Cardinals vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for May 15

Odds updated as of 8:11 p.m.

The Friday slate in MLB includes a matchup between the St. Louis Cardinals and the Kansas City Royals.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Royals Game Info

• St. Louis Cardinals (25-18) vs. Kansas City Royals (19-25)
• Date: Friday, May 15, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Royals.TV

Cardinals vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | KC: (-106)
• Spread: STL: +1.5 (-188) | KC: -1.5 (+155)
• Total: 8.5 -- Over: (-112) | Under: (-108)

Cardinals vs Royals Probable Starting Pitchers

Probable Pitchers: Dustin May (Cardinals) - 3-4, 4.85 ERA vs Michael Wacha (Royals) - 4-2, 2.63 ERA

The probable pitchers are Dustin May (3-4) for the Cardinals and Michael Wacha (4-2) for the Royals. May and his team are 4-4-0 ATS this season when he starts. May's team won his only start as a favorite this season. The Royals have a 4-4-0 record against the spread in Wacha's starts. The Royals are 1-3 in Wacha's four starts this season that they were the underdog on the moneyline.

Cardinals vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (52.5%)

Cardinals vs Royals Moneyline

• St. Louis is the favorite, -110 on the moneyline, while Kansas City is a -106 underdog on the road.

Cardinals vs Royals Spread

• The Royals are 1.5-run favorites against the spread for this matchup with the Cardinals. The Royals are +155 to cover, while the Cardinals are -188 to cover as a 1.5-run underdog on the runline.

Cardinals vs Royals Over/Under

• Cardinals versus Royals on May 15 has an over/under of 8.5 runs, with the odds on the over -112 and the under set at -108.

Bet on St. Louis Cardinals vs. Kansas City Royals on FanDuel today!

Cardinals vs Royals Betting Trends

• The Cardinals have been favorites in four games this season and have come away with the win two times (50%) in those contests.
• St. Louis has a record of 2-2 when favored by -110 or more this year.
• The Cardinals and their opponents have hit the over in 18 of their 43 games with a total set by oddsmakers this season.
• The Cardinals have an against the spread mark of 27-16-0 in 43 games with a line this season.
• The Royals have won 38.9% of the games this season they were the underdog on the moneyline (7-11).
• Kansas City is 7-11 (winning just 38.9% of its games) when playing as a moneyline underdog of -106 or longer.
• The Royals have had an over/under set by oddsmakers 42 times, and have combined with opponents to go over the total in 19 of those games (19-23-0).
• The Royals have put together an 18-24-0 record ATS this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis with 47 hits and a team-best slugging percentage of .575. He's batting .294 with an on-base percentage of .370.
• Among all qualifying batters in MLB, his batting average ranks 25th, his on-base percentage ranks 36th, and he is ninth in slugging.
• JJ Wetherholt is batting .244 with five doubles, eight home runs and 22 walks, while slugging .421 with an on-base percentage of .364.
• Among qualifying batters, he is 97th in batting average, 42nd in on-base percentage and 68th in slugging percentage.
• Alec Burleson has collected 45 base hits, an OBP of .342 and a slugging percentage of .448 this season.
• Ivan Herrera has 42 hits this season and a team-best OBP of .396.
• Herrera enters this game on a three-game hitting streak. During his last five outings he is hitting .273 with a double and three RBIs.

Royals Player Leaders

• Bobby Witt Jr. has totaled 53 hits with a .381 on-base percentage and a .503 slugging percentage, all club-highs for the Royals. He's batting .306.
• Including all the qualifying hitters in MLB, he ranks 14th in batting average, 22nd in on-base percentage and 25th in slugging percentage.
• Witt enters this game on a seven-game hitting streak. During his last 10 games he is hitting .395 with two doubles, five home runs, five walks and seven RBIs.
• Maikel Garcia is batting .274 with 12 doubles, a triple, three home runs and 19 walks. He's slugging .415 with an on-base percentage of .346.
• His batting average ranks 46th among all qualified players, his on-base percentage ranks 61st, and he is 73rd in slugging.
• Vinnie Pasquantino is hitting .204 with four doubles, two triples, five home runs and 18 walks.
• Carter Jensen has four doubles, six home runs and 17 walks while hitting .234.

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