Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 2:11 p.m.

The Sunday slate in MLB includes a matchup between the St. Louis Cardinals and the Cleveland Guardians.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (78-77) vs. Cleveland Guardians (90-66)
• Date: Sunday, September 22, 2024
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: BSGL

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-124) | CLE: (+106)
• Spread: STL: -1.5 (+162) | CLE: +1.5 (-196)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 7-8, 3.87 ERA vs Gavin Williams (Guardians) - 3-10, 5.12 ERA

This contest's pitching matchup is set, as the Cardinals will send Andre Pallante (7-8) to the mound, while Gavin Williams (3-10) will take the ball for the Guardians. Pallante's team is 8-10-0 against the spread in his starts this season. When Pallante starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Guardians have a 3-11-0 ATS record in Williams' 14 starts that had a set spread. The Guardians are 1-3 in Williams' four starts this season that they were the underdog on the moneyline.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.5%)

Cardinals vs Guardians Moneyline

• St. Louis is the favorite, -124 on the moneyline, while Cleveland is a +106 underdog on the road.

Cardinals vs Guardians Spread

• The Cardinals are hosting the Guardians and are favored by 1.5 runs on the spread. The Cardinals are +162 to cover the runline, with the Guardians being -196.

Cardinals vs Guardians Over/Under

• Cardinals versus Guardians on Sept. 22 has an over/under of 7.5 runs, with the odds on the over -106 and the under set at -114.

Bet on St. Louis Cardinals vs. Cleveland Guardians on FanDuel today!

Cardinals vs Guardians Betting Trends

• The Cardinals have been victorious in 33, or 48.5%, of the 68 contests they have been chosen as favorites in this season.
• This year St. Louis has won 23 of 49 games when listed as at least -124 on the moneyline.
• The Cardinals' games have gone over the total in 69 of their 150 opportunities.
• The Cardinals are 72-78-0 against the spread in their 150 games that had a posted line this season.
• The Guardians have won 26 of the 57 games they were listed as the moneyline underdog this season (45.6%).
• Cleveland has a record of 13-22 when it has played as a moneyline underdog with odds of +106 or longer (37.1%).
• The Guardians have played in 154 games with an over/under set, and have combined with their opponents to go over the total 70 times (70-76-8).
• The Guardians have put together an 82-72-0 record ATS this season.

Cardinals Player Leaders

• Brendan Donovan leads St. Louis with an OBP of .339, plus a team-best slugging percentage of .409. He's batting .273 on the season.
• Among qualified batters, he is 32nd in batting average, his on-base percentage ranks 40th, and he is 80th in slugging.
• Alec Burleson leads St. Louis with 141 hits. He is batting .269 this season and has 41 extra-base hits. He's also slugging .427 with an on-base percentage of .312.
• He is 39th in batting average, 96th in on-base percentage and 66th in slugging among qualifying hitters.
• Nolan Arenado has 150 hits this season and has a slash line of .268/.323/.393.
• Arenado heads into this game with two games in a row with at least one hit. In his last five games he is batting .313 with a double, three walks and two RBI.
• Masyn Winn is batting .267 with a .313 OBP and 51 RBI for St. Louis this season.

Guardians Player Leaders

• Jose Ramirez has racked up a slugging percentage of .523 and has 166 hits, both team-best marks for the Guardians. He's batting .276 and with an on-base percentage of .333.
• Including all qualifying hitters in the big leagues, he is 29th in batting average, 49th in on-base percentage and 12th in slugging percentage.
• Josh Naylor is hitting .241 with 26 doubles, 31 home runs and 56 walks. He's slugging .459 with an on-base percentage of .318.
• His batting average is 98th among all qualified players, his on-base percentage is 86th, and he is 41st in slugging.
• Andres Gimenez is batting .257 with 22 doubles, a triple, nine home runs and 26 walks.
• Lane Thomas is hitting .241 with 26 doubles, three triples, 14 home runs and 44 walks.

Cardinals vs Guardians Head to Head

• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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