Cardinals vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 26

Odds updated as of 7:12 p.m.

The Tuesday slate in MLB includes a matchup between the St. Louis Cardinals and the Pittsburgh Pirates.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Pirates Game Info

• St. Louis Cardinals (65-67) vs. Pittsburgh Pirates (57-75)
• Date: Tuesday, August 26, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SportsNet PT

Cardinals vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-126) | PIT: (+108)
• Spread: STL: -1.5 (+168) | PIT: +1.5 (-205)
• Total: 8 -- Over: (-114) | Under: (-106)

Cardinals vs Pirates Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 6-11, 5.17 ERA vs Mitch Keller (Pirates) - 5-12, 4.34 ERA

This contest's pitching matchup is set, as the Cardinals will send Andre Pallante (6-11) to the mound, while Mitch Keller (5-12) will take the ball for the Pirates. Pallante's team is 13-12-0 against the spread in his starts this season. When Pallante starts a game and his team is the favorite on the moneyline, they have a record of 4-5. The Pirates have a 15-10-0 ATS record in Keller's 25 starts that had a set spread. The Pirates are 8-11 in Keller's 19 starts this season that they were the underdog on the moneyline.

Cardinals vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (57%)

Cardinals vs Pirates Moneyline

• Pittsburgh is the underdog, +108 on the moneyline, while St. Louis is a -126 favorite at home.

Cardinals vs Pirates Spread

• The Pirates are +1.5 on the spread (-205 to cover), and St. Louis is +168 to cover the runline.

Cardinals vs Pirates Over/Under

• A total of 8 runs has been set for the Cardinals-Pirates game on Aug. 26, with the over available at -114 and the under at -106.

Bet on St. Louis Cardinals vs. Pittsburgh Pirates on FanDuel today!

Cardinals vs Pirates Betting Trends

• The Cardinals have been victorious in 29, or 51.8%, of the 56 contests they have been chosen as favorites in this season.
• This season St. Louis has been victorious 21 times in 37 chances when named as a favorite of at least -126 on the moneyline.
• The Cardinals and their opponents have hit the over in 66 of their 126 games with a total set by oddsmakers this season.
• The Cardinals have posted a record of 64-62-0 against the spread this season.
• The Pirates have been the underdog on the moneyline 84 total times this season. They've gone 34-50 in those games.
• In games it has played as a moneyline underdog with odds of +108 or longer, Pittsburgh has a record of 25-44 (36.2%).
• The Pirates have played in 124 games with a set over/under, and have combined with their opponents to go over the total 49 times (49-69-6).
• The Pirates have a 67-57-0 record ATS this season (covering 54% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis in slugging percentage (.461) and total hits (122) this season. He's batting .291 with an on-base percentage of .341.
• Among qualified hitters, he is 15th in batting average, his on-base percentage ranks 53rd, and he is 53rd in slugging.
• Burleson has picked up at least one hit in three straight games. During his last five outings he is batting .348 with two doubles, a home run and three RBIs.
• Willson Contreras is hitting .261 with 30 doubles, 19 home runs and 40 walks, while slugging .458 with an on-base percentage of .344.
• Among qualified hitters, he is 71st in batting average, 51st in on-base percentage and 56th in slugging percentage.
• Masyn Winn has 116 hits this season and has a slash line of .258/.313/.376.
• Lars Nootbaar is batting .236 with a .327 OBP and 44 RBI for St. Louis this season.

Pirates Player Leaders

• Bryan Reynolds has a slugging percentage of .410 and has 120 hits, both team-high numbers for the Pirates. He's batting .246 and with an on-base percentage of .305.
• Including all qualified hitters in MLB, he is 108th in batting average, 121st in on-base percentage and 95th in slugging percentage.
• Oneil Cruz is hitting .207 with 17 doubles, two triples, 18 home runs and 54 walks. He's slugging .398 with an on-base percentage of .304.
• He is currently 155th in batting average, 126th in on-base percentage and 111th in slugging percentage among all qualified hitters.
• Andrew McCutchen a has .331 on-base percentage to lead the Pirates.
• Isiah Kiner-Falefa has 19 doubles, two triples, a home run and 17 walks while batting .264.

Cardinals vs Pirates Head to Head

• 8/25/2025: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/2/2025: 5-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/1/2025: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/7/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 5/6/2025: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/7/2025: 8-4 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/19/2024: 3-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)

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