Cubs. Liberatore's team is 6-5-0 against the spread this season in his starts. Liberatore's team won his only start as a favorite this season. Wicks has started just one game with a set spread, which the Cubs failed to cover. The Cubs were the underdog on the moneyline for one Wicks start this season -- they lost.

Cardinals vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (57.6%)

Cardinals vs Cubs Moneyline

• The moneyline numbers for Cardinals vs. Cubs reveal St. Louis as the favorite (-120) and Chicago as the underdog (+102) on the road.

Cardinals vs Cubs Spread

• The Cardinals are hosting the Cubs and are favored by 1.5 runs (+168 to cover) on the runline. Chicago is -205 to cover.

Cardinals vs Cubs Over/Under

• The over/under for the Cardinals versus Cubs game on May 31 has been set at 8.5, with -110 odds on the over and -110 odds on the under.

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Cardinals vs Cubs Betting Trends

• The Cardinals have won in four of the nine contests they have been named as odds-on favorites in this year.
• St. Louis has been listed as a favorite of -120 or more on two occasions this season and split those games.
• The Cardinals and their opponents have hit the over in 23 of their 55 games with a total set by oddsmakers this season.
• The Cardinals are 32-23-0 against the spread in their 55 games that had a posted line this season.
• The Cubs have been the moneyline underdog 19 total times this season. They've finished 10-9 in those games.
• Chicago has a record of 6-6 when it has played as a moneyline underdog with odds of +102 or longer (50%).
• The Cubs have played in 58 games with a set over/under, and have combined with opponents to go over the total 33 times (33-25-0).
• The Cubs have collected a 24-34-0 record against the spread this season (covering 41.4% of the time).

Cardinals Player Leaders

• Jordan Walker has 61 hits to go with a slugging percentage of .557, both of which rank first among St. Louis hitters this season. He has a .290 batting average and an on-base percentage of .359.
• He is 23rd in batting average, 40th in on-base percentage, and sixth in slugging among qualified hitters in the majors.
• Alec Burleson has 13 doubles, seven home runs and 21 walks. He's batting .280 and slugging .439 with an on-base percentage of .347.
• He is 37th in batting average, 56th in on-base percentage and 57th in slugging among qualifying hitters.
• Ivan Herrera leads St. Louis with an OBP of .386 this season while batting .260 with 33 walks and 33 runs scored.
• JJ Wetherholt has nine home runs, 25 RBI and a batting average of .244 this season.
• Wetherholt enters this matchup on a three-game hitting streak. During his last five outings he is batting .316 with two doubles and a walk.

Cubs Player Leaders

• Nico Hoerner is hitting .252 with 13 doubles, four home runs and 27 walks. He's slugging .359 with an on-base percentage of .336.
• Including all the qualified players in the big leagues, his batting average places him 79th, his on-base percentage is 75th, and he is 119th in slugging.
• Ian Happ has collected 49 hits to lead his team. He has a batting average of .234 while slugging .478 with an on-base percentage of .355.
• Including all qualifying hitters, he ranks 109th in batting average, 47th in on-base percentage and 35th in slugging percentage.
• Michael Busch a has .368 on-base percentage to lead the Cubs.
• Pete Crow-Armstrong is hitting .237 with eight doubles, two triples, seven home runs and 22 walks.

Cardinals vs Cubs Head to Head

• 5/30/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2026: 6-5 STL (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/28/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/27/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)

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